Stefania Scialla
Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging
Scialla, Stefania; Genicio, Nuria; Brito, Beatriz; Florek-Wojciechowska, Malgorzata; Stasiuk, Graeme J.; Kruk, Danuta; Bañobre-López, Manuel; Gallo, Juan
Authors
Nuria Genicio
Beatriz Brito
Malgorzata Florek-Wojciechowska
Graeme J. Stasiuk
Danuta Kruk
Manuel Bañobre-López
Juan Gallo
Abstract
The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail.
Citation
Scialla, S., Genicio, N., Brito, B., Florek-Wojciechowska, M., Stasiuk, G. J., Kruk, D., Bañobre-López, M., & Gallo, J. (2022). Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging. ACS Applied Nano Materials, 5(11), 16462–16474. https://doi.org/10.1021/acsanm.2c03537
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 27, 2022 |
Online Publication Date | Nov 7, 2022 |
Publication Date | Nov 25, 2022 |
Deposit Date | Dec 13, 2022 |
Publicly Available Date | Jan 3, 2023 |
Journal | ACS Applied Nano Materials |
Print ISSN | 2574-0970 |
Electronic ISSN | 2574-0970 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 5 |
Issue | 11 |
Pages | 16462–16474 |
DOI | https://doi.org/10.1021/acsanm.2c03537 |
Keywords | Magnetic nanocomposites; Magnetic particle interactions; Magnetic resonance imaging; Magnetic hyperthermia; Theranostics |
Public URL | https://hull-repository.worktribe.com/output/4138598 |
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0
Copyright Statement
Creative Commons Licence: Attribution 4.0 International License. See: https://creativecommons.org/licenses/by/4.0/
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