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Coronin is a negative regulator of platelet spreading and thrombus formation

People Involved

Project Description

Platelets are a group of blood cells that become sticky and clump together to form Need guidance? blood clots, ensuring that we stop bleeding after injury. However, in some people platelets also form blood clots inside the blood vessels, which may lead to heart attacks and strokes. To help platelets become sticky and clump together they have to change their shape. Special proteins inside the platelet act as a scaffold and drive changes in shape. We have seen that platelets where a scaffold protein called coronin is missing can change shape more easily. We think that coronin stops platelets from becoming too sticky and reduce the risk of people having heart attacks. In this project we will investigate how coronin inhibits platelet function. We will use platelets taken from the blood of mice that have been changed so that they do not contain coronin. We will study in detail how these altered platelets form blood clots and how this is different from clots formed by normal platelets.

Status Project Complete
Value £106,915.00
Project Dates Jul 1, 2016 - Jun 30, 2019

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