All Outputs (333)

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood-Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., …Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood-Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68 + microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding r... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood-Brain Barrier Dysfunction.

Associations between multimorbidity and neuropathology in dementia: a case for considering functional cognitive disorders, psychiatric illness, and dementia mimics (2024)
Journal Article
Hamilton, C. A., Matthews, F. E., Attems, J., Donaghy, P. C., Taylor, J., & Thomas, A. J. (in press). Associations between multimorbidity and neuropathology in dementia: a case for considering functional cognitive disorders, psychiatric illness, and dementia mimics. British Journal of Psychiatry, https://doi.org/10.1192/bjp.2024.25

Cognitive impairment in older people has a variety of underlying causes. In addition to neurodegenerative causes such as Alzheimer's disease, a dementia-like cognitive disorder may appear due to non-degenerative factors. Multimorbidity has been previ... Read More about Associations between multimorbidity and neuropathology in dementia: a case for considering functional cognitive disorders, psychiatric illness, and dementia mimics.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F., Thom, J. M., …Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24, Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme (2024)
Journal Article
Victor, C. R., Gamble, L. D., Pentecost, C., Quinn, C., Charlwood, C., Matthews, F. E., & Clare, L. (2024). Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme. International journal of geriatric psychiatry, 39(1), Article e6048. https://doi.org/10.1002/gps.6048

Objectives: The increasing heterogeneity of the population of older people is reflected in an increasing number of people with dementia and carers drawn from minority ethnic groups. Data from the IDEAL study are used to compare indices of ‘living wel... Read More about Living well with dementia: An exploratory matched analysis of minority ethnic and white people with dementia and carers participating in the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., …Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk (2023)
Journal Article
Kootar, S., Huque, M. H., Kiely, K. M., Anderson, C. S., Jorm, L., Kivipelto, M., …Anstey, K. J. (2023). Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk. BMJ open, 13(9), Article e076860. https://doi.org/10.1136/bmjopen-2023-076860

Introduction Current efforts to reduce dementia focus on prevention and risk reduction by targeting modifiable risk factors. As dementia and cardiometabolic non-communicable diseases (NCDs) share risk factors, a single risk-estimating tool for dement... Read More about Study protocol for development and validation of a single tool to assess risks of stroke, diabetes mellitus, myocardial infarction and dementia: DemNCD-Risk.

Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme (2023)
Journal Article
Martyr, A., Ravi, M., Gamble, L. D., Morris, R. G., Rusted, J. M., Pentecost, C., …Clare, L. (2024). Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme. Alzheimer's & dementia, 20(1), 410-420. https://doi.org/10.1002/alz.13448

INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1... Read More about Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.

Insights into the pathological basis of dementia from population-based neuropathology studies (2023)
Journal Article
Wharton, S. B., Simpson, J. E., Ince, P. G., Richardson, C. D., Merrick, R., Matthews, F. E., & Brayne, C. (2023). Insights into the pathological basis of dementia from population-based neuropathology studies. Neuropathology and Applied Neurobiology, 49(4), Article e12923. https://doi.org/10.1111/nan.12923

The epidemiological neuropathology perspective of population and community-based studies allows unbiased assessment of the prevalence of various pathologies and their relationships to late-life dementia. In addition, this approach provides complement... Read More about Insights into the pathological basis of dementia from population-based neuropathology studies.

Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study (2023)
Journal Article
Wright, L. M., Donaghy, P. C., Burn, D. J., Taylor, J. P., O'Brien, J. T., Yarnall, A. J., …Lawson, R. A. (2023). Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study. Parkinsonism and Related Disorders, 113, Article 105762. https://doi.org/10.1016/j.parkreldis.2023.105762

Introduction: Neuropsychiatric symptoms (NPS) in Lewy body dementias (LBD) occur frequently and early in disease progression. Such symptoms are associated with worse quality of life, caregiver burden and functional limitations. Limited evidence exist... Read More about Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.

Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort (2023)
Journal Article
McCormick, E. M., Kievit, R. A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., …Knights, E. (2023). Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort. Journal of Neuroscience, 43(19), 3557-3566. https://doi.org/10.1523/JNEUROSCI.1042-22.2023

Most prior research has focused on characterizing averages in cognition, brain characteristics, or behavior, and attempting to predict differences in these averages among individuals. However, this overwhelming focus on mean levels may leave us with... Read More about Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort.

Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis (2023)
Journal Article
Iqbal, A., Richardson, C., Iqbal, Z., O’Keefe, H., Hanratty, B., Matthews, F. E., & Todd, A. (2023). Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis. BMC Geriatrics, 23(1), Article 149. https://doi.org/10.1186/s12877-023-03835-z

Background: Socioeconomic status (SES) may influence prescribing, concordance and adherence to medication regimens. This review set out to investigate the association between polypharmacy and an individual’s socioeconomic status. Methods: A systemati... Read More about Are there socioeconomic inequalities in polypharmacy among older people? A systematic review and meta-analysis.

Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection (2023)
Journal Article
Rajab, M. D., Jammeh, E., Taketa, T., Brayne, C., Matthews, F. E., Su, L., …Wang, D. (2023). Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer's Research and Therapy, 15(1), Article 47. https://doi.org/10.1186/s13195-023-01195-9

Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing neuropathological mea... Read More about Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.

Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017) (2023)
Journal Article
Maharani, A., Sinclair, D. R., Chandola, T., Bower, P., Clegg, A., Hanratty, B., …Matthews, F. E. (2023). Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017). Age and ageing, 52(3), Article afad034. https://doi.org/10.1093/ageing/afad034

Background: frailty is a condition of reduced function and health due to ageing processes and is associated with a higher risk of falls, hospitalisation, disability and mortality. Objective: to determine the relationship between household wealth and... Read More about Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017).

The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia (2023)
Journal Article
Nichols, E., Merrick, R., Hay, S. I., Himali, D., Himali, J. J., Hunter, S., …Vos, T. (2023). The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. The Lancet Healthy Longevity, 4(3), e115-e125. https://doi.org/10.1016/S2666-7568%2823%2900019-3

Background: Population-based autopsy studies provide valuable insights into the causes of dementia but are limited by sample size and restriction to specific populations. Harmonisation across studies increases statistical power and allows meaningful... Read More about The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia.

Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities (2023)
Journal Article
King, D. L., Henson, R. N., Kievit, R., Wolpe, N., Brayne, C., Tyler, L. K., …Tsvetanov, K. A. (2023). Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities. Scientific reports, 13(1), Article 978. https://doi.org/10.1038/s41598-022-27252-1

Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or exa... Read More about Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.

Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis (2023)
Journal Article
Huque, H., Eramudugolla, R., Chidiac, B., Ee, N., Ehrenfeld, L., Matthews, F. E., …Anstey, K. J. (2023). Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease, 91(4), 1231-1241. https://doi.org/10.3233/JAD-220724

Background: Despite rising interest in sex differences in dementia, it is unclear whether sex differences in dementia incidence and prevalence are apparent globally. Objective: We examine sex differences in incidence and prevalence of Any dementia, A... Read More about Could Country-Level Factors Explain Sex Differences in Dementia Incidence and Prevalence? A Systematic Review and Meta-Analysis.

Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme (2022)
Journal Article
Sabatini, S., Martyr, A., Gamble, L. D., Jones, I. R., Collins, R., Matthews, F. E., …Clare, L. (2023). Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme. Social science & medicine, 317, Article 115603. https://doi.org/10.1016/j.socscimed.2022.115603

Rationale: Research exploring social, cultural, and economic capital among people with dementia is scarce. Objective: We describe levels of social, cultural, and economic capital in people with dementia at baseline and levels of social and cultural c... Read More about Are profiles of social, cultural, and economic capital related to living well with dementia? Longitudinal findings from the IDEAL programme.

Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study (2022)
Journal Article
Roman-Urrestarazu, A., Yang, J. C., van Kessel, R., Warrier, V., Dumas, G., Jongsma, H., …Brayne, C. (2022). Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study. The Lancet Child & Adolescent Health, 6(12), 857-868. https://doi.org/10.1016/S2352-4642%2822%2900247-4

Background: Understanding how certain factors affect autism incidence can help to identify inequities in diagnostic access. We aimed to investigate the incidence of autism in England as a function of geography and sociodemographics, examining spatial... Read More about Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study.