Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging
CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine
People Involved
Dr Azeem Saleem
Project Description
Molecular imaging in cancer allows specific features of the disease to be characterised. In particular, receptor expression levels can be prognostic and allow targeting of systemic radiotherapies. There are roadblocks in the widespread use of molecular imaging technology. Current tools for transition between imaging and therapies are either inadequate, or too complex/expensive for widespread use.
Chelator technology with bioconjugated radioisotopic-metal complexes has dominated nuclear imaging for four decades. Recently, labelling of bio-molecules with PET isotopes (e.g. 18F) has emerged as an alternative.
Our recent breakthrough has shown a third way. This method involves encapsulating radioisotope-imaging tags within a cage preventing interference with external receptor binding groups. This both simplifies production and allows “like-for-like” isotope switching with molecular consistency. We have shown that these cage constructs are stable under physiological conditions and can potentially be used in humans. We now aim to further develop and optimise this technology for use with a wide range of imaging isotopes and also open up the potential for theranostics.
| Project Acronym | CageTag |
|---|---|
| Status | Project Live |
| Value | £481,520.00 |
| Project Dates | Apr 1, 2022 - Mar 31, 2025 |
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