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P673: DEPLETION AND RECOVERY OF NORMAL B-CELLS DURING AND AFTER TREATMENT WITH CHEMOIMMUNOTHERAPY, IBRUTINIB OR VENETOCLAX. (2022)
Presentation / Conference Contribution
Rawstron, A., Webster, N., Pitchford, A., Dalal, S., Bloor, A., de Tute, R., Hockaday, A., Jackson, S., Cairns, D., Greatorex, N., Allsup, D., Munir, T., & Hillmen, P. (2022, June). P673: DEPLETION AND RECOVERY OF NORMAL B-CELLS DURING AND AFTER TREATMENT WITH CHEMOIMMUNOTHERAPY, IBRUTINIB OR VENETOCLAX. Presented at European Haematology Association, Vienna

Background: Infectious complications are a major cause of morbidity and mortality in Chronic Lymphocytic Leukaemia (CLL). Therapeutic approaches that deplete CLL cells also affect normal B-cells. Optimal treatment would result in eradication of CLL c... Read More about P673: DEPLETION AND RECOVERY OF NORMAL B-CELLS DURING AND AFTER TREATMENT WITH CHEMOIMMUNOTHERAPY, IBRUTINIB OR VENETOCLAX..

S145: THE COMBINATION OF IBRUTINIB PLUS VENETOCLAX RESULTS IN A HIGH RATE OF MRD NEGATIVITY IN PREVIOUSLY UNTREATED CLL: THE RESULTS OF THE PLANNED INTERIM ANALYSIS OF THE PHASE III NCRI FLAIR TRIAL (2022)
Presentation / Conference Contribution
Hillmen, P., Pitchford, A., Bloor, A., Pettitt, A., Patten, P., Forconi, F., Schuh, A., Fox, C., Elmusharaf, N., Gatto, S., Kennedy, B., Gribben, J., Pemberton, N., Sheehy, O., Preston, G., Howard, D., Hockaday, A., Cairns, D., Jackson, S., Greatorex, N., …Munir, T. (2022, June). S145: THE COMBINATION OF IBRUTINIB PLUS VENETOCLAX RESULTS IN A HIGH RATE OF MRD NEGATIVITY IN PREVIOUSLY UNTREATED CLL: THE RESULTS OF THE PLANNED INTERIM ANALYSIS OF THE PHASE III NCRI FLAIR TRIAL. Presented at European Haematology Association Congress, Vienna

Background: Ibrutinib (I) and venetoclax (V) improve outcome in CLL. I rarely eradicates measurable residual disease (MRD), whereas V (alone or with anti-CD20) can eradicate MRD permitting time limited therapy. Small studies suggest synergy between I... Read More about S145: THE COMBINATION OF IBRUTINIB PLUS VENETOCLAX RESULTS IN A HIGH RATE OF MRD NEGATIVITY IN PREVIOUSLY UNTREATED CLL: THE RESULTS OF THE PLANNED INTERIM ANALYSIS OF THE PHASE III NCRI FLAIR TRIAL.

Novel stressors and trait variation determine X-linked meiotic drive frequency (2025)
Journal Article
Fisher, A. M., White, N., Bonsall, M. B., Price, T. A., & Knell, R. J. (2025). Novel stressors and trait variation determine X-linked meiotic drive frequency. Proceedings of the Royal Society B: Biological Sciences, 292, Article 20250426. https://doi.org/10.1098/rspb.2025.0426

Sex ratio meiotic drive alleles bias their transmission by impairing the viability of non-drive gametes, leading to skewed population sex ratios. Despite theoretical predictions that drive alleles should reach fixation causing population extinction,... Read More about Novel stressors and trait variation determine X-linked meiotic drive frequency.

Gender in preschool (2025)
Journal Article
Kilburn, C. (2025). Gender in preschool. Early Years Educator, 24(17), 1-3. https://doi.org/10.12968/eyed.2025.24.17.1

In the next article in this series, Dr Cathy Kilburn, programme director at the University of Hull, looks at the role children play in reinforcing gender stereotypes and norms among their peers, and what practitioners can do to reduce the impact of s... Read More about Gender in preschool.

Should the altruist stay at home? (2025)
Journal Article
Gonzalez-Arnal, S., & García-Arnaldos, D. (in press). Should the altruist stay at home?. Forum. Supplement to Acta Philosophica,

We consider altruism as a core characteristic of human beings, grounded on an awareness of our interdependence. We address some of the difficulties that an altruist might encounter when promoting the wellbeing of those who are different from himself.... Read More about Should the altruist stay at home?.