Dr Maureen Twiddy's Outputs (74)

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Chetter, I., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer (2025)
Journal Article
McKigney, N., Seligmann, J., Twiddy, M., Bach, S., Mohamed, F., Fearnhead, N., Brown, J., & Harji, D. (2025). A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer. Trials, 26, Article 98. https://doi.org/10.1186/s13063-025-08811-z

The use of interventions such as major liver and lung resection, radiofrequency ablation and transarterial chemoembolization in the management of metastatic colorectal cancer (mCRC) is now relatively commonplace in clinical practice. However, the evi... Read More about A Qualitative Study to Understand the Challenges of Conducting Randomised Controlled Trials of Complex Interventions in Metastatic Colorectal Cancer.

Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe) (2025)
Journal Article
Raut, S., Hales, A., Twiddy, M., Dixon, L., Ngaage, D., Yates, D., Danjoux, G., & Ingle, L. (2025). Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe). PLoS ONE, 20(3 March), Article e0307341. https://doi.org/10.1371/journal.pone.0307341

Background The concept of “prehabilitation,” or optimising individual physical and mental wellbeing prior to surgery is well established in cancer and orthopaedic populations. However, amongst the cardiac surgery population, the concept is relatively... Read More about Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe).

NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy (2025)
Journal Article
Croft, J., Ainsworth, G., Corrigan, N., Gordon, K., Perry, A., Twiddy, M., Strachan, M., Wadsley, J., Mehanna, H., Sharma, N., Glenister, E., Stocken, D. D., & Balasubramanian, S. P. P. (2025). NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy. BMJ open, 15(1), Article e092422. https://doi.org/10.1136/bmjopen-2024-092422

Introduction Postsurgical hypoparathyroidism (PoSH) is an iatrogenic condition that occurs as a complication of several different procedures with thyroid surgery being the most common. PoSH has significant short- and long-term morbidities. The volume... Read More about NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy.

Exploring UK clinician perceptions of through-knee amputation compared to above-knee amputation: a mixed methods study (2024)
Journal Article
Gordon, H., Boam, G., Carradice, D., Smith, G. E., & Twiddy, M. (online). Exploring UK clinician perceptions of through-knee amputation compared to above-knee amputation: a mixed methods study. Disability and Rehabilitation, https://doi.org/10.1080/09638288.2024.2441423

Background: Through-knee amputation (TKA) has potential advantages over above-knee amputation (AKA) but is rarely performed in the United Kingdom (UK). This mixed methods study aimed to explore clinicians’ perceptions of TKA compared to AKA. Method:... Read More about Exploring UK clinician perceptions of through-knee amputation compared to above-knee amputation: a mixed methods study.

Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review (2024)
Journal Article
Hermann, L., Arundel, C., Thomas, A., Twiddy, M., & Clark, L. (in press). Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review. Research Methods in Medicine & Health Sciences, https://doi.org/10.1177/26320843241289094

Abstract
Background
Difficulties recruiting to clinical trials are well-documented. Strategies to engage staff from the clinical site where recruitment takes place may be helpful in increasing recruitment rates.
Aim
To systematically review the l... Read More about Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review.

Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study (2024)
Journal Article
Bradshaw, A., Birtwistle, J., Evans, C. J., Sleeman, K. E., Richards, S., Foy, R., Martin, P. M., Carder, P., Allsop, M. J., & Twiddy, M. (2024). Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study. Journal of medical Internet research, 26, Article e50217. https://doi.org/10.2196/50217

BACKGROUND: Palliative care aims to improve the quality of life for people with life-limiting illnesses. Advance care planning conversations that establish a patient's wishes and preferences for care are part of a person-centered approach. Internatio... Read More about Factors Influencing the Implementation of Digital Advance Care Planning: Qualitative Interview Study.

​​Understanding the co-occurrence of alcohol consumption and physical activity in UK adults: A multi-method approach ​ (2024)
Thesis
Akwa, L. G. (2024). ​​Understanding the co-occurrence of alcohol consumption and physical activity in UK adults: A multi-method approach ​. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4910580

Background
Alcohol consumption and physical inactivity are leading risk factors for disease and mortality in adults globally. Despite growing interest in the co-occurrence of health behaviours, there is limited evidence on the co-occurrence of alcoh... Read More about ​​Understanding the co-occurrence of alcohol consumption and physical activity in UK adults: A multi-method approach ​.

