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Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors (2010)
Journal Article
Pires, I. M., Ward, T. H., & Dive, C. (2010). Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. British Journal of Pharmacology, 159(6), 1326-1338. https://doi.org/10.1111/j.1476-5381.2009.00607.x

Background and purpose: Checkpoint kinase 2 (CHK2) is activated by DNA damage and can contribute to p53 stabilization, modulating growth arrest and/or apoptosis. We investigated the contribution of CHK2 to oxaliplatin-mediated toxicity in a colorecta... Read More about Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.

Iron(III) and Zinc(II) calixarene complexes: Synthesis, structural studies, and use as procatalysts for ε-caprolactone polymerization (2010)
Journal Article
Arbaoui, A., Redshaw, C., Elsegood, M. R. J., Wright, V. E., Yoshizawa, A., & Yamato, T. (2010). Iron(III) and Zinc(II) calixarene complexes: Synthesis, structural studies, and use as procatalysts for ε-caprolactone polymerization. Chemistry - An Asian Journal, 5(3), 621-633. https://doi.org/10.1002/asia.200900514

Treatment of the heterobimetallic iron(II) alkoxides [(THF)MFe(OtBu)3]2 with p-tert-butylcalix[4]areneH4 (L1H4) affords the oxo-bridged diiron(III) complexes {Fe[M(NCMe)x]2L1}2(μ-O), M=Na, x=2 1⋅8(CH3CN), M= K, x=3 2⋅3.5(CH3CN); similar use of p-tert... Read More about Iron(III) and Zinc(II) calixarene complexes: Synthesis, structural studies, and use as procatalysts for ε-caprolactone polymerization.

Reconstructing the ups and downs of primate brain evolution: Implications for adaptive hypotheses and Homo floresiensis (2010)
Journal Article
Montgomery, S. H., Capellini, I., Barton, R. A., & Mundy, N. I. (2010). Reconstructing the ups and downs of primate brain evolution: Implications for adaptive hypotheses and Homo floresiensis. BMC biology, 8(1), 9. https://doi.org/10.1186/1741-7007-8-9

Background: Brain size is a key adaptive trait. It is often assumed that increasing brain size was a general evolutionary trend in primates, yet recent fossil discoveries have documented brain size decreases in some lineages, raising the question of... Read More about Reconstructing the ups and downs of primate brain evolution: Implications for adaptive hypotheses and Homo floresiensis.

A perceptually relevant approach to ringing region detection (2010)
Journal Article
Liu, H., Klomp, N., & Heynderickx, I. (2010). A perceptually relevant approach to ringing region detection. IEEE Transactions on Image Processing, 19(6), 1414-1426. https://doi.org/10.1109/tip.2010.2041406

An efficient approach toward a no-reference ringing metric intrinsically exists of two steps: first detecting regions in an image where ringing might occur, and second quantifying the ringing annoyance in these regions. This paper presents a novel ap... Read More about A perceptually relevant approach to ringing region detection.

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability (2010)
Journal Article
Pires, I. M., Bencokova, Z., Milani, M., Folkes, L. K., Li, J.-L., Stratford, M. R., Harris, A. L., & Hammond, E. M. (2010). Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Research, 70(3), 925-935. https://doi.org/10.1158/0008-5472.CAN-09-2715

Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis. Severe hypoxia causes replication arrest independent of S-phase checkpoint, DNA damage respon... Read More about Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Mapping hydraulic biotopes using terrestrial laser scan data of water surface properties (2010)
Journal Article
Milan, D., Heritage, G., Large, A., & Entwistle, N. (2010). Mapping hydraulic biotopes using terrestrial laser scan data of water surface properties. Earth surface processes and landforms : the journal of the British Geomorphological Research Group, 35(8), 918-931. https://doi.org/10.1002/esp.1948

For more than a decade, habitat mapping using biotopes (in-channel hydraulically-defined habitats) has underpinned aquatic conservation in the UK through (a) providing baseline information on system complexity and (b) allowing environmental and ecolo... Read More about Mapping hydraulic biotopes using terrestrial laser scan data of water surface properties.

Optimizing strategic behaviour in a dynamic setting in professional team sports (2010)
Journal Article
Dobson, S., & Goddard, J. (2010). Optimizing strategic behaviour in a dynamic setting in professional team sports. European journal of operational research, 205(3), 661-669. https://doi.org/10.1016/j.ejor.2010.01.024

This article develops a dynamic game-theoretic model of optimizing strategic behaviour by football (soccer) teams. Teams choose between defensive and attacking formations and between a non-violent and a violent playing style, and can vary these choic... Read More about Optimizing strategic behaviour in a dynamic setting in professional team sports.

Molecular phylogeny, morphology and bioacoustics reveal five additional species of arboreal microhylid frogs of the genus Anodonthyla from Madagascar (2010)
Journal Article
Vences, M., Glaw, F., Köhler, J., & Wollenberg, K. C. (2010). Molecular phylogeny, morphology and bioacoustics reveal five additional species of arboreal microhylid frogs of the genus Anodonthyla from Madagascar. Contributions to Zoology, 79(1), 1-32. https://doi.org/10.1163/18759866-07901001

We provide a partial revision of the microhylid frogs of the genus Anodonthyla, endemic to Madagascar, based on comprehensive molecular, bioacoustic and morphological data sets that include newly collected specimens from multiple localities. The mole... Read More about Molecular phylogeny, morphology and bioacoustics reveal five additional species of arboreal microhylid frogs of the genus Anodonthyla from Madagascar.

