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Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties

Alshamrani, Abdullah Fahad A.; Santoro, Orlando; Ounsworth, Samuel; Prior, Timothy J.; Stasiuk, Graeme J.; Redshaw, Carl

Authors

Abdullah Fahad A. Alshamrani

Orlando Santoro

Samuel Ounsworth

Graeme J. Stasiuk

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry



Abstract

The treatment of CuX2 (X = Cl, Br) with an equimolar amount of 2-2ʹ-diphenylglycine (DpgH) in EtOH at reflux afforded, after work up, the complexes [CuCl(Dpg)(EtOH)]2 (1) and [(CuBr2)2(Dpg)2Cu(EtOH)4] (2), respectively. The compounds were obtained microanalytically pure in low to moderate yield (13 and 27%, respectively) and were fully characterised. Synthetic attempts towards Cu-alkoxide species led to the isolation of the heterobimetallic species [(CuCl2)(Dpg)Li(THF)]·THF (3·THF). Finally, complex 4, bearing an imine ligand derived from the decarboxylation of DpgH, was serendipitously obtained from the synthesis of 3. These complexes were found to be inactive in the homo- and co-ring opening polymerization (ROP) of cyclic esters (ε-caprolactone and rac-lactide) and epoxides (propylene oxide and cyclohexene oxide). Compounds 1 and 2 were shown to be non-toxic against cancerous cell lines HCT116 and HT-29.

Citation

Alshamrani, A. F. A., Santoro, O., Ounsworth, S., Prior, T. J., Stasiuk, G. J., & Redshaw, C. (2021). Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties. Polyhedron, 195, https://doi.org/10.1016/j.poly.2020.114977

Journal Article Type Article
Acceptance Date Dec 11, 2020
Online Publication Date Dec 16, 2020
Publication Date Feb 1, 2021
Deposit Date Dec 17, 2020
Publicly Available Date Dec 17, 2021
Journal Polyhedron
Print ISSN 0277-5387
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 195
Article Number 114977
DOI https://doi.org/10.1016/j.poly.2020.114977
Keywords Copper; Diphenylglycine; Crystal structures; Cytotoxicity
Public URL https://hull-repository.worktribe.com/output/3679734
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S0277538720306343?via%3Dihub

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