Matrix Metalloproteinase Activated Multimodal 'Theranostic' Drug Delivery Imaging Agents For Thrombosis

Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation (2023)
Journal Article
Coupland, C. A., Naylor-Adamson, L., Booth, Z., Price, T. W., Gil, H. M., Firth, G., Avery, M., Ahmed, Y., Stasiuk, G. J., & Calaminus, S. D. (2023). Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation. Journal of thrombosis and haemostasis : JTH, 21(9), 2545-2558. https://doi.org/10.1016/j.jtha.2023.05.008

Background: Approximately 17.3% of the global population exhibits an element of zinc (Zn2+) deficiency. One symptom of Zn2+ deficiency is increased bleeding through impaired hemostasis. Platelets are crucial to hemostasis and are inhibited by endothe... Read More about Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation.

Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., Ahmed, Y., Pires, I. M., Stasiuk, G. J., Sturmey, R., Calaminus, S. D., & Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223

Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.