Professor Alyn Morice's Projects (20)

A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough Jul 1, 2024 - Nov 30, 2024

GA43590 - GDC-6599 in Chronic Cough Jul 1, 2023 - Dec 31, 2024

NAL04-201 - Trevi Therapeutics, Inc. - Refractory Chronic Cough - 4318/0011 Feb 1, 2024 - Apr 30, 2025

HEIF: Simplifying patient information for clinical trials Aug 1, 2023 - Jul 31, 2024
Clinical trials are the main mechanism for improving patient care. They are an important source of income for the University and HUTH. The output in terms of publications and impact generated contributes greatly to the REF submission.

In order to... Read More about HEIF: Simplifying patient information for clinical trials.

Phase 2a, Randomised, Double-Blind, Placebo-Controlled, Two-Part Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetic Profiles of Inhaled Doses of NOC-100 in Adult Participants with Chronic or Acute Cough Nov 1, 2021 - Dec 31, 2023

Randomised, double-blind, parallel group. Phase 2b dose-finding, efficacy and safety study of 12-week twice daily oral administration of BAY 1817080 compared to placebo in the treatment of refractory and/or unexplained chronic cough (RUCC) Jan 1, 2021 - Feb 28, 2022

RELIEF: A Randomised, Double-blind, Placebo-Controlled, Crossover, Dose Escalation Study of BLU-5937 in subjects with Unexplained or Refractory Chronic Cough Jun 1, 2020 - Dec 31, 2020

BICS: A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease Jun 1, 2017 - May 31, 2022

Two-part, double-blind, placebo-controlled, randomized, parallel-group study - (Part 1) in healthy male volunteers to assess safety and tolerability of ascending repeated oral doses of BAY 1817080 followed (Part 2), two-way crossover administration with four-step dose titration in patients with refractory chronic cough to assess safety, tolerability and efficacy for proof of concept and dose-finding Jul 18, 2018 - Dec 31, 2019

Proof of Concept study (POC) to investigate the effect of ambroxol hydrochloride (20mg lozenges) on the cough reflex in patients with acute upper respiratory tract infection Oct 1, 2017 - Sep 30, 2018

Lavolta - A phase III, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of May 18, 2014 - Jul 31, 2017

Development Costs: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects Oct 5, 2015 - Oct 4, 2017

AX-8 Clinical Research Collaboration Jun 1, 2016 - May 31, 2018
Primary:
Study the efficacy of compound AX-8 in suppressing cough and upper airway symptoms in subjects with cough hypersensitivity syndrome.

Secondary:
Study the safety of compound AX-8.

AFFERENT14: A Study to Assess the Effect of AF-219 on Cough Reflex Sensitivity in Both Healthy and Chronic Cough Subjects Oct 5, 2015 - Jul 31, 2018

VOLCANO-2: A double-blind, placebo controlled study of the efficacy and safety of three doses of Orvepitant in subjects with chronic refractory cough Aug 1, 2017 - Dec 31, 2019

OSPREY: An Observational Study of the Phenotype and pRescribing in East Yorkshire and its relevance to the introduction of new prescribing guidelines for airways disease. Oct 1, 2016 - Dec 31, 2018

TUF: The Utility of FeNo in the differential diagnosis of chronic cough Nov 2, 2015 - Jun 1, 2018

Orbit-4: A multi-centre, randomised, double-blind, placebo-controlled study to evaluate the safety and efficacy of Pulmaquin in the management of chronic lung infections with pseudomonas aeruginosa in subjects with non-cystic fibrosis bronchiectasis, including 28 Oct 31, 2014 - Jul 31, 2018

AFFERENT12: AF219-012: A 12 week Study to assess the Efficacy and tolerability of AF 219 in subjects with treatm Mar 1, 2016 - May 31, 2018

TUSSIX: MTI-110 - A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of Serlopitant for the treatment of refractory chronic cough Dec 1, 2017 - Nov 30, 2018