Skip to main content

Research Repository

Advanced Search

Dr Paul McKeegan's Outputs (4)

Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology (2025)
Journal Article
Papachristofi, V., Mckeegan, P. J., Leese, H. J., Rotchell, J. M., & Sturmey, R. G. (2025). Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology. International Journal of Environmental Research and Public Health, 22(7), Article 1031. https://doi.org/10.3390/ijerph22071031

Triclosan (TCS) is an antimicrobial agent in a wide range of health care products. It has been found in various human bodily fluids and is a potential reproductive toxicant. However, the effect of TCS on early embryo development in mammalian species... Read More about Oocyte Exposure to Low Levels of Triclosan Has a Significant Impact on Subsequent Embryo Physiology.

Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy (2022)
Journal Article
Bruce, C., Ubhi, N., McKeegan, P., & Sanders, K. (2023). Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy. The American journal of cardiology, 188, P110-P119. https://doi.org/10.1016/j.amjcard.2022.10.059

Myocardial bridging (MB) is a congenital variant in which a segment of a coronary artery follows an atypical intramural course under a “bridge” of myocardium and is notably common in hypertrophic cardiomyopathy (HCM). This systematic review and meta-... Read More about Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy.

Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy (2021)
Journal Article
Leese, H. J., McKeegan, P., & Sturmey, R. G. (2021). Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy. International Journal of Environmental Research and Public Health, 18(18), Article 9874. https://doi.org/10.3390/ijerph18189874

Amino acids are now recognised as having multiple cellular functions in addition to their traditional role as constituents of proteins. This is well-illustrated in the early mammalian embryo where amino acids are now known to be involved in intermedi... Read More about Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy.

Metabolic regulation during early embryo development (2015)
Thesis
McKeegan, P. Metabolic regulation during early embryo development. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4216544

The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consu... Read More about Metabolic regulation during early embryo development.