All Outputs (12)

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Soft power, cultural relations and conflict through Eurovision and other mega-events: a literature review (2024)
Report
Baker, C., Atkinson, D., Grabher, B., & Howcroft, M. (2024). Soft power, cultural relations and conflict through Eurovision and other mega-events: a literature review. British Council

First paragraph: This literature review explores the significance of the Eurovision Song Contest for soft power strategies and cultural relations activities, especially at times of conflict and international aggression.

Culture, place and partnership: the cultural relations of Eurovision 2023 (2024)
Report
Baker, C., Atkinson, D., Grabher, B., & Howcroft, M. (2024). Culture, place and partnership: the cultural relations of Eurovision 2023. British Council

Foreword: This report tells the story of the Eurovision Song Contest in 2023, when the UK found itself as host on behalf of the 2022 winners Ukraine, due to Russia’s full-scale invasion of the country in 2021. As the UK’s 2022 entry Sam Ryder put it... Read More about Culture, place and partnership: the cultural relations of Eurovision 2023.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., Jones, R. W., Collins, R., van Horik, J., Pentecost, C., Allan, L., & Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.

Conclusions (2022)
Book Chapter
Williams, T. M. (2022). Conclusions. In T. M. Williams, K. Samset, & G. Holst Volden (Eds.), The Front-end of Large Public Projects: Paradoxes and Ways Ahead (191-204). Taylor & Francis (Routledge). https://doi.org/10.4324/9781003257172-8

Projects are the key organisational form used to deliver transformational policy change and build new systems in the public sector. Traditional thinking has looked at the project as an exercise to carry out a defined task in a specific time, at a spe... Read More about Conclusions.

Project success (2022)
Book Chapter
Williams, T. M. (2022). Project success. In T. M. Williams, K. Samset, & G. Holst Volden (Eds.), The Front-end of Large Public Projects: Paradoxes and Ways Ahead (10-42). London: Taylor & Francis (Routledge). https://doi.org/10.4324/9781003257172-2

This chapter looks at the academic background to this question, dividing the idea of success into strategic and tactical success. It looks at the various paradoxes that accompany major public projects as criteria for success are developed. The combin... Read More about Project success.

Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis (2022)
Journal Article
Peters, R., Xu, Y., Fitzgerald, O., Aung, H. L., Beckett, N., Bulpitt, C., Chalmers, J., Forette, F., Gong, J., Harris, K., Humburg, P., Matthews, F. E., Staessen, J. A., Thijs, L., Tzourio, C., Warwick, J., Woodward, M., & Anderson, C. S. (2022). Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. European Heart Journal, 43(48), 4980-4990. https://doi.org/10.1093/eurheartj/ehac584

Aims Observational studies indicate U-shaped associations of blood pressure (BP) and incident dementia in older age, but randomized controlled trials of BP-lowering treatment show mixed results on this outcome in hypertensive patients. A pooled indiv... Read More about Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis.

SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit (2021)
Journal Article
Earle, F., Huddlestone, J., Williams, T., Stock-Williams, C., van der Mijle-Meijer, H., de Vries, L., …Moore, G. (in press). SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit. Wind energy, https://doi.org/10.1002/we.2647

This paper describes the SPOWTT project. The intention of this project was to understand how sailing by crew transfer vessel (CTVs) to offshore wind farms affects the mental and physical wellbeing of individuals on board. The focus was on quantifying... Read More about SPOWTT: Improving the Safety and Productivity of Offshore Wind Technician Transit.

The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success (2021)
Journal Article
Ojiako, U., Petro, Y., Marshall, A., & Williams, T. (in press). The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success. Production planning & control, https://doi.org/10.1080/09537287.2021.1909168

Some studies suggest that organizational ambidexterity is best orchestrated through individual projects. However, stand-alone individual projects are relatively limited in scope, while suffering from susceptibilities to horizontal and vertical segmen... Read More about The impact of project portfolio management practices on the relationship between organizational ambidexterity and project performance success.