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HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC)

People Involved

Dr Louis Allott

Project Description

Nuclear medicine is a clinical discipline where the unique properties of ionising radiation are harnessed to diagnose and treat diseases like cancer. Positron Emission Tomography (PET) is a medical scan used in nuclear medicine, where a radioactive molecule known as a radiopharmaceutical (or radiotracer/radioligand) is traced around the body; this can be used to give insight into the biological mechanisms driving the progression of a patient’s disease. This unique feature of PET differs from other scans like X-ray, MRI and CT, which give anatomical information like the structure and shape of tumours in the body. Armed with a greater understanding of a patient’s disease, doctors can not only understand the way the body functions but also personalize and tailor their treatment regimen for maximum effect and fewer side-effects. Radiopharmaceuticals have an incredibly short shelf-life owed to the short radioactive half-life of radioisotopes used in nuclear medicine; therefore, unlike traditional pharmaceuticals which can be manufactured, distributed, and stored for month to years, radiopharