Regulation of adenosine receptor desensitisation and function

Rutherford, Claire; Palmer, Timothy M.

Abstract

© 2015 by Nova Science Publishers, Inc. All rights reserved. The ability of cells to respond to changes in extracellular concentrations of the nucleoside adenosine is determined by their complement of cell surface adenosine receptors. Four receptor subtypes, termed A1, A2A, A2B and A3, have been identified that, as well as displaying distinct pharmacological characteristics, mediate their intracellular effects by coupling to defined G-protein families and other G-protein-independent pathways. A large body of research has also identified the molecular mechanisms by which adenosine receptor-derived signalling events are regulated. This has revealed that the desensitisation of closely related adenosine receptors, which bind the same agonist in vivo (i.e., adenosine) and activate the same family of G-proteins, can be regulated by unique receptor-specific mechanisms. In this chapter, we will describe the nature of these differences, and how they could potentially be exploited to enhance the therapeutically beneficial effects of adenosine receptor modulation in vivo.

Citation

Rutherford, C., & Palmer, T. M. (2015). Regulation of adenosine receptor desensitisation and function. In V. Ramkumar, & R. Paes de Carvalho (Eds.), Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects (35-53). Nova Science Publishers

• Publication Date: Sep 1, 2015
• Deposit Date: Apr 1, 2022
• Publisher: Nova Science Publishers
• Pages: 35-53
• Series Title: Pharmacology – Research, Safety Testing and Regulation
• Book Title: Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects
• ISBN: 9781634832083; 9781634831864
• Public URL: https://hull-repository.worktribe.com/output/3629588
• Publisher URL: https://novapublishers.com/shop/adenosine-signaling-mechanisms-pharmacology-functions-and-therapeutic-aspects/