Professor Tim Palmer's Outputs (2)

Regulation of adenosine receptor desensitisation and function (2015)
Book Chapter
Rutherford, C., & Palmer, T. M. (2015). Regulation of adenosine receptor desensitisation and function. In V. Ramkumar, & R. Paes de Carvalho (Eds.), Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects (35-53). Nova Science Publishers

© 2015 by Nova Science Publishers, Inc. All rights reserved. The ability of cells to respond to changes in extracellular concentrations of the nucleoside adenosine is determined by their complement of cell surface adenosine receptors. Four receptor s... Read More about Regulation of adenosine receptor desensitisation and function.

The future of EPAC-targeted therapies: Agonism versus antagonism (2015)
Journal Article
Parnell, E., Palmer, T. M., & Yarwood, S. J. (2015). The future of EPAC-targeted therapies: Agonism versus antagonism. Trends in Pharmacological Sciences, 36(4), 203-214. https://doi.org/10.1016/j.tips.2015.02.003

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes. Recent attention has turned to the specific regulation of EPAC... Read More about The future of EPAC-targeted therapies: Agonism versus antagonism.