Dr Benjamin Burke
CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging
Project Description
Pleural malignant mesothelioma (PMM) has one of the poorest survival rates of any cancer. We propose a new approach using the latest theranostic technologies that are driving the clinical radiopharmaceutical market and exploiting a new biological target for PET-CT imaging and treatment of PMM.
We will use technology invented and owned by the University of Hull that can be image or treat mesothelioma by simultaneously targeting two chemokine receptors (CXCR4 and CXCR7) that are overexpressed in the disease.
A two-stage process is useed:
(1) The patient is imaged by PET/CT using the imaging drug
(2) If the patient shows the receptor overexpression typical of PMM in the imaging scan then they can be treated with the therapeutic version of the drug.
The aim is to demonstrate radiolabelling and produce an in vivo animal imaging data set to support an application to MRC DPFS for a first-in-human Phase 1 clinical trial.
| Status | Project Complete |
|---|---|
| Value | £63,995.00 |
| Project Dates | Jul 1, 2020 - Jun 30, 2022 |
| Partner Organisations | No Partners |
You might also like
Translational Research in the Molecular Imaging Research Centre Aug 1, 2016 - Jul 31, 2018
New technology to improve capability for clinical radiopharmaceutical production Jan 1, 2019 - Feb 28, 2022
Medical imaging techniques rely on radioactive atoms that don't last for a long time and so methods need to be developed to handle them on hospital sites or close by. Essentially this is drug factory near to the patient as the material is decaying al...
Read More about New technology to improve capability for clinical radiopharmaceutical production.
Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017
Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM) Oct 1, 2013 - Sep 30, 2017
With an increasingly aging population, new treatment solutions for diseased, defective, or damaged tissues need to be developed. Although human donor material would be preferable for these purposes, this is often not available and often associated wi...
Read More about Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM).
Medical Imaging Alliance: Siberia and Hull Sep 3, 2018 - Sep 2, 2019
British Council Newton Trust monies for a workshop in Novosibirsk on the topic of medical imaging. Aim is to forge good links with universities there and then apply for larger funds.