Professor David Allsup D.J.Allsup@hull.ac.uk
Professor of Haematology
LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy
People Involved
Professor Judith Cohen J.Cohen@hull.ac.uk
Director, Hull Health Trials Unit
Project Description
Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through delaying treatment, against the potential harm to the fetus through exposure to cancer drugs. Reports suggest that, providing the first trimester is avoided, successful treatment of AL during pregnancy is possible, and considered safe. However, there is currently a lack of standard approach to treatment in this scenario. A new set of British Committee for Standards in Haematology (BCSH) guidelines making recommendations on the diagnosis and management of acute myeloid leukaemia in pregnancy were published in 2015.
This project is to start a UK-wide registry to specifically monitor the management of AL, or high-risk myelodysplasia, in pregnancy, and the associated outcomes for both the mother and neonate, and will also document pregnancies conceived post-treatment. An initial retrospective component will also collect data on cases from the last 5 years. Ultimately the study will be used as a reference from which to derive firm recommendations for the management of these patients, to better inform future patterns of care.
| Status | Project Complete |
|---|---|
| Value | £71,112.00 |
| Project Dates | Jun 1, 2018 - Feb 28, 2022 |
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