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Subcutaneous furosemide in advanced heart failure: service improvement project (2021)
Journal Article
Birch, F., Boam, E., Parsons, S., Ghosh, J., & Johnson, M. J. (in press). Subcutaneous furosemide in advanced heart failure: service improvement project. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2020-002803

Objectives: In severe heart disease, parenteral administration of loop diuretic is often needed. We present clinical outcomes from episodes of care using subcutaneous continuous infusion of furosemide (CSCI-furosemide).

Methods: Retrospective revi... Read More about Subcutaneous furosemide in advanced heart failure: service improvement project.

Improving the Reporting of Primary Care Research: An International Survey of Researchers (2021)
Journal Article
Phillips, W. R., Sturgiss, E., Hunik, L., Glasziou, P. P., olde Hartman, T., Orkin, A., Reeve, J., Russell, G. M., & van Weel, C. (2021). Improving the Reporting of Primary Care Research: An International Survey of Researchers. Journal of the American Board of Family Medicine, 34(1), 12-21. https://doi.org/10.3122/jabfm.2021.01.200266

PURPOSE: To assess opportunities to improve reporting of primary care (PC) research to better meet the needs of its varied users. METHODS: International, interprofessional online survey of PC researchers and users, 2018 to 2019. Respondents used Like... Read More about Improving the Reporting of Primary Care Research: An International Survey of Researchers.

Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK (2021)
Journal Article
Schölin, L., Mukherjee, R. A., Aiton, N., Blackburn, C., Brown, S., Flemming, K. M., …Cook, P. A. (2021). Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK. Archives of Disease in Childhood, 106(7), 636-640. https://doi.org/10.1136/archdischild-2020-320435

Estimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD) - the most common neurodevelopmental condition - are high. Considering the significant health and social impacts of FASD,... Read More about Fetal alcohol spectrum disorders: An overview of current evidence and activities in the UK.

Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme (2021)
Journal Article
Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., Javid, H., Mollazadeh, H., Sathyapalan, T., & Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805

The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and... Read More about Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme.

Bayesian Value-at-Risk backtesting: The case of annuity pricing (2021)
Journal Article
Leung, M., Li, Y., Pantelous, A. A., & Vigne, S. A. (in press). Bayesian Value-at-Risk backtesting: The case of annuity pricing. European journal of operational research, https://doi.org/10.1016/j.ejor.2020.12.051

We propose new Unconditional, Independence and Conditional Coverage VaR-forecast backtests for the case of annuity pricing under a Bayesian framework that significantly minimise the direct and indirect effects of p-hacking or other biased outcomes in... Read More about Bayesian Value-at-Risk backtesting: The case of annuity pricing.

The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase (2021)
Journal Article
Merkel, K., Loska, B., Welch, C., Mehl, G. H., & Kocot, A. (2021). The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase. RSC advances, 11(5), 2917-2925. https://doi.org/10.1039/d0ra10481g

The understanding of the relationship between molecular structure and the formation of the nematic twist-bend phase is still at an early stage of development. This is mainly related to molecular geometry, while the correlation between the nematic twi... Read More about The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase.

Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA (2021)
Journal Article
Knight, C., Baskaran, M., Bunting, M. J., Champagne, M., Potts, M., Wahl, D., Wanket, J., & Battles, J. (2021). Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA. Holocene, 31(5), 814-829. https://doi.org/10.1177/0959683620988038

Quantitative reconstructions of vegetation abundance from sediment-derived pollen systems provide unique insights into past ecological conditions. Recently, the use of pollen accumulation rates (PAR, grains cm−2 year−1) has shown promise as a bioprox... Read More about Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA.

A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+ (2021)
Journal Article
Kowser, Z., Rayhan, U., Akther, T., Redshaw, C., & Yamato, T. (2021). A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+. Materials Chemistry Frontiers, 5(5), 2173-2200. https://doi.org/10.1039/d0qm01008a

© 2021 the Partner Organisations. The development of colorimetric and fluorometric chemosensors that capable of detecting Cu2+ ions by a change in colour and fluorescence intensity has been described. Herein, chemosensors having pyrene functional gro... Read More about A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial (2021)
Journal Article
Evans, H. E., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., Chambers, S., Vincent, A. D., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(1), Article 21. https://doi.org/10.1186/s40814-020-00763-2

Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain th... Read More about Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial.

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial (2021)
Journal Article
Evans, H. E., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., Chambers, S., Vincent, A. D., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(1), Article 21. https://doi.org/10.1186/s40814-020-00763-2

Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain th... Read More about Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function (2021)
Journal Article
Huang, J., Peng, J., Pearson, J. A., Efthimiou, G., Hu, Y., Tai, N., Xing, Y., Zhang, L., Gu, J., Jiang, J., Zhao, H., Zhou, Z., Wong, F. S., & Wen, L. (2021). Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology, 18(2), 328-338. https://doi.org/10.1038/s41423-020-00590-8

Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and ho... Read More about Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Moral injury in healthcare professionals: A scoping review and discussion (2021)
Journal Article
Čartolovni, A., Stolt, M., Scott, P. A., & Suhonen, R. (in press). Moral injury in healthcare professionals: A scoping review and discussion. Nursing Ethics, https://doi.org/10.1177/0969733020966776

Moral injury emerged in the healthcare discussion quite recently because of the difficulties and challenges healthcare workers and healthcare systems face in the context of the COVID-19 pandemic. Moral injury involves a deep emotional wound and is un... Read More about Moral injury in healthcare professionals: A scoping review and discussion.

Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II (2021)
Journal Article
Bennett, H. Q., Kingston, A., Spiers, G., Robinson, L., Corner, L., Bambra, C., …Jagger, C. (2021). Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II. International Journal of Epidemiology, 50(3), 841-851. https://doi.org/10.1093/ije/dyaa271

Background: Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years... Read More about Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II.

A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry (2021)
Journal Article
Mayne, L. (2021). A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry. Journal of British cinema and television, 18(1), 34-49. https://doi.org/10.3366/jbctv.2021.0554

Despite being one of the most significant players in the British film industry of the 1960s and 1970s, Nat Cohen remains a curiously neglected figure in histories of that era. At Anglo-Amalgamated he oversaw a varied slate of productions, from B-movi... Read More about A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry.

Online child sexual exploitation: a new MIS challenge (2021)
Journal Article
Demetis, D. S., & Kietzmann, J. (2021). Online child sexual exploitation: a new MIS challenge. Journal of the Association for Information Systems, 22(1), 5-40. https://doi.org/10.17705/1jais.00652

© 2021, Association for Information Systems. All rights reserved. This paper deals with the difficult yet increasingly important MIS phenomenon of online child sexual exploitation (online CSE). Through the use of secondary and publicly available data... Read More about Online child sexual exploitation: a new MIS challenge.

Dopamine induces functional extracellular traps in microglia (2021)
Journal Article
Agrawal, I., Sharma, N., Saxena, S., Arvind, S., Chakraborty, D., Chakraborty, D. B., …Jha, S. (2021). Dopamine induces functional extracellular traps in microglia. iScience, 24(1), Article 101968. https://doi.org/10.1016/j.isci.2020.101968

Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, a... Read More about Dopamine induces functional extracellular traps in microglia.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain (2021)
Journal Article
Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2021). Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1), Article 5. https://doi.org/10.1186/s40478-020-01109-y

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this s... Read More about Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.