Dr Maureen Twiddy's Outputs (5)

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Chetter, I., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer (2025)
Journal Article
McKigney, N., Seligmann, J., Twiddy, M., Bach, S., Mohamed, F., Fearnhead, N., Brown, J., & Harji, D. (2025). A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer. Trials, 26, Article 98. https://doi.org/10.1186/s13063-025-08811-z

The use of interventions such as major liver and lung resection, radiofrequency ablation and transarterial chemoembolization in the management of metastatic colorectal cancer (mCRC) is now relatively commonplace in clinical practice. However, the evi... Read More about A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer.

Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe) (2025)
Journal Article
Raut, S., Hales, A., Twiddy, M., Dixon, L., Ngaage, D., Yates, D., Danjoux, G., & Ingle, L. (2025). Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe). PLoS ONE, 20(3 March), Article e0307341. https://doi.org/10.1371/journal.pone.0307341

Background The concept of “prehabilitation,” or optimising individual physical and mental wellbeing prior to surgery is well established in cancer and orthopaedic populations. However, amongst the cardiac surgery population, the concept is relatively... Read More about Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe).

NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy (2025)
Journal Article
Croft, J., Ainsworth, G., Corrigan, N., Gordon, K., Perry, A., Twiddy, M., Strachan, M., Wadsley, J., Mehanna, H., Sharma, N., Glenister, E., Stocken, D. D., & Balasubramanian, S. P. P. (2025). NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy. BMJ open, 15(1), Article e092422. https://doi.org/10.1136/bmjopen-2024-092422

Introduction Postsurgical hypoparathyroidism (PoSH) is an iatrogenic condition that occurs as a complication of several different procedures with thyroid surgery being the most common. PoSH has significant short- and long-term morbidities. The volume... Read More about NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy.