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Comparing functional decline and distress from symptoms in people with thoracic life-limiting illnesses: Lung cancers and non-malignant end-stage respiratory diseases (2021)
Journal Article
Barnes-Harris, M., Allingham, S., Morgan, D., Ferreira, D., Johnson, M. J., Eagar, K., & Currow, D. (2021). Comparing functional decline and distress from symptoms in people with thoracic life-limiting illnesses: Lung cancers and non-malignant end-stage respiratory diseases. Thorax, 76(10), 989-995. https://doi.org/10.1136/thoraxjnl-2020-216039

© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. Background: Malignant and non-malignant respiratory diseases account for >4.6 million deaths annually worldwide. Despite similar symptom burd... Read More about Comparing functional decline and distress from symptoms in people with thoracic life-limiting illnesses: Lung cancers and non-malignant end-stage respiratory diseases.

Barriers and enablers of implementation of alcohol guidelines with pregnant women: a cross-sectional survey among UK midwives (2021)
Journal Article
Smith, L. A., Dyson, J., Watson, J., & Schölin, L. (2021). Barriers and enablers of implementation of alcohol guidelines with pregnant women: a cross-sectional survey among UK midwives. BMC Pregnancy and Childbirth, 21(1), Article 134. https://doi.org/10.1186/s12884-021-03583-1

© 2021, The Author(s). Background: In 2016, the UK Chief Medical Officers revised their guidance on alcohol and advised women to abstain from alcohol if pregnant or planning pregnancy. Midwives have a key role in advising women about alcohol during p... Read More about Barriers and enablers of implementation of alcohol guidelines with pregnant women: a cross-sectional survey among UK midwives.

Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It? (2021)
Journal Article
Sykes, D. L., Holdsworth, L., Jawad, N., Gunasekera, P., Morice, A. H., & Crooks, M. G. (2021). Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?. Lung, 199(2), 113-119. https://doi.org/10.1007/s00408-021-00423-z

© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature. The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the l... Read More about Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?.

Socioeconomic position and use of hospital-based care towards the end of life: a mediation analysis using the English Longitudinal Study of Ageing (2021)
Journal Article
Davies, J. M., Maddocks, M., Chua, K. C., Demakakos, P., Sleeman, K. E., & Murtagh, F. E. (2021). Socioeconomic position and use of hospital-based care towards the end of life: a mediation analysis using the English Longitudinal Study of Ageing. The Lancet. Public Health, 6(3), e155-e163. https://doi.org/10.1016/S2468-2667%2820%2930292-9

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Many patients prefer to avoid hospital-based care towards the end of life, yet hospitalisation is common and more likely for peopl... Read More about Socioeconomic position and use of hospital-based care towards the end of life: a mediation analysis using the English Longitudinal Study of Ageing.

Hierarchical Multiscale Recurrent Neural Networks for Detecting Suicide Notes (2021)
Journal Article
Schoene, A. M., Turner, A. P., De Mel, G., & Dethlefs, N. (in press). Hierarchical Multiscale Recurrent Neural Networks for Detecting Suicide Notes. IEEE Transactions on Affective Computing, https://doi.org/10.1109/TAFFC.2021.3057105

Recent statistics in suicide prevention show that people are increasingly posting their last words online and with the unprecedented availability of textual data from social media platforms researchers have the opportunity to analyse such data. Furth... Read More about Hierarchical Multiscale Recurrent Neural Networks for Detecting Suicide Notes.

The challenges of caring for people dying from COVID-19: a multinational, observational study (CovPall) (2021)
Journal Article
Oluyase, A. O., Hocaoglu, M., Cripps, R. L., Maddocks, M., Walshe, C., Fraser, L. K., Preston, N., Dunleavy, L., Bradshaw, A., Murtagh, F. E., Bajwah, S., Sleeman, K. E., & Higginson, I. J. (in press). The challenges of caring for people dying from COVID-19: a multinational, observational study (CovPall). Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2021.01.138

Context: Systematic data on the care of people dying with COVID-19 are scarce. Objectives: To understand the response of and challenges faced by palliative care services during the COVID-19 pandemic, and identify associated factors. Methods: We surve... Read More about The challenges of caring for people dying from COVID-19: a multinational, observational study (CovPall).

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals (2021)
Journal Article
Hosseini, S. A., Zahedipour, F., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (in press). Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. BioFactors, https://doi.org/10.1002/biof.1713

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokin... Read More about Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals.

The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres (2021)
Journal Article
Burton, W., Sahota, P., Twiddy, M., Brown, J., & Bryant, M. (in press). The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres. Prevention Science, https://doi.org/10.1007/s11121-021-01205-y

Background
Poor participant engagement threatens the potential impact and cost effectiveness of public health programmes preventing meaningful evaluation and wider application. Although barriers and levers to engagement with public health programmes... Read More about The development of a multilevel intervention to optimise participant engagement with an obesity prevention programme delivered in UK children’s centres.

A double-blind randomized controlled trial for the effects of dry needling on upper limb dysfunction in patients with stroke (2021)
Journal Article
Tavakol, Z., Shariat, A., Ansari, N., Ghannadi, S., Honarpishe, R., Dommerholt, J., Noormohammadpour, P., & Ingle, L. (2021). A double-blind randomized controlled trial for the effects of dry needling on upper limb dysfunction in patients with stroke. Acupuncture and Electro-Therapeutics Research, 45(2-4), 115-124. https://doi.org/10.3727/036012921X16112663844923

Spasticity is one of the main complications of a stroke. This double-blind, randomized controlled trial aimed to compare the result of three sessions of dry needling (DN) versus sham DN on the affected upper limbs in post-stroke survivors. We recruit... Read More about A double-blind randomized controlled trial for the effects of dry needling on upper limb dysfunction in patients with stroke.

Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation (2021)
Journal Article
Bolanle, I. O., Riches-Suman, K., Loubani, M., Williamson, R., & Palmer, T. M. (2021). Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation. Nutrition, metabolism, and cardiovascular diseases : NMCD, https://doi.org/10.1016/j.numecd.2021.01.017

Background and Aim:
Coronary artery bypass graft (CABG) using autologous saphenous vein continues to be a gold standard procedure to restore the supply of oxygen-rich blood to the heart muscles in coronary artery disease (CAD) patients with or with... Read More about Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation.

Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models (2021)
Journal Article
Mohammadi, S., Abdollahi, E., Nezamnia, M., Esmaeili, S. A., Tavasolian, F., Sathyapalan, T., & Sahebkar, A. (2021). Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models. International immunopharmacology, 90, Article 107195. https://doi.org/10.1016/j.intimp.2020.107195

Since half of the genes are inherited from the paternal side, the maternal immune system has to tolerate the presence of foreign paternal antigens. Regulatory T cells facilitate the development and maintenance of peripheral tissue tolerance of the fe... Read More about Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models.

Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study (2021)
Journal Article
Genberg, J., Davies, J. M., Ahmadi, Z., Currow, D., Johnson, M. J., Tanash, H., Bajwah, S., & Ekström, M. (2021). Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study. ERJ Open Research, 7(1), 1-7. https://doi.org/10.1183/23120541.00716-2020

Background: Despite evidence that opioids might relieve chronic breathlessness, physicians may still be reluctant to prescribe them due to safety concerns. By contrast, benzodiazepine (BDZ) prescribing often seeks to reduce chronic breathlessness des... Read More about Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study.

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia (2021)
Journal Article
Lin, W. Y., Fordham, S. E., Sunter, N., Elstob, C., Rahman, T., Willmore, E., Shepherd, C., Strathdee, G., Mainou-Fowler, T., Piddock, R., Mearns, H., Barrow, T., Houlston, R. S., Marr, H., Wallis, J., Summerfield, G., Marshall, S., Pettitt, A., Pepper, C., Fegan, C., …Allan, J. M. (2021). Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia. Nature communications, 12(1), Article 665. https://doi.org/10.1038/s41467-020-20822-9

© 2021, The Author(s). Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognost... Read More about Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study (2021)
Journal Article
Clark, J., Amoakwa, E., Wright-Hughes, A., Blenkinsopp, J., Currow, D. C., Meads, D., Farrin, A., Allgar, V., Macleod, U., & Johnson, M. (2021). A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study. PLoS ONE, 16(1), Article e0245647. https://doi.org/10.1371/journal.pone.0245647

Background People with cancer often have unidentified symptoms and social care needs. The Needs Assessment Tool-Cancer (NAT-C) is a validated, structured method of assessing patient/ carer concerns and prompting action, to address unmet need. Aims As... Read More about A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC) (2021)
Journal Article
Mariwah, S., Machistey Abane, A., Asiedu Owusu, S., Kasim, A., Robson, E., Castelli, M., & Hampshire, K. (in press). Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC). Global Public Health, 1-14. https://doi.org/10.1080/17441692.2021.1874467

While mobile phones promise to be an important tool for bridging the healthcare gaps in resource-poor areas in developing countries, scalability and sustainability of mobile phones for health (mhealth) interventions still remain a major challenge. Me... Read More about Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC).

Brief interventions to prevent excessive alcohol use in adolescents at low-risk presenting to Emergency Departments: Three-arm, randomised trial of effectiveness and cost-effectiveness (2021)
Journal Article
Deluca, P., Coulton, S., Alam, M. F., Boniface, S., Cohen, D., Donoghue, K., Gilvarry, E., Kaner, E., Maconochie, I., McArdle, P., McGovern, R., Newbury-Birch, D., Patton, R., Pellatt-Higgins, T., Phillips, C., Phillips, T., Pockett, R. D., Russell, I., Strang, J., & Drummond, C. (in press). Brief interventions to prevent excessive alcohol use in adolescents at low-risk presenting to Emergency Departments: Three-arm, randomised trial of effectiveness and cost-effectiveness. International Journal of Drug Policy, Article 103113. https://doi.org/10.1016/j.drugpo.2021.103113

© 2021 Background: Alcohol consumption and related harm increase rapidly from the age of 12 years. We evaluated whether alcohol screening and brief intervention is effective and cost-effective in delaying hazardous or harmful drinking amongst low-ris... Read More about Brief interventions to prevent excessive alcohol use in adolescents at low-risk presenting to Emergency Departments: Three-arm, randomised trial of effectiveness and cost-effectiveness.

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (2021)
Journal Article
Brown, J. M., Croft, J., Poad, H., Bell, R., Collinson, M., Gordon, K., Dooldeniya, M., Conroy, S., Catto, J. W., Noon, A. P., Simms, M., Chahal, R., Jain, S., Koenig, P., Johnson, M., Twiddy, M., & Goodwin, L. (2021). Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study. Journal of Clinical Oncology, 39(3), 202-214. https://doi.org/10.1200/JCO.20.01665

PURPOSE: High-grade nonmuscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease. Treatments include intravesical maintenance Bacillus Calmette-Guerin (mBCG) and radical cystectomy (RC). We wanted to understand whether a randomized trial co... Read More about Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study.