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A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent

Stasiuk, Graeme J.; Martins, Andre F.; Botta, Mauro; Prior, Timothy J.; Price, Thomas W.; Kenning, Lawrence; Carniato, Fabio; Hoffmann, Sabrina H. L.; Anbu, Sellamuthu


Graeme J. Stasiuk

Andre F. Martins

Mauro Botta

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Dr Tim Prior
Senior Lecturer in Inorganic Chemistry

Thomas W. Price

Lawrence Kenning

Fabio Carniato

Sabrina H. L. Hoffmann

Sellamuthu Anbu


Manganese-based contrast agents (MnCAs) have emerged as suitable alternatives to gadolinium-based contrast agents (GdCAs). However, due to their kinetic lability and laborious synthetic procedures, only a few MnCAs have found clinical MRI application. In this work, we have employed a highly innovative single-pot template synthetic strategy to develop a MnCA, MnL , and studied the most important physicochemical properties in vitro. MnL displays optimized r relaxivities at both medium (20 and 64 MHz) and high magnetic fields (300 and 400 MHz) and an enhanced r =21.1 mM s (20 MHz, 298 K, pH 7.4) upon binding to BSA (K =4.2×10 M ). In vivo studies show that MnL is cleared intact into the bladder through renal excretion and has a prolonged blood half-life compared to the commercial GdCA Magnevist. MnL shows great promise as a novel MRI contrast agent. Me Me b −1 −1 3 −1 Me Me 1 1 a


Stasiuk, G. J., Martins, A. F., Botta, M., Prior, T. J., Price, T. W., Kenning, L., …Anbu, S. (in press). A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent. Angewandte Chemie, 60(19), 10736-10744.

Journal Article Type Article
Acceptance Date Feb 24, 2021
Online Publication Date Apr 1, 2021
Deposit Date Apr 9, 2021
Publicly Available Date Oct 27, 2022
Journal Angewandte Chemie - International Edition
Print ISSN 1433-7851
Electronic ISSN 1521-3773
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 60
Issue 19
Pages 10736-10744
Keywords Bishydrated MnCA; Blood pool agents; In vivo MRI; Mn-based contrast agents; Template synthesis
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Copyright Statement
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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