Molecular Analysis at Relapse of Patients Treated on the Ibrutinib and Rituximab Arm of the National Multi-Centre Phase III FLAIR Study in Previously Untreated CLL Patients
(2023)
Presentation / Conference Contribution
Sarma, A., Evans, C., Dalal, S., Webster, N., Rawstron, A., Shingles, J., …Hillmen, P. (2023). Molecular Analysis at Relapse of Patients Treated on the Ibrutinib and Rituximab Arm of the National Multi-Centre Phase III FLAIR Study in Previously Untreated CLL Patients. Blood, 142(Supplement 1), 4636-4636. https://doi.org/10.1182/blood-2023-188597
All Outputs (20505)
Using Peripheral Blood (PB) Measurable Residual Disease (MRD) Levels to Predict <0.01% Bone Marrow Disease (BM uMRD4): Identification of Effective PB Targets for CLL Treatment Cessation in the Ibrutinib+Venetoclax Arm of the FLAIR Trial (2023)
Presentation / Conference Contribution
Rawstron, A., Webster, N., Dalal, S., de Tute, R. M., Bell, S., Cairns, D. A., Girvan, S., Greatorex, N., Hockaday, A., Jackson, S., Phillips, D., Stones, D., Allsup, D., Bloor, A. J. C., Sarma, A., Varghese, A. M., Munir, T., & Hillmen, P. Using Peripheral Blood (PB) Measurable Residual Disease (MRD) Levels to Predict <0.01% Bone Marrow Disease (BM uMRD4): Identification of Effective PB Targets for CLL Treatment Cessation in the Ibrutinib+Venetoclax Arm of the FLAIR Trial. Presented at 65th ASH Annual Meeting and Exposition, San Diego, CA
Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study (2023)
Presentation / Conference Contribution
Hillmen, P., Cairns, D. A., Bloor, A. J. C., Allsup, D., Cwynarski, K., Pettitt, A., Paneesha, S., Fox, C. P., Eyre, T. A., Forconi, F., Elmusharaf, N., Kennedy, B., Gribben, J. G., Pemberton, N., Sheehy, O., Preston, G., Schuh, A., Howard, D., Hockaday, A., Jackson, S., …Munir, T. Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study. Presented at 65th ASH Annual Meeting and Exposition, San Diego, CAIntroduction: Ibrutinib (I), an irreversible Btk inhibitor, and venetoclax (V), a Bcl-2 inhibitor, improve CLL outcomes in trials compared to chemoimmunotherapy. I and V target two key pathophysiological pathways in CLL and should be synergistic. Thi... Read More about Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study.
Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells (2023)
Journal Article
Ruscillo, F., Zhang, K., Ismail, M. S., Hughes, K. J., Ingham, D. B., Ma, L., & Pourkashanian, M. (2023). Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells. Energies, 16(22), Article 7601. https://doi.org/10.3390/en16227601This study aims to experimentally evaluate the impact of a double-sided microporous layer coating on gas diffusion layers in terms of their key properties and fuel cell performance, in comparison to conventional single-sided coated gas diffusion laye... Read More about Characterisation of Novel and High Performing Double-Sided Microporous-Layers-Coated Gas Diffusion Layers for Polymer Electrolyte Membrane Fuel Cells.
BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping (2023)
Journal Article
Clark, J., Salins, N., Pearson, M., Spathis, A., Currow, D. C., Williams, S., & Johnson, M. (2023). BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping. PLoS ONE, 18(11 November), Article e0293918. https://doi.org/10.1371/journal.pone.0293918Background Breathlessness that persists despite treatment of causal disease(s) is disabling, associated with high therapy-related costs and poor socioeconomic outcomes. Low resource countries bear a disproportionate burden of respiratory problems, of... Read More about BREATHLEssness in INDIA (BREATHE-INDIA)–Study protocol for the co-design of a community breathlessness intervention in India using realist methods and intervention mapping.
Conversations on grief and hope: a collaborative autoethnographic account exploring the lifeworlds of international youth engaged with climate action (2023)
Journal Article
Jones, L., Parsons, K. J., Halstead, F., Ngoc Nguyen, D. N., Pham, H. T., Pham, D. L., …Parsons, D. R. (2023). Conversations on grief and hope: a collaborative autoethnographic account exploring the lifeworlds of international youth engaged with climate action. Journal of the British Academy, 11(S3), 69-117. https://doi.org/10.5871/JBA/011S3.069This paper explores the lifeworlds of international youth involved in climate and/or environmental social action, narratives that have been largely absent from a literature that has tended to focus on ‘traditional’ youth activists located in the urba... Read More about Conversations on grief and hope: a collaborative autoethnographic account exploring the lifeworlds of international youth engaged with climate action.
Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4587991Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.
A Chandra Study of the NGC 7618/UGC 12491 Major Group Merger at Apogee: Multiple Cold Fronts, Boxy Wings, Filaments, and Arc-shaped Slingshot Tails (2023)
Journal Article
Machacek, M. E., Jones, C., Kraft, R. P., Forman, W. R., Roediger, E., Sheardown, A., & Wan, J. T. (2023). A Chandra Study of the NGC 7618/UGC 12491 Major Group Merger at Apogee: Multiple Cold Fronts, Boxy Wings, Filaments, and Arc-shaped Slingshot Tails. The Astrophysical journal, 958(1), Article 93. https://doi.org/10.3847/1538-4357/ad00b2Analyses of major group mergers are key to understanding the evolution of large-scale structure in the Universe and the microphysical properties of the hot gas in these systems. We present imaging and spectral analyses of deep Chandra observations of... Read More about A Chandra Study of the NGC 7618/UGC 12491 Major Group Merger at Apogee: Multiple Cold Fronts, Boxy Wings, Filaments, and Arc-shaped Slingshot Tails.
Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios (2023)
Thesis
Mincarelli, L. F. (2023). Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4436320Climate change and plastic pollution are both pressing environmental issues. Little is known, however, about the combined effect of climate change conditions (such as global warming and ocean acidification) and plastic contaminants (such as the addit... Read More about Sex-related responses of blue mussels to the plasticiser DEHP under climate change scenarios.
GTC Follow-up Observations of Very Metal-poor Star Candidates from DESI (2023)
Journal Article
Allende Prieto, C., Aguado, D. S., González Hernández, J. I., Rebolo, R., Najita, J., Manser, C. J., …Zou, H. (2023). GTC Follow-up Observations of Very Metal-poor Star Candidates from DESI. The Astrophysical journal, 957(2), Article 76. https://doi.org/10.3847/1538-4357/acfa96The observations from the Dark Energy Spectroscopic Instrument (DESI) will significantly increase the numbers of known extremely metal-poor stars by a factor of ~10, improving the sample statistics to study the early chemical evolution of the Milky W... Read More about GTC Follow-up Observations of Very Metal-poor Star Candidates from DESI.
Comprehensive process simulation of a biomass-based hydrogen production system through gasification within the BECCS concept in a commercial two-stage fixed bed gasifier (2023)
Journal Article
Rabea, K., Michailos, S., Hughes, K. J., Ingham, D., & Pourkashanian, M. (2023). Comprehensive process simulation of a biomass-based hydrogen production system through gasification within the BECCS concept in a commercial two-stage fixed bed gasifier. Energy Conversion and Management, 298, Article 117812. https://doi.org/10.1016/j.enconman.2023.117812Hydrogen production through biomass gasification coupled with carbon capture has the potential to be a net negative emission process. Among the different designs of biomass gasifiers, the two-stage fixed bed gasifier has proved its ability to produce... Read More about Comprehensive process simulation of a biomass-based hydrogen production system through gasification within the BECCS concept in a commercial two-stage fixed bed gasifier.
Brazil’s Strategic Diplomacy Failures and Foreign Policy Underachievement under Bolsonaro (2023)
Journal Article
Doctor, M. (2023). Brazil’s Strategic Diplomacy Failures and Foreign Policy Underachievement under Bolsonaro. Revista Brasileira de Política Internacional, 66(1), https://doi.org/10.1590/0034-7329202300111The article examines the extent of foreign policy continuity or change and level of foreign policy achievement or underachievement during the Bolsonaro presidency. These are analysed through the lens of ‘strategic diplomacy’, a concept that considers... Read More about Brazil’s Strategic Diplomacy Failures and Foreign Policy Underachievement under Bolsonaro.
Primary Care in the world of Integrated Care Systems: Education and Training for General Practice (2023)
Journal Article
Al-bedaery, R., Rosenthal, J., Protheroe, J., Reeve, J., & Ibison, J. (2023). Primary Care in the world of Integrated Care Systems: Education and Training for General Practice. Future Healthcare Journal, 10(3), 253-258. https://doi.org/10.7861/fhj.2023-0073Here, we discuss the required education and training for the emergent and evolving roles of GPs and other healthcare professionals within Integrated Care Systems (ICSs). We underscore the importance of collaborative skills for all medical specialties... Read More about Primary Care in the world of Integrated Care Systems: Education and Training for General Practice.
