All Outputs (9)

Sporopollenin : applications in water purification (2021)
Thesis
Meichanetzoglou, A. Sporopollenin : applications in water purification. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223849

Water pollution from emerging contaminants is increasingly in the spotlight, as research on the impacts on the environment is revealing more about the dangers to both animals in the aquatic environment and human health. Pharmaceuticals, personal care... Read More about Sporopollenin : applications in water purification.

The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance (2020)
Journal Article
Satta, G., Witney, A. A., Begum, N., Ortiz Canseco, J., Boa, A. N., & McHugh, T. D. (2020). The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance. Antimicrobial agents and chemotherapy, 64(9), Article e00675-20. https://doi.org/10.1128/AAC.00675-20

Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action an... Read More about The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance.

Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells (2019)
Thesis
Adeniran, O. I. Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4222358

Most standard anticancer drugs are non-selective in their cytotoxicity towards cancerous versus normal cells. Therefore, there is a need for the development of selective and targeted anticancer agents. Previous studies have reported upregulation of t... Read More about Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells.

Chemically modified sporopollenin as a solid support for heterogeneous catalysts (2019)
Thesis
Abimbade, S. F. Chemically modified sporopollenin as a solid support for heterogeneous catalysts. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4222418

Application of the principles of ‘Green Chemistry’ has been a focus in recent years in the synthesis of fine chemicals, and solid-phase catalysts are useful tools in that endeavour compared to stoichiometric reagents. Another important principle of ‘... Read More about Chemically modified sporopollenin as a solid support for heterogeneous catalysts.

The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification (2016)
Thesis
Knaggs, J. D. The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4219218

Transient Receptor Potential A1 (TRPA1) is commonly known as the detector of a broad range of noxious chemical agents both exogenous and endogenous. TRPA1 detects these chemicals through a reversible covalent modification mechanism that allows most e... Read More about The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification.

Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone (2015)
Thesis
Lovell, C. J. Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223288

The subject of this thesis is the synthesis and impurity profiling of semi-synthetic opiates, namely buprenorphine and naloxone. Opiates are a class of naturally occurring narcotic analgesic drugs produced from the opium poppy Papaver somniferum, in... Read More about Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone.

Novel applications of surface-modified sporopollenin exine capsules (2013)
Thesis
Huang, Y. Novel applications of surface-modified sporopollenin exine capsules. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4215614

The external shell (exine) of plant spores and pollen grains is composed of sporopollenin, which is an organic polymer renowned for its exceptional resistance to physical and chemical attack. The resilience of sporopollenin to high temperature, press... Read More about Novel applications of surface-modified sporopollenin exine capsules.

Analogues of bredinin: Synthesis of 5-hydroxyimidazoles from acyclic precursors (2008)
Thesis
Middleton, D. F. Analogues of bredinin: Synthesis of 5-hydroxyimidazoles from acyclic precursors. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4208664

Compared to 1-substituted-5-aminoimidazoles relatively few 1-substituted-5-hydroxyimidazoles have been reported; however, an interesting 1-substituted-5-hydroxyimidazole is the immunosuppressive agent bredinin, which shows antiviral, antimalarial, an... Read More about Analogues of bredinin: Synthesis of 5-hydroxyimidazoles from acyclic precursors.

Synthesis of porphyrins and metalloporphyrins for biological applications (2005)
Thesis
Ita, S. Synthesis of porphyrins and metalloporphyrins for biological applications. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221109

Porphyrins are ideal candidates for PDT (Photodynamic therapy). Their ability to localise preferentially in diseased tissue allows specific targeting of cancerous tissue in certain areas. In recent years, linking photosensitisers to sugar moieties ha... Read More about Synthesis of porphyrins and metalloporphyrins for biological applications.