Skip to main content

Research Repository

Advanced Search

LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy

People Involved

Profile image of Dr David Allsup

Dr David Allsup D.J.Allsup@hull.ac.uk
Senior Lecturer in Haematology and Honorary Consultant

Project Description

Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through delaying treatment, against the potential harm to the fetus through exposure to cancer drugs. Reports suggest that, providing the first trimester is avoided, successful treatment of AL during pregnancy is possible, and considered safe. However, there is currently a lack of standard approach to treatment in this scenario. A new set of British Committee for Standards in Haematology (BCSH) guidelines making recommendations on the diagnosis and management of acute myeloid leukaemia in pregnancy were published in 2015.

This project is to start a UK-wide registry to specifically monitor the management of AL, or high-risk myelodysplasia, in pregnancy, and the associated outcomes for both the mother and neonate, and will also document pregnancies conceived post-treatment. An initial retrospective component will also collect data on cases from the last 5 years. Ultimately the study will be used as a reference from which to derive firm recommendations for the management of these patients, to better inform future patterns of care.

Status Project Complete
Funder(s) Blood Cancer UK
Value £71,112.00
Project Dates Jun 1, 2018 - Feb 28, 2022

You might also like

CLL Research Jan 26, 2015 - Dec 31, 2025
Translational research project utilising prospective sample collection from patients attending the Haematology Clinic, Hull university Teaching Hospital Trust, to facilitate research within the University of Hull.

STATIC: A Randomised Phase III Trial Comparing Continuous with Intermittent Treatment Strategies in Chronic Lymphocytic Leukaemia (CLL) Jan 1, 2021 - Mar 31, 2031
Chronic lymphocytic leukaemia (CLL) is a cancer that affects the blood and bone marrow. It tends to progress slowly, and is incurable. CLL is the most common leukaemia in adults. The first treatment for CLL is chemotherapy. This is usually given for... Read More about STATIC: A Randomised Phase III Trial Comparing Continuous with Intermittent Treatment Strategies in Chronic Lymphocytic Leukaemia (CLL).

Organic Disease masquerading as IBS: an RCT in primary care: The Lincolnshire Poacher Study (Promoting Optimal Assessment to Change Health and Engineer an Economic Revolution Jun 1, 2020 - Apr 30, 2023
Irritable bowel syndrome (IBS) affects up to 1 in 5 people in Britain. IBS can have a huge impact on a sufferer’s daily activities, general wellbeing, and overall health. IBS often carries major financial implications because of time lost from work,... Read More about Organic Disease masquerading as IBS: an RCT in primary care: The Lincolnshire Poacher Study (Promoting Optimal Assessment to Change Health and Engineer an Economic Revolution.