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Dr Giordano Pula's Outputs (4)

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen (2025)
Journal Article
Leonard, S. V. L., Booth, Z., Naylor-Adamson, L., Bibby, L., Wraith, K. S., Pula, G., Arman, M., & Calaminus, S. D. J. (2025). Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen. Biomolecules, 15(4), Article 501. https://doi.org/10.3390/biom15040501

In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arteria... Read More about Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen.

Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage (2025)
Journal Article
Smallwood, M. J., Alghayth, M. A., Knight, A. R., Tveen-Jensen, K., Pitt, A. R., Spickett, C. M., Llewellyn, D., Pula, G., Wearn, A., Vanhatalo, A., Jones, A. M., Francis, P., Coulthard, E., Kehoe, P. G., & Winyard, P. G. (2025). Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage. Redox Biology, 82, Article 103612. https://doi.org/10.1016/j.redox.2025.103612

Brain inflammation in Alzheimer's disease (AD) involves reactive nitrogen species (RNS) generation. Protein contents of 3-nitrotyrosine, a product of RNS generation, were assessed in frontal lobe brain homogenates from patients with AD, patients with... Read More about Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage.

Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes (2025)
Journal Article
Pula, G., & Greaves, J. (2025). Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes. Frontiers in Bioscience-Landmark, 30(1), Article 26190. https://doi.org/10.31083/FBL26190

Cardiovascular complications claim the lives of up to 70% of patients with diabetes mellitus (DM). The mechanisms increasing cardiovascular risk in DM remain to be fully understood and successfully addressed. Nonetheless, there is increasing evidence... Read More about Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes.

Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties (2024)
Journal Article
Scalia, E., Chirco, A., Calugi, L., Lenci, E., Pagano, P. J., Pula, G., & Trabocchi, A. (2024). Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties. ChemMedChem, 19(19), Article e202400330. https://doi.org/10.1002/cmdc.202400330

The ability of synthetic peptides inhibitors of NOX1 to effectively block the production of ROS by the enzyme was studied with different methodologies. Specifically, taking advantage of our understanding of the active epitope of the regulatory NOX1 s... Read More about Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties.