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Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort

Ferraris, Celeste; Turner, Alexandria; Kaur, Kiranjit; Piper, Jessica; Veysey, Martin; Lucock, Mark; Beckett, Emma L.

Authors

Celeste Ferraris

Alexandria Turner

Kiranjit Kaur

Jessica Piper

Martin Veysey

Mark Lucock

Emma L. Beckett



Abstract

A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hypertension and cardiovascular disease; however, this does not fully explain the risk. Research into the influence of salt taste genetics on diet quality is yet to be undertaken and current research on indicators of health is limited and mixed in the direction of associations. Therefore, a secondary analysis of data from a well-characterised elderly cohort (the cross-sectional Retirement Health and Lifestyle Study, n = 536) was conducted to explore relationships between the salt taste-related SNP TRPV1-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey’s HSD post hoc tests. No association was found between the TRPV1-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to TRPV1-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the TRPV1-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the TRPV1-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health. View Full-Text

Journal Article Type Article
Publication Date Apr 10, 2020
Journal Nutrients
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 4
Pages 1056
APA6 Citation Ferraris, C., Turner, A., Kaur, K., Piper, J., Veysey, M., Lucock, M., & Beckett, E. L. (2020). Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. Nutrients, 12(4), 1056. https://doi.org/10.3390/nu12041056
DOI https://doi.org/10.3390/nu12041056
Keywords Salt; Taste; TRPV1 gene; rs806500; Dietary; Biomarker; Elderly; Nutrigenetics
Publisher URL https://www.mdpi.com/2072-6643/12/4/1056

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Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).





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