Professor Michael Lind's Outputs (33)

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study (2022)
Journal Article
Curry, J., Lind, M., Short, C. E., Vandelanotte, C., Evans, H. E., Pearson, M., & Forbes, C. C. (2022). Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study. Pilot and Feasibility Studies, 8(1), Article 182. https://doi.org/10.1186/s40814-022-01129-6

Background: Lung cancer is the leading cause of cancer-related death globally. Physical activity and exercise provide unequivocal benefits to those living with and beyond lung cancer. However, few of those living with and beyond cancer meet the natio... Read More about Evaluating a web-based computer-tailored physical activity intervention for those living with and beyond lung cancer (ExerciseGuide UK): protocol for a single group feasibility and acceptability study.

Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review (2022)
Journal Article
Patterson, M., Greenley, S., Ma, Y., Bullock, A., Curry, J., Smithson, J., Lind, M., & Johnson, M. J. (2022). Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review. BMJ supportive & palliative care, Article 003492. https://doi.org/10.1136/bmjspcare-2021-003492

Background: Parenteral nutrition (PN) and palliative venting gastrostomies (PVG) are two interventions used clinically to manage inoperable malignant bowel obstruction (MBO); however, little is known about their role in clinical and quality-of-life o... Read More about Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review.

Exploring hypoxic biology to improve radiotherapy outcomes (2022)
Journal Article
Li, C., Wiseman, L., Okoh, E., Lind, M., Roy, R., Beavis, A., & Monteiro dos Santos Pires, I. (2022). Exploring hypoxic biology to improve radiotherapy outcomes. Expert Reviews in Molecular Medicine, 24, Article E21. https://doi.org/10.1017/erm.2022.14

Ionising radiotherapy is a well-established, effective cancer treatment modality, whose efficacy has improved with the application of newer technological modalities. However, patient outcomes are governed and potentially limited by aspects of tumour... Read More about Exploring hypoxic biology to improve radiotherapy outcomes.

Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer (2021)
Thesis
McKenzie, G. A. G. Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4192792

Introduction: Older adults with cancer have worse outcomes than their younger counterparts, including higher postoperative complications, chemotherapy toxicity and treatment allocation to best supportive care. Oncogeriatric assessment (OGA) can provi... Read More about Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer.

CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings (2020)
Journal Article
Swan, F., Chen, H., Forbes, C. C., Johnson, M. J., & Lind, M. (in press). CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2020.09.026

Background: Older people with lung cancer are often frail and unfit due to their cancer and co-morbidities and may tolerate cancer treatments poorly. Physical activity (PA) and a healthy diet offer quality of life benefit to people with cancer before... Read More about CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings.

The care of older cancer patients in the United Kingdom (2020)
Journal Article
Gomes, F., Lewis, A., Morris, R., Parks, R., Kalsi, T., Babic-Illamn, G., Baxter, M., Colquhoun, K., Rodgers, L., Smith, E., Greystoke, A., Bayman, N., Cree, A., Ng, C., DE Liguori Carino, N., Basile, S., Moore, J., Merchant, Z., Swinson, D., Parbhoo, A., …Simcock, R. (2020). The care of older cancer patients in the United Kingdom. ecancermedicalscience, 14, Article 1101. https://doi.org/10.3332/ECANCER.2020.1101

© 2020 the authors. The ageing population poses new challenges globally. Cancer care for older patients is one of these challenges, and it has a significant impact on societies. In the United Kingdom (UK), as the number of older cancer patients incre... Read More about The care of older cancer patients in the United Kingdom.

Implementation of geriatric assessment in oncology settings: A systematic realist review (2020)
Journal Article
McKenzie, G. A., Bullock, A. F., Greenley, S. L., Lind, M. J., Johnson, M. J., & Pearson, M. (2021). Implementation of geriatric assessment in oncology settings: A systematic realist review. Journal of Geriatric Oncology, 12(1), 22-33. https://doi.org/10.1016/j.jgo.2020.07.003

Older adults with cancer are more likely to have worse clinical outcomes than their younger counterparts, and shared decision-making can be difficult, due to both complexity from adverse ageing and under-representation in clinical trials. Geriatric a... Read More about Implementation of geriatric assessment in oncology settings: A systematic realist review.

Physical activity and nutrition interventions for older adults with cancer: a systematic review (2020)
Journal Article
Forbes, C. C., Swan, F., Greenley, S. L., Lind, M., & Johnson, M. J. (2020). Physical activity and nutrition interventions for older adults with cancer: a systematic review. Journal of cancer survivorship : research and practice, 14(5), 689-711. https://doi.org/10.1007/s11764-020-00883-x

Purpose: The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods: We... Read More about Physical activity and nutrition interventions for older adults with cancer: a systematic review.

The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma (2019)
Journal Article
Oguh-Olayinka, L., Agarwal, V., Ranatunge, D., Campbell, A., Laufer, S., Cawkwell, L., & Lind, M. J. (2020). The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma. Pathology and Oncology Research, 26(2), 985-995. https://doi.org/10.1007/s12253-019-00652-x

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenas... Read More about The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma.

LungCARD - Report on worldwide research and clinical practices related to lung cancer (2019)
Journal Article
Jankovic, R., Goncalves, H. J., Cavic, M., Clemente, C., Lind, M., Carrasco, A. M., Nadifi, S., Khyatti, M., Adebambo, T., & Egamberdiev, D. (2019). LungCARD - Report on worldwide research and clinical practices related to lung cancer. Journal of BUON, 24(1), 11-19

© 2019 Zerbinis Publications. All Rights Reserved. Purpose: The management of advanced lung cancer has evolved tremendously over the past two decades. Increasing understanding of the molecular changes that drive tumor progression has transformed the... Read More about LungCARD - Report on worldwide research and clinical practices related to lung cancer.

Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England (2018)
Journal Article
Tataru, D., Spencer, K., Bates, A., Wieczorek, A., Jack, R. H., Peake, M. D., Lind, M. J., & Lüchtenborg, M. (2018). Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England. Cancer epidemiology, 57, 13-23. https://doi.org/10.1016/j.canep.2018.09.001

© 2018 Objectives: We aimed to determine the geographical variation in the proportion of non-small cell lung cancer (NSCLC) patients undergoing curative treatment and assess the relationship between treatment access rates and survival outcomes. Metho... Read More about Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England.

Lung cancer (2018)
Book Chapter
Grundy, S., Barton, R., Campbell, A., Cowen, M., & Lind, M. (2018). Lung cancer. In S. Hart, & M. Greenstone (Eds.), Foundations of Respiratory Medicine (87-118). Springer. https://doi.org/10.1007/978-3-319-94127-1_6

The accurate diagnosis, staging and management of lung cancer occupies a large part of modern adult respiratory practice. Although smoking is less prevalent, the incidence and mortality of this condition remain high, and earlier detection through scr... Read More about Lung cancer.

CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study (2018)
Journal Article
Jackson, G., Gabe, R., Johnson, M., Date, K., Harman, D., Maraveyas, A., Roy, R., & Lind, M. J. (2019). CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study. Journal of Geriatric Oncology, 10(1), 175-177. https://doi.org/10.1016/j.jgo.2018.07.005

One of the primary risk factors in the development of cancer is older age. The demographic shift to an ageing population has given rise to an increased number of older patients with cancer. The extreme heterogeneity within this population renders app... Read More about CAMERA - complete assessment of elderly patients with cancer: A non-randomised feasibility study.

MicroRNA-31 regulates chemosensitivity in malignant pleural mesothelioma (2017)
Journal Article
Moody, H. L., Lind, M. J., & Maher, S. G. (2017). MicroRNA-31 regulates chemosensitivity in malignant pleural mesothelioma. Molecular Therapy - Nucleic Acids, 8(15 September 2017), 317-329. https://doi.org/10.1016/j.omtn.2017.07.001

Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis, and most patients initially are or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9p21.3, whi... Read More about MicroRNA-31 regulates chemosensitivity in malignant pleural mesothelioma.

Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial (2016)
Journal Article
Szlosarek, P. W., Steele, J. P., Nolan, L., Gilligan, D., Taylor, P., Spicer, J., Lind, M., Mitra, S., Shamash, J., Phillips, M. M., Luong, P., Payne, S., Hillman, P., Ellis, S., Szyszko, T., Dancey, G., Butcher, L., Beck, S., Avril, N. E., Thomson, J., …Hackshaw, A. (2017). Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial. JAMA Oncology, 3(1), 58-66. https://doi.org/10.1001/jamaoncol.2016.3049

Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma. The role of the arginine-lowering agent pegylated arginine deiminase (ADI-PEG20)... Read More about Arginine deprivation with pegylated Arginine Deiminase in patients with Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008 (2015)
Journal Article
Tataru, D., Jack, R. H., Lind, M. J., Møller, H., & Lüchtenborg, M. (2015). The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008. Cancer epidemiology, 39(4), 612-616. https://doi.org/10.1016/j.canep.2015.04.008

A large proportion of lung cancer patients in England are diagnosed through an emergency route, which is associated with poorer outcomes. Here, we investigated the association between emergency presentation and the odds of undergoing surgical resecti... Read More about The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008.

Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management (2015)
Journal Article
Jackson, P. C., Wallis, K., Allgar, V., Lind, M. J., & Stanley, P. R. (2015). Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 68(5), 667-672. https://doi.org/10.1016/j.bjps.2014.12.021

© 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Introduction Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumour of the skin. The incidence is rising and it is associated with sun exposure and immunos... Read More about Merkel cell carcinoma in East Yorkshire: A case series and literature review of current management.

Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker (2014)
Journal Article
Garimella, V., Hussain, T., Agarwal, V., Radhakrishna, S., Fox, J. N., Kneeshaw, P. J., Long, E. D., Mahapatra, T. K., McManus, P. L., Lind, M. J., Drew, P. J., & Cawkwell, L. (2014). Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker. International journal of surgery, 12(8), 821-826. https://doi.org/10.1016/j.ijsu.2014.06.009

Primary tamoxifen therapy has been widely used to treat elderly women with ER-positive breast cancer in the past. Aromatase inhibitors may be more beneficial than tamoxifen when used as primary endocrine therapy in elderly patients. We aimed to retro... Read More about Clinical response to primary letrozole therapy in elderly patients with early breast cancer : possible role for p53 as a biomarker.

Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009 (2013)
Journal Article
Lüchtenborg, M., Riaz, S. P., Lim, E., Page, R., Baldwin, D. R., Jakobsen, E., Vedsted, P., Lind, M., Peake, M. D., Mellemgaard, A., Spicer, J., Lang-Lazdunski, L., & Møller, H. (2014). Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009. Thorax, 69(3), 269-273. https://doi.org/10.1136/thoraxjnl-2013-203884

Introduction: Chemotherapy or chemoradiotherapy is the recommended treatment for small cell lung cancer (SCLC), except in stage I disease where clinical guidelines state there may be a role for surgery based on favourable outcomes in case series. Evi... Read More about Survival of patients with small cell lung cancer undergoing lung resection in England, 1998–2009.