"What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey" (2024)
Journal Article
Twiddy, M., & Ramsden, S. (2024). "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey". PLoS ONE, 19(8 AUGUST), Article e0306593. https://doi.org/10.1371/journal.pone.0306593

In England, the Environment Agency (EA) estimates that over 3 million properties in England are at risk of surface water flooding. Heavy and prolonged rainfall that drives surface water flooding is projected to increase in the future due to climate c... Read More about "What influences how well householders living in previously flooded communities feel they are protected or could recover from future flooding?: Results of a survey".

Using PURPOSE T In Clinical Practice: A Realist Evaluation (2024)
Journal Article
Coleman, S., Greenhalgh, J., Schoonhoven, L., Twiddy, M., & Nixon, J. (2024). Using PURPOSE T In Clinical Practice: A Realist Evaluation. Journal of tissue viability, 33(4), 672-680. https://doi.org/10.1016/j.jtv.2024.06.014

Aim
To explain how the clinical and organisational context influenced the way the Pressure Ulcer Risk Primary or Secondary Evaluation Tool (PURPOSE-T) is used by nursing staff to support their clinical judgement and decision making about care planni... Read More about Using PURPOSE T In Clinical Practice: A Realist Evaluation.

A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer (2024)
Thesis
Parker, P. C. A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866373

Background
Although one in eight men will develop some form of prostate cancer (PCa) within their lifetime, not all PCa is of high-risk of progression. In such cases active surveillance (AS) provides an alternative to radical treatment (Hamdy et al.... Read More about A proof of concept study evaluating the role of emerging ultrasound technologies in the active surveillance of localised prostate cancer.

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol (2024)
Journal Article
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Introduction: The aim of this systematic review is to consider the evidence base for home-based high intensity interval training (HIIT) in patients with intermittent claudication (IC). Prior knowledge of the evidence base suggests that there may be l... Read More about Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2024)
Journal Article
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., Pearson, M., & Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation (2024)
Journal Article
Bradshaw, A., Allsop, M. J., Birtwistle, J., Evans, C. J., Relton, S. D., Richards, S. H., Twiddy, M., Foy, R., Millares Martin, P., Yardley, S., Sleeman, K. E., & On Behalf of the OPTIMAL CARE Project. (2024). Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation. Palliative medicine, https://doi.org/10.1177/02692163241280134

Background: Digital advance care planning systems are used internationally to document and share patients’ wishes and preferences to inform care delivery. However, their use is impeded by a limited understanding of factors influencing implementation... Read More about Exploring the contextual assumptions, interventions and outcomes of digital advance care planning systems: A theory of change approach to understand implementation and evaluation.

Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study (2024)
Journal Article
Birtwistle, J., Allsop, M. J., Bradshaw, A., Millares Martin, P., Sleeman, K. E., Twiddy, M., & Evans, C. J. (2024). Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study. Palliative medicine, 38(7), 711-724. https://doi.org/10.1177/02692163241255511

Background: Digital approaches are being explored internationally to support the elicitation, documentation and sharing of advance care planning information. However, the views and experiences of patients and carers are little understood, impeding th... Read More about Views of patients with progressive illness and carers about the role of digital advance care planning systems to record and share information: a qualitative study.

Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: The purpose of this study was to evaluate if the use of micro-ultrasound can detect clinically significant prostate pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having p... Read More about Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom.

Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study (2023)
Journal Article
Drinkwater, J., MacFarlane, A., Twiddy, M., Meads, D., Chadwick, R. H., Donnelly, A., Gleeson, P., Hayward, N., Kelly, M., Mir, R., Prestwich, G., Rathfelder, M., & Foy, R. (2024). Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study. The British journal of general practice : the journal of the Royal College of General Practitioners, 74(745), e552-e559. https://doi.org/10.3399/BJGP.2023.0263

BACKGROUND: Health policy promotes patient participation in decision making about service organisation. In English general practice this happens through contractually required patient participation groups (PPGs). However, there are problems with the... Read More about Patient influence on general practice service improvement decision making: a participatory research mixed-methods intervention study.

Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study (2023)
Journal Article
Akwa, L. G., Smith, L., Twiddy, M., Abt, G., Garnett, C., Oldham, M., Shahab, L., & Herbec, A. (2023). Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study. PLoS ONE, 18(10 October), Article e0287199. https://doi.org/10.1371/journal.pone.0287199

Introduction The COVID-19 pandemic and attendant lockdowns have had a substantial negative effect on alcohol consumption and physical activity globally. Pre-pandemic evidence in the adult population suggests that higher levels of physical activity we... Read More about Associations between physical activity, sedentary behaviour, and alcohol consumption among UK adults: Findings from the Health Behaviours during the COVID-19 pandemic (HEBECO) study.