All Outputs (3)

Store-operated calcium channels regulated by hyperosmolarity as a mechanism underlying endothelial dysfunction in the hypersomolar condition (2020)
Thesis
Hallett, T. G. Store-operated calcium channels regulated by hyperosmolarity as a mechanism underlying endothelial dysfunction in the hypersomolar condition. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4222678

Introduction
Hyperosmolarity is a concomitant factor to the hyperglycaemia observed in diabetes mellitus, a disease known to affect the function of endothelial cells and cause vascular damage. Previous studies have found that hyperglycaemia is capab... Read More about Store-operated calcium channels regulated by hyperosmolarity as a mechanism underlying endothelial dysfunction in the hypersomolar condition.

Regulation of store-operated channel molecules ORAI and STIM by oxidative stress in blood vessels (2013)
Thesis
Daskoulidou, N. Regulation of store-operated channel molecules ORAI and STIM by oxidative stress in blood vessels. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4221321

ORAI and STIM genes are recently identified store-operated calcium channel molecules that play important roles in human physiology. In this thesis, the effects of oxidative stress conditions including high glucose, homocysteine and H₂O₂ on the expres... Read More about Regulation of store-operated channel molecules ORAI and STIM by oxidative stress in blood vessels.

Pharmacological regulation and function of store-operated calcium channels (2012)
Thesis
Zeng, B. Pharmacological regulation and function of store-operated calcium channels. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4213635

Store-operated Ca²⁺ entry (SOCE) is an important Ca²⁺ influx pathway existing in almost all types of mammalian cell. STIM1, ORAI and TRPC have been regarded as the molecular basis of SOCE. Once the endoplasmic reticulum (ER) Ca²⁺ store is depleted, S... Read More about Pharmacological regulation and function of store-operated calcium channels.