All Outputs (55)

Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets (2020)
Journal Article
Aburima, A., Berger, M., Spurgeon, B. E., Webb, B. A., Wraith, K. S., Febbraio, M., …Naseem, K. M. (2021). Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets. Blood, 137(5), 678-689. https://doi.org/10.1182/blood.2020005382

Thrombospondin-1 (TSP-1) is released by platelets upon activation and can increase platelet activation, but its role in hemostasis in vivo is unclear. We show that TSP-1 is a critical mediator of hemostasis that promotes platelet activation by modula... Read More about Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.

Hiding in Plain Sight-Ancient Chinese Anatomy (2020)
Journal Article
Shaw, V., Diogo, R., & Winder, I. C. (2020). Hiding in Plain Sight-Ancient Chinese Anatomy. Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, https://doi.org/10.1002/ar.24503

For thousands of years, scientists have studied human anatomy by dissecting bodies. Our knowledge of their findings is limited, however, both by the subsequent loss of many of the oldest texts, and by a tendency towards a Eurocentric perspective in m... Read More about Hiding in Plain Sight-Ancient Chinese Anatomy.

Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2020). Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes. Cardiology, 145(9), 553-561. https://doi.org/10.1159/000509180

© 2020 S. Karger AG, Basel. All rights reserved. Objective: To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. Methods: 1,056 acute coronary syndrome (ACS) sur... Read More about Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes.

miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review (2020)
Journal Article
Abdalla, M., Deshmukh, H., Atkin, S. L., & Sathyapalan, T. (2020). miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review. Life Sciences, 259, https://doi.org/10.1016/j.lfs.2020.118174

© 2020 Elsevier Inc. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of the reproductive age. PCOS is commonly manifested as ovulatory dysfunction, clinical and biochemical excess androgen level, and polycystic ov... Read More about miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review.

Microplastic contamination of drinking water: a systematic review. (2020)
Journal Article
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: a systematic review. PLoS ONE, 15(7 July), Article e0236838. https://doi.org/10.1371/journal.pone.0236838

Background Microplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water. Objective To undertake a systematic review of MP contamination of drinking water... Read More about Microplastic contamination of drinking water: a systematic review..

Anatomical variations of the circle of Willis and their prevalence, with a focus on the posterior communicating artery: A literature review and meta-analysis (2020)
Journal Article
Jones, J. D., Castanho, P., Bazira, P., & Sanders, K. (2021). Anatomical variations of the circle of Willis and their prevalence, with a focus on the posterior communicating artery: A literature review and meta-analysis. Clinical Anatomy, 34(7), 978-990. https://doi.org/10.1002/ca.23662

The circle of Willis is an anastomotic network of arteries surrounding the base of the brain, providing collateral circulation to prevent ischemia. It has, however, long been established that it exhibits considerable anatomical variation when compare... Read More about Anatomical variations of the circle of Willis and their prevalence, with a focus on the posterior communicating artery: A literature review and meta-analysis.

Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit (2020)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., …Sathyapalan, T. (2020). Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit. Diabetes Care, 43(9), 2153-2160. https://doi.org/10.2337/dc20-0738

OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore the U.K. real-world experience of FSL and the impact on glycemic control,... Read More about Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit.

Implementation of geriatric assessment in oncology settings: A systematic realist review (2020)
Journal Article
McKenzie, G. A., Bullock, A. F., Greenley, S. L., Lind, M. J., Johnson, M. J., & Pearson, M. (2021). Implementation of geriatric assessment in oncology settings: A systematic realist review. Journal of Geriatric Oncology, 12(1), 22-33. https://doi.org/10.1016/j.jgo.2020.07.003

Older adults with cancer are more likely to have worse clinical outcomes than their younger counterparts, and shared decision-making can be difficult, due to both complexity from adverse ageing and under-representation in clinical trials. Geriatric a... Read More about Implementation of geriatric assessment in oncology settings: A systematic realist review.

Clay-Based Modeling in the Anatomist's Toolkit: A Systematic Review (2020)
Journal Article
Curlewis, K., Leung, B., Perera, M., Bazira, P. J., & Sanders, K. A. (2021). Clay-Based Modeling in the Anatomist's Toolkit: A Systematic Review. Anatomical Sciences Education, 14(2), 252-262. https://doi.org/10.1002/ase.1996

© 2020 The Authors. Anatomical Sciences Education published by Wiley Periodicals LLC on behalf of American Association for Anatomy Anatomical education has suffered from reduced teaching time and poor availability of staff and resources over the past... Read More about Clay-Based Modeling in the Anatomist's Toolkit: A Systematic Review.

