All Outputs (68)

Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project (2019)
Journal Article
Shafto, M. A., Henson, R. N., Matthews, F. E., Taylor, J. R., Emery, T., Erzinclioglu, S., Hanley, C., Rowe, J. B., Cusack, R., Calder, A. J., Marslen-Wilson, W. D., Duncan, J., Dalgleish, T., Brayne, C., Cam-CAN, & Tyler, L. K. (2020). Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project. Journal of Aging and Health, 32(9), 1029-1041. https://doi.org/10.1177/0898264319878095

Objective: Studies of “healthy” cognitive aging often focus on a limited set of measures that decline with age. The current study argues that defining and supporting healthy cognition requires understanding diverse cognitive performance across the li... Read More about Cognitive Diversity in a Healthy Aging Cohort: Cross-Domain Cognition in the Cam-CAN Project.

Changing prevalence and treatment of depression among older people over two decades (2019)
Journal Article
Arthur, A., Savva, G. M., Barnes, L. E., Borjian-Boroojeny, A., Dening, T., Jagger, C., Matthews, F. E., Robinson, L., Brayne, C., The Cognitive Function, Green, E., Gao, L., Barnes, R., Baldwin, C., Comas-Herrera, A., Forster, G., Harrison, S., Ince, P. G., McKeith, I. G., Parry, B., …Woods, B. (2020). Changing prevalence and treatment of depression among older people over two decades. British Journal of Psychiatry, 216(1), 49-54. https://doi.org/10.1192/bjp.2019.193

Background Depression is a leading cause of disability, with older people particularly susceptible to poor outcomes.Aims To investigate whether the prevalence of depression and antidepressant use have changed across two decades in older people.Method... Read More about Changing prevalence and treatment of depression among older people over two decades.

Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme (2019)
Journal Article
Wu, Y. T., Clare, L., & Matthews, F. E. (2021). Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme. Aging and Mental Health, 25(1), 38-45. https://doi.org/10.1080/13607863.2019.1671316

Objectives: Depression is a common condition in dementia and has a substantial impact on quality of life and wellbeing. There is limited evidence on how depressive symptoms in the person with dementia impact on the carer, and vice versa. The aim of t... Read More about Relationship between depressive symptoms and capability to live well in people with mild to moderate dementia and their carers: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) programme.

Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts (2019)
Journal Article
Hokkanen, S. R., Kero, M., Kaivola, K., Hunter, S., Keage, H. A., Kiviharju, A., Raunio, A., Tienari, P. J., Paetau, A., Matthews, F. E., Fleming, J., Graff, C., Polvikoski, T. M., Myllykangas, L., & Brayne, C. (2020). Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain Pathology, 30(2), 364-372. https://doi.org/10.1111/bpa.12773

Limbic-predominant age-related TAR-DNA-binding protein-43 (TDP-43) encephalopathy with hippocampal sclerosis pathology (LATE-NC + HS) is a neurodegenerative disorder characterized by severe hippocampal CA1 neuron loss and TDP-43-pathology, leading to... Read More about Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts.

Living alone and cognitive function in later life (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019). Living alone and cognitive function in later life. Archives of Gerontology and Geriatrics, 81, 222-233. https://doi.org/10.1016/j.archger.2018.12.014

Background: Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later l... Read More about Living alone and cognitive function in later life.

Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification (2014)
Journal Article
van den Hout, A., Ogurtsova, E., Gampe, J., & Matthews, F. E. (2014). Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification. Demographic Research, 30(1), 1219-1244. https://doi.org/10.4054/DemRes.2014.30.42

Background: A continuous-time three-state model can be used to describe change in cognitive function in the older population. State 1 corresponds to normal cognitive function, state 2 to cognitive impairment, and state 3 to dead. For statistical infe... Read More about Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification.

Biomarkers, dementia, and public health (2009)
Presentation / Conference Contribution
Wright, C. F., Hall, A., Matthews, F. E., & Brayne, C. Biomarkers, dementia, and public health

Public health is defined as the organized efforts of society to improve health. This is often framed in terms of prevention, with primary, secondary, and tertiary prevention representing, respectively, fundamental prevention through understanding of... Read More about Biomarkers, dementia, and public health.

Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression (2005)
Presentation / Conference Contribution
Brayne, C., Gao, L., & Matthews, F. Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression

There are many challenges facing epidemiologists wishing to investigate relationships between physical activity, obesity, diabetes, dementia and depression, all of which are complex fields in their own right. There is a large literature investigating... Read More about Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression.