Dr Simon Calaminus S.Calaminus@hull.ac.uk
Senior Lecturer
Matrix Metalloproteinase Activated Multimodal 'Theranostic' Drug Delivery Imaging Agents For Thrombosis
People Involved
Professor David Allsup D.J.Allsup@hull.ac.uk
Professor of Haematology
Dr Jean-Sebastien Bouillard J.Bouillard@hull.ac.uk
Senior Lecturer in Physics and Nanotechnology
Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility (2024)
Journal Article
Naylor-Adamson, L., Price, T. W., Booth, Z., Stasiuk, G. J., & Calaminus, S. D. (2024). Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility. Cells, 13(4), Article 354. https://doi.org/10.3390/cells13040354Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescen... Read More about Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility.
Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets (2023)
Journal Article
Gil, H. M., Booth, Z., Price, T. W., Lee, J., Naylor‐Adamson, L., Avery, M., Muravitskaya, A., Hondow, N., Allsup, D., Schneider, J. E., Naseem, K., Adawi, A. M., Bouillard, J. S. G., Chamberlain, T. W., Calaminus, S. D., & Stasiuk, G. J. (in press). Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets. Small, Article 2304881. https://doi.org/10.1002/smll.202304881InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal-based QDs. Given their intrinsic fluorescent imaging capabilities, these QDs can be potentially relevant for in vivo platelet imaging. The In... Read More about Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets.
Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation (2023)
Journal Article
Coupland, C. A., Naylor-Adamson, L., Booth, Z., Price, T. W., Gil, H. M., Firth, G., Avery, M., Ahmed, Y., Stasiuk, G. J., & Calaminus, S. D. (2023). Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation. Journal of thrombosis and haemostasis : JTH, 21(9), 2545-2558. https://doi.org/10.1016/j.jtha.2023.05.008Background: Approximately 17.3% of the global population exhibits an element of zinc (Zn2+) deficiency. One symptom of Zn2+ deficiency is increased bleeding through impaired hemostasis. Platelets are crucial to hemostasis and are inhibited by endothe... Read More about Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation.
Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging (2022)
Journal Article
Scialla, S., Genicio, N., Brito, B., Florek-Wojciechowska, M., Stasiuk, G. J., Kruk, D., Bañobre-López, M., & Gallo, J. (2022). Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging. ACS Applied Nano Materials, 5(11), 16462–16474. https://doi.org/10.1021/acsanm.2c03537The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions... Read More about Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging.
Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]− (2022)
Journal Article
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., Seymour, A. M., Hermann, P., & Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in aqueous solutions above pH 5, which confers sufficient stability for it to be use... Read More about Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−.
Practical considerations of dissolved oxygen levels for platelet function under hypoxia (2021)
Journal Article
Kusanto, B., Gordon, A., Naylor-Adamson, L., Atkinson, L., Coupland, C., Booth, Z., Ahmed, Y., Pires, I. M., Stasiuk, G. J., Sturmey, R., Calaminus, S. D., & Arman, M. (2021). Practical considerations of dissolved oxygen levels for platelet function under hypoxia. International Journal of Molecular Sciences, 22(24), Article 13223. https://doi.org/10.3390/ijms222413223Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing bloo... Read More about Practical considerations of dissolved oxygen levels for platelet function under hypoxia.
Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies (2021)
Journal Article
Alshamrani, A. F., Santoro, O., Prior, T. J., Alamri, M. A., Stasiuk, G. J., Elsegood, M. R. J., & Redshaw, C. (2021). Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies. Dalton Transactions : an international journal of inorganic chemistry, 50(24), 8302-8306. https://doi.org/10.1039/d1dt01330kInteraction of [Sc(OR)3] (R = iPr or triflate) with p-tert-butylcalix[n]arenes, where n = 4, 6, or 8, affords a number of intriguing structural motifs, which are relatively non-toxic (cytotoxicity evaluated against cell lines HCT116 and HT-29) and a... Read More about Scandium calix[n]arenes (n= 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies.
A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent (2021)
Journal Article
Stasiuk, G. J., Martins, A. F., Botta, M., Prior, T. J., Price, T. W., Kenning, L., Carniato, F., Hoffmann, S. H. L., & Anbu, S. (in press). A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent. Angewandte Chemie, 60(19), 10736-10744. https://doi.org/10.1002/anie.202100885Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application... Read More about A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent.
NIR-quantum dots in biomedical imaging and their future (2021)
Journal Article
Gil, H. M., Price, T. W., Chelani, K., Bouillard, J. S. G., Calaminus, S. D., & Stasiuk, G. J. (2021). NIR-quantum dots in biomedical imaging and their future. iScience, 24(3), Article 102189. https://doi.org/10.1016/j.isci.2021.102189Fluorescence imaging has gathered interest over the recent years for its real-time response and high sensitivity. Developing probes for this modality has proven to be a challenge. Quantum dots (QDs) are colloidal nanoparticles that possess unique opt... Read More about NIR-quantum dots in biomedical imaging and their future.