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Exploring hypoxic biology to improve radiotherapy outcomes (2022)
Journal Article
Li, C., Wiseman, L., Okoh, E., Lind, M., Roy, R., Beavis, A., & Monteiro dos Santos Pires, I. (2022). Exploring hypoxic biology to improve radiotherapy outcomes. Expert Reviews in Molecular Medicine, 24, Article E21. https://doi.org/10.1017/erm.2022.14

Ionising radiotherapy is a well-established, effective cancer treatment modality, whose efficacy has improved with the application of newer technological modalities. However, patient outcomes are governed and potentially limited by aspects of tumour... Read More about Exploring hypoxic biology to improve radiotherapy outcomes.

Visualizing community networks to recruit South Asian participants for interviews about bowel cancer screening (2022)
Journal Article
Howcutt, S. J., Saini, P., Henshall, C., Brett, J., Watson, E., & Smith, L. A. (2022). Visualizing community networks to recruit South Asian participants for interviews about bowel cancer screening. Journal of Cancer Policy, 32, Article 100333. https://doi.org/10.1016/j.jcpo.2022.100333

Background: South Asians make up the largest ethnic minority group in England and Wales. Yet this group is underrepresented in some programmes to promote health, such as cancer screening. A challenge to addressing such health disparities is the diffi... Read More about Visualizing community networks to recruit South Asian participants for interviews about bowel cancer screening.

Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial (2022)
Journal Article
Souroullas, P., Barnes, R., Carradice, D., Smith, G., Huang, C., & Chetter, I. (2022). Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial. British journal of surgery, 109(5), 426-432. https://doi.org/10.1093/bjs/znac053

BACKGROUND: Lower limb amputation (LLA) is typically described as 'clean surgery', but surgical-site infection (SSI) rates are high and there is significant variation in antibiotic prophylaxis practice. This study aimed to determine whether an extend... Read More about Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial.

Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (in press). Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Archives of Gynecology and Obstetrics, https://doi.org/10.1007/s00404-022-06549-6

Context: Polycystic ovary syndrome (PCOS) is a complex endocrine disease that affects women of reproductive age and is characterised by biochemical and clinical androgen excess. Aim: To evaluate the efficacy of pharmacological interventions used to d... Read More about Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response (2022)
Journal Article
Nandakumar, M., Moin, A. S. M., Ramanjaneya, M., Qaissi, A. A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response. Diabetes, Obesity and Metabolism, 24(8), 1483-1497. https://doi.org/10.1111/dom.14716

Introduction: There is evidence that fibroblast growth factor (FGF) levels may be implicated in hypoglycaemia, with FGF19 being a potential contributor to insulin-independent pathways driving postprandial hypoglycaemia following bariatric surgery and... Read More about Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response.

Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups (2022)
Journal Article
Yale, J. F., Bodholdt, U., Catarig, A. M., Catrina, S., Clark, A., Ekberg, N. R., Erhan, U., Holmes, P., Knudsen, S. T., Liutkus, J., Sathyapalan, T., Schultes, B., & Rudofsky, G. (2022). Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups. BMJ Open Diabetes Research and Care, 10(2), Article e002619. https://doi.org/10.1136/bmjdrc-2021-002619

INTRODUCTION: This post hoc pooled analysis of four real-world studies (SURE Canada, Denmark/Sweden, Switzerland and UK) aimed to characterize the use of once-weekly (OW) semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in patients... Read More about Real-world use of once-weekly semaglutide in patients with type 2 diabetes: pooled analysis of data from four SURE studies by baseline characteristic subgroups.

Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy (2022)
Journal Article
Bibak, B., Shakeri, F., Keshavarzi, Z., Mollazadeh, H., Javid, H., Jalili-Nik, M., Sathyapalan, T., Afshari, A. R., & Sahebkar, A. (2022). Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy. Current medicinal chemistry, 29(26), 4507-4528. https://doi.org/10.2174/0929867329666220224112811

The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by re... Read More about Anticancer Mechanisms of Berberine: A Good Choice for Glioblasto-ma Multiforme Therapy.

Predictors of health facility childbirth among unmarried and married youth in Uganda (2022)
Journal Article
Agaba, P., Magadi, M., & Orton, B. (2022). Predictors of health facility childbirth among unmarried and married youth in Uganda. PLoS ONE, 17(4), Article e0266657. https://doi.org/10.1371/journal.pone.0266657

Background Uganda has a high maternal mortality rate combined with poor use of health facilities at childbirth among youth. Improved use of maternal health services by the youth would help reduce maternal deaths in the country. Predictors of use of h... Read More about Predictors of health facility childbirth among unmarried and married youth in Uganda.

Digital Promotion of Suicide: A Platform-Level Ethical Analysis (2022)
Journal Article
Cohen-Almagor, R., & Lehman-Wilzig, S. (2022). Digital Promotion of Suicide: A Platform-Level Ethical Analysis. Journal of Media Ethics, https://doi.org/10.1080/23736992.2022.2057994

This article utilizes Aristotelian and Kantian philosophies to probe the social responsibilities of internet intermediaries that in one way or another assist and promote suicide. Striking a balance between freedom of expression and social responsibil... Read More about Digital Promotion of Suicide: A Platform-Level Ethical Analysis.

FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis (2022)
Journal Article
Blissett, R., Blissett, D., Levrat-Guillen, F., Deshmukh, H., Wilmot, E. G., Ryder, R. E., Walton, C., & Sathyapalan, T. (2022). FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis. BMJ Open Diabetes Research and Care, 10(2), Article e002580. https://doi.org/10.1136/bmjdrc-2021-002580

INTRODUCTION: This study aims to estimate the budget impact of increased uptake of the FreeStyle Libre Flash Glucose Monitoring system in people with type 1 diabetes mellitus (T1DM) in the UK. RESEARCH DESIGN AND METHODS: A budget impact model was de... Read More about FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis.

Erratum: Correction to: Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists? (Alcohol and alcoholism (Oxford, Oxfordshire) (2022) 57 5 (602-608)) (2022)
Journal Article
Dhital, R., Coleman, R., Day, E., Drummond, C., Lingford-Hughes, A., Marsden, J., Phillips, T., Sinclair, J., Strang, J., Weinman, J., Whittlesea, C., Widyaratna, K., & Donoghue, K. (2022). Erratum: Correction to: Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists? (Alcohol and alcoholism (Oxford, Oxfordshire) (2022) 57 5 (602-608)). Alcohol and Alcoholism, 57(5), 642. https://doi.org/10.1093/alcalc/agac016

Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System (2022)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2022). Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System. ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.2c00168

Tumor cell spheroids and 3D cell culture have generated a lot of interest in the past decade due to their relative ease of production and biomedical research applications. To date, the frontier in tumor 3D models has been pushed to the level of perso... Read More about Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System.

Anatomy of the pancreas and spleen (2022)
Journal Article
Bazira, P. J., & Mahadevan, V. (2022). Anatomy of the pancreas and spleen. Surgery (Oxford), 40(4), 213-218. https://doi.org/10.1016/j.mpsur.2022.02.002

The pancreas is a large, retroperitoneal organ situated immediately behind the posterior wall of the lesser sac, in the floor of the supracolic compartment of the abdominal cavity. Although principally an exocrine gland, the pancreas also performs cr... Read More about Anatomy of the pancreas and spleen.

Effectiveness and cost-effectiveness of face-to-face and electronic brief interventions versus screening alone to reduce alcohol consumption among high-risk adolescents presenting to emergency departments: three-arm pragmatic randomized trial (SIPS Junior high risk trial) (2022)
Journal Article
Deluca, P., Coulton, S., Alam, M. F., Boniface, S., Donoghue, K., Gilvarry, E., Kaner, E., Lynch, E., Maconochie, I., McArdle, P., McGovern, R., Newbury‐Birch, D., Patton, R., Pellat‐Higgins, T., Phillips, C., Phillips, T., Pockett, R. D., Russell, I. T., Strang, J., & Drummond, C. (2022). Effectiveness and cost-effectiveness of face-to-face and electronic brief interventions versus screening alone to reduce alcohol consumption among high-risk adolescents presenting to emergency departments: three-arm pragmatic randomized trial (SIPS Junior high risk trial). Addiction, https://doi.org/10.1111/add.15884

Background and aims: Alcohol use increases throughout adolescence. Emergency department (ED) attendance is an opportunity for alcohol screening and brief intervention (ASBI), which is effective for adults. This trial evaluated the effectiveness and c... Read More about Effectiveness and cost-effectiveness of face-to-face and electronic brief interventions versus screening alone to reduce alcohol consumption among high-risk adolescents presenting to emergency departments: three-arm pragmatic randomized trial (SIPS Junior high risk trial).

Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions (2022)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2022). Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions. Bioengineering, 9(3), Article 126. https://doi.org/10.3390/bioengineering9030126

Three‐dimensional cell culture has been extensively involved in biomedical applications due to its high availability and relatively mature biochemical properties. However, single 3D cell culture models based on hydrogel or various scaffolds do not me... Read More about Vascularized Co‐Culture Clusteroids of Primary Endothelial and Hep‐G2 Cells Based on Aqueous Two‐Phase Pickering Emulsions.

A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results (2022)
Journal Article
Bamidele, O. O., Green, T., Tookey, S., Walabyeki, J., & Macleod, U. (2022). A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results. European Journal of Cancer Care, https://doi.org/10.1111/ecc.13574

Objective: This study explored women's perspectives on the acceptability of including new cancer information with an all-clear breast or cervical screening result letter (using ovarian cancer as a case study). Methods: In 2016, six focus group discus... Read More about A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results.

Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists? (2022)
Journal Article
Dhital, R., Coleman, R., Day, E., Drummond, C., Lingford-Hughes, A., Marsden, J., Phillips, T., Sinclair, J., Strang, J., Weinman, J., Whittlesea, C., Widyaratna, K., & Donoghue, K. (2022). Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists?. Alcohol and Alcoholism, 57(5), 602-608. https://doi.org/10.1093/alcalc/agac011

Aims: To understand service users' views and experiences of alcohol relapse prevention medication, views of a telephone behavioural modification intervention delivered by pharmacists and the use of Contingency Management (CM) to support acamprosate a... Read More about Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists?.

Environmental Sustainability in Respiratory Care: An Overview of the healthCARe-Based envirONmental Cost of Treatment (CARBON) Programme (2022)
Journal Article
Wilkinson, A., Maslova, E., Janson, C., Xu, Y., Haughney, J., Quint, J. K., Budgen, N., Menzies-Gow, A., Bell, J., & Crooks, M. G. (2022). Environmental Sustainability in Respiratory Care: An Overview of the healthCARe-Based envirONmental Cost of Treatment (CARBON) Programme. Advances in Therapy, 39, 2270–2280. https://doi.org/10.1007/s12325-022-02076-7

Introduction: Faced with the challenges of climate change, countries are seeking to decarbonise their economies. A greater understanding of what comprises the carbon footprint of care in healthcare systems will identify potential strategies for reduc... Read More about Environmental Sustainability in Respiratory Care: An Overview of the healthCARe-Based envirONmental Cost of Treatment (CARBON) Programme.