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome (2020)
Journal Article
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020). The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome. Endocrine Connections, 9(6), 563-569. https://doi.org/10.1530/EC-20-0173

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managin... Read More about The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

Acupuncture in the Management of Trigeminal Neuralgia (2020)
Journal Article
Edwards, J., & Shaw, V. (2021). Acupuncture in the Management of Trigeminal Neuralgia. Acupuncture in Medicine, 39(3), 192-199. https://doi.org/10.1177/0964528420924042

Aims To assess the standing of acupuncture as a clinical tool in the management of trigeminal neuralgia against the current first-line drug and the most effective surgery. Methods Data regarding efficacy, side effects, and cost were compiled for... Read More about Acupuncture in the Management of Trigeminal Neuralgia.

Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective (2020)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2020). Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. International Journal of Environmental Research and Public Health, 17(11), Article 4094. https://doi.org/10.3390/ijerph17114094

Intense sweeteners (IS) are often marketed as a healthier alternative to sugars, with the potential to aid in combating the worldwide rise of diabetes and obesity. However, their use has been counterintuitively associated with impaired glucose homeos... Read More about Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective.

Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery (2020)
Journal Article
Deshmukh, H., Aylward, L. L., Rose, M., Fernandes, A., Sedman, P., Thatcher, N. J., …Sathyapalan, T. (2020). Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery. Clinical Endocrinology, 93(3), 280-287. https://doi.org/10.1111/cen.14257

Introduction The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo‐p‐dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their concentration following bariat... Read More about Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.

Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels (2020)
Journal Article
Jones, P., Lucock, M., Martin, C., Thota, R., Garg, M., Yates, Z., …Beckett, E. (2020). Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels. Nutrients, 12(5), Article 1455. https://doi.org/10.3390/nu12051455

Psychological concerns of Indian women with breast cancer in different national contexts: A systematic review and mixed-methods synthesis (2020)
Journal Article
Daniel, S., Clark, J., Gnanapragasam, S., Venkateswaran, C., & Johnson, M. J. (in press). Psychological concerns of Indian women with breast cancer in different national contexts: A systematic review and mixed-methods synthesis. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2019-002076

© 2020 Author(s). Background: Breast cancer is becoming the most common cancer among women of Indian origin. However, little is known about the psychological impact of the disease and its treatment among this population. Aim: To improve understanding... Read More about Psychological concerns of Indian women with breast cancer in different national contexts: A systematic review and mixed-methods synthesis.

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis (2020)
Journal Article
Bullock, A. F., Greenley, S. L., McKenzie, G. A., Paton, L. W., & Johnson, M. J. (2020). Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis. European journal of clinical nutrition, 74, 1519–1535. https://doi.org/10.1038/s41430-020-0629-0

© 2020, The Author(s). Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however... Read More about Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.

Physical activity and nutrition interventions for older adults with cancer: a systematic review (2020)
Journal Article
Forbes, C. C., Swan, F., Greenley, S. L., Lind, M., & Johnson, M. J. (2020). Physical activity and nutrition interventions for older adults with cancer: a systematic review. Journal of cancer survivorship : research and practice, 14(5), 689-711. https://doi.org/10.1007/s11764-020-00883-x

Purpose: The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods: We... Read More about Physical activity and nutrition interventions for older adults with cancer: a systematic review.

Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization (2020)
Journal Article
Sturmey, R. G., & Leary, C. (2020). Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization. Molecular Human Reproduction, 26(4), 277-287. https://doi.org/10.1093/molehr/gaaa015

The pattern of metabolism by early embryos in vitro has been linked to a range of phenotypes, including viability. However, the extent to which metabolic function of embryos is modified by specific methods used during ART has yet to be fully describ... Read More about Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization.

Online Assessment of Applied Anatomy Knowledge: The Effect of Images on Medical Students' Performance (2020)
Journal Article
Sagoo, M. G., Vorstenbosch, M. A., Bazira, P. J., Ellis, H., Kambouri, M., & Owen, C. (2021). Online Assessment of Applied Anatomy Knowledge: The Effect of Images on Medical Students' Performance. Anatomical Sciences Education, 14(3), 342-351. https://doi.org/10.1002/ase.1965

Anatomical examinations have been designed to assess topographical and/or applied knowledge of anatomy with or without the inclusion of visual resources such as cadaveric specimens or images, radiological images, and/or clinical photographs. Multimed... Read More about Online Assessment of Applied Anatomy Knowledge: The Effect of Images on Medical Students' Performance.

Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort (2020)
Journal Article
Ferraris, C., Turner, A., Kaur, K., Piper, J., Veysey, M., Lucock, M., & Beckett, E. L. (2020). Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. Nutrients, 12(4), 1056. https://doi.org/10.3390/nu12041056

A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a signific... Read More about Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort.