Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging

Scialla, Stefania; Genicio, Nuria; Brito, Beatriz; Florek-Wojciechowska, Malgorzata; Stasiuk, Graeme J.; Kruk, Danuta; Bañobre-López, Manuel; Gallo, Juan

doi:10.1021/acsanm.2c03537

Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging

Scialla, Stefania; Genicio, Nuria; Brito, Beatriz; Florek-Wojciechowska, Malgorzata; Stasiuk, Graeme J.; Kruk, Danuta; Bañobre-López, Manuel; Gallo, Juan

Authors

Stefania Scialla

Nuria Genicio

Beatriz Brito

Malgorzata Florek-Wojciechowska

Graeme J. Stasiuk

Danuta Kruk

Manuel Bañobre-López

Juan Gallo

Abstract

The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail.

Citation

Scialla, S., Genicio, N., Brito, B., Florek-Wojciechowska, M., Stasiuk, G. J., Kruk, D., …Gallo, J. (2022). Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging. ACS Applied Nano Materials, 5(11), 16462–16474. https://doi.org/10.1021/acsanm.2c03537

Journal Article Type	Article
Acceptance Date	Sep 27, 2022
Online Publication Date	Nov 7, 2022
Publication Date	Nov 25, 2022
Deposit Date	Dec 13, 2022
Publicly Available Date	Jan 3, 2023
Journal	ACS Applied Nano Materials
Print ISSN	2574-0970
Electronic ISSN	2574-0970
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	5
Issue	11
Pages	16462–16474
DOI	https://doi.org/10.1021/acsanm.2c03537
Keywords	Magnetic nanocomposites; Magnetic particle interactions; Magnetic resonance imaging; Magnetic hyperthermia; Theranostics
Public URL	https://hull-repository.worktribe.com/output/4138598