Providing context to the global code of practice for recreational fisheries (2010)
Journal Article
Arlinghaus, R., Cooke, S. J., & Cowx, I. G. (2010). Providing context to the global code of practice for recreational fisheries. Fisheries Management and Ecology, 17(2), 146-156. https://doi.org/10.1111/j.1365-2400.2009.00696.x

An in-depth explanation of selected content of the European Inland Fisheries Advisory Commission's 'Code of Practice for Recreational Fisheries' (CoP) is presented. The focus is on core areas that were intensely debated in the drafting the CoP. These... Read More about Providing context to the global code of practice for recreational fisheries.

Responses of three Muslim majority primary schools in England to the Islamic faith of their pupils (2010)
Journal Article
Ipgrave, J., Miller, J., & Hopkins, P. (2010). Responses of three Muslim majority primary schools in England to the Islamic faith of their pupils. Journal of international migration and integration = Revue de l'intégration et de la migration internationele, 11(1), 73-89. https://doi.org/10.1007/s12134-009-0119-7

This paper considers the responses of three English primary schools to the education of their Muslim pupils. It begins by setting out the context of discussion about Muslims and education in Europe as well as by describing some of the structural and... Read More about Responses of three Muslim majority primary schools in England to the Islamic faith of their pupils.

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain (2010)
Journal Article
Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., …Wharton, S. B. (2010). Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36(1), 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

Aims: Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken... Read More about Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.

Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review (2010)
Journal Article
Johnson, M. J., Oxberry, S. G., Cleland, J. G., & Clark, A. L. (2010). Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review. European journal of heart failure, 12(2), 137-147. https://doi.org/10.1093/eurjhf/hfp194

AIMS: Chronic breathlessness is a major symptom for patients with compensated chronic heart failure (CHF) and its impact is different to the breathlessness resulting from pulmonary oedema. This systematic review aims to establish which tools have bee... Read More about Measurement of breathlessness in clinical trials in patients with chronic heart failure: the need for a standardized approach: a systematic review.

An 80 million year oceanic redox history from Permian to Jurassic pelagic sediments of the Mino-Tamba terrane, SW Japan, and the origin of four mass extinctions (2010)
Journal Article
Wignall, P. B., Bond, D. P., Kuwahara, K., Kakuwa, Y., Newton, R. J., & Poulton, S. W. (2010). An 80 million year oceanic redox history from Permian to Jurassic pelagic sediments of the Mino-Tamba terrane, SW Japan, and the origin of four mass extinctions. Global and planetary change, 71(1-2), 109-123. https://doi.org/10.1016/j.gloplacha.2010.01.022

Fabric and pyrite framboid size analysis of Permian to Jurassic samples from the Mino-Tamba terrane of Japan provide an 80myr redox history from the Panthalassa Ocean. Fully oxygenated conditions dominated but were punctuated by three phases of anoxi... Read More about An 80 million year oceanic redox history from Permian to Jurassic pelagic sediments of the Mino-Tamba terrane, SW Japan, and the origin of four mass extinctions.

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming (2010)
Journal Article
Hansen, A., Henderson, S., Lagos, D., Nikitenko, L., Coulter, E., Roberts, S., Gratrix, F., Plaisance, K., Renne, R., Bower, M., Kellam, P., & Boshoff, C. (2010). KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Genes & development, 24(2), 195-205. https://doi.org/10.1101/gad.553410

Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation of genes associated with blood vessel endothelial cells (BECs). Conseq... Read More about KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Shearing particle monolayers: Strain-rate frequency superposition (2010)
Journal Article
Zang, D., Langevin, D., Binks, B. P., & Wei, B. (2010). Shearing particle monolayers: Strain-rate frequency superposition. Physical review. E, Statistical, nonlinear, and soft matter physics, 81(1), 011604. https://doi.org/10.1103/PhysRevE.81.011604

We report surface shear rheological measurements on monolayers of silica nanoparticles at the air-water interface. We have used the method of strain-rate frequency superposition (SRFS) to characterize the structural relaxation. We show that the rheol... Read More about Shearing particle monolayers: Strain-rate frequency superposition.

Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies (2010)
Journal Article
Alonso, C. M. A., Palumbo, A., Bullous, A. J., Pretto, F., Neri, D., & Boyle, R. W. (2010). Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies. Bioconjugate chemistry, 21(2), 302-313. https://doi.org/10.1021/bc9003537

Synthesis of three new cationic thiol-reactive maleimide-porphyrin derivatives and their use in site-specific conjugation to monoclonal antibodies is reported. The selective reactivity toward thiols is demonstrated using competition experiments, wher... Read More about Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies.

Understanding the international student experience (2010)
Book
Montgomery, C. (2010). Understanding the international student experience. Palgrave Macmillan

Presents a contemporary approach to the experience of international students in Higher Education. Using empirical and qualitative data, the book explores their social and cultural context and its impact on their learning experience.

Metal catalysts for ε-caprolactone polymerisation (2010)
Journal Article
Arbaoui, A., & Redshaw, C. (2010). Metal catalysts for ε-caprolactone polymerisation. Polymer chemistry, 1(6), 801-826. https://doi.org/10.1039/b9py00334g

Economic pressure, environmental issues and ever increasing demand are driving the shift from oil-based polymers to those available from renewable resources. Ring opening polymerisation of cyclic esters is currently a topical field with metal complex... Read More about Metal catalysts for ε-caprolactone polymerisation.

Developing integrated rural tourism : actor practices in the English/Welsh border (2010)
Journal Article
Saxena, G., & Ilbery, B. (2010). Developing integrated rural tourism : actor practices in the English/Welsh border. Journal of rural studies, 26(3), 260-271. https://doi.org/10.1016/j.jrurstud.2009.12.001

This paper examines community attitudes and distinctive practices that shape local responses to integrated rural tourism (IRT) development in the lagging rural region of the English/Welsh border area. The focus is on how actors acquire attributes as... Read More about Developing integrated rural tourism : actor practices in the English/Welsh border.