A Portable Multi-user Cross-Platform Virtual Reality Platform for School Teaching in Malawi (2023)
Presentation / Conference Contribution
Kambili-Mzembe, F., & Gordon, N. A. A Portable Multi-user Cross-Platform Virtual Reality Platform for School Teaching in Malawi. Presented at International Conference on Immersive Learning 2023, San Luis Obispo, USAThis paper discusses and evaluates a self-contained portable multi-user cross-platform Virtual Reality (VR) setup that was devised and configured using off the shelf technologies and devices. This paper exemplifies how some fundamental challenges lik... Read More about A Portable Multi-user Cross-Platform Virtual Reality Platform for School Teaching in Malawi.
A facile and sensitive hexahomotrioxacalix[3]arene-based fluorescent sensor for the detection of trace amounts of 2,4,6-trinitrophenol (2023)
Journal Article
Liu, Y. L., Wu, L. F., Wu, C., Rahman, S., Alodhayb, A., Redshaw, C., Georghiou, P. E., & Yamato, T. (2024). A facile and sensitive hexahomotrioxacalix[3]arene-based fluorescent sensor for the detection of trace amounts of 2,4,6-trinitrophenol. The Science of the total environment, 908, Article 168209. https://doi.org/10.1016/j.scitotenv.2023.168209Nitroaromatic compounds are common explosives and toxic pollutants, the selective and sensitive detection of which is of great importance. Herein, a facile and sensitive fluorescent sensor L was constructed for the sensing of TNP based on the hexahom... Read More about A facile and sensitive hexahomotrioxacalix[3]arene-based fluorescent sensor for the detection of trace amounts of 2,4,6-trinitrophenol.
Progress report on PhD research project "Using on-farm technologies to manage soil carbon and crops: understanding farming knowledges and practices in the deployment of sustainability technologies" (2023)
Presentation / Conference Contribution
Morton, L. (2023, October). Progress report on PhD research project "Using on-farm technologies to manage soil carbon and crops: understanding farming knowledges and practices in the deployment of sustainability technologies"The project will critically analyse the impacts and implications of technologies in complex on-farm environments.
From the conference and beyond: collaborative writing with the journal of learning development in higher education and the learning development community (2023)
Journal Article
Buckley, C., Fallin, L., Grayson, N., Loughlin, E., Lowe, T., Malone, C., Morley, C., Sedghi, G., & Syska, A. (2023). From the conference and beyond: collaborative writing with the journal of learning development in higher education and the learning development community. Journal of Learning Development in Higher Education, https://doi.org/10.47408/jldhe.vi29.1142This workshop set out the process of collaborative writing explored by the JLDHE editorial teams in partnership with the ALDinHE community at and following ALDCon’22 through The Collaborative Conference Proceedings and Reflections. We discussed how t... Read More about From the conference and beyond: collaborative writing with the journal of learning development in higher education and the learning development community.
Learning development in a time of disruption (2023)
Journal Article
Fallin, L. (2023). Learning development in a time of disruption. Journal of Learning Development in Higher Education, https://doi.org/10.47408/jldhe.vi29.1078The Covid-19 Pandemic had (and continues to have) a significant worldwide impact on Higher Education (Watermeyer et al., 2021; Sharaievska et al., 2022). How Learning Development responded to this challenge varied considerably across the sector. Man... Read More about Learning development in a time of disruption.
A manifesto for the metaverse: opportunities and challenges for learning development (2023)
Presentation / Conference Contribution
Buckley, C., Holley, D., & Fallin, L. (2023). A manifesto for the metaverse: opportunities and challenges for learning development. Journal of Learning Development in Higher Education, https://doi.org/10.47408/jldhe.vi29.1127Drawing upon a section of the co-created learning development (LD) Manifesto (ALDinHE, 2018), in this workshop we invite participants to come and be creative-and imagine beyond what learning developers do now into what they may do in the future, insp... Read More about A manifesto for the metaverse: opportunities and challenges for learning development.
Co-creating LearnHigher: demystifying and shaping what we do (2023)
Journal Article
Beeson, H., Dettmer, J., Fallin, L., Key, L., & Ramakrishnan, S. (2023). Co-creating LearnHigher: demystifying and shaping what we do. Journal of Learning Development in Higher Education, https://doi.org/10.47408/jldhe.vi29.1090Established in 2005, the LearnHigher platform provides high quality, peer-evaluated resources which support students’ learning development. It was developed through a collaborative network of 16 institutions and is overseen by a working group who sup... Read More about Co-creating LearnHigher: demystifying and shaping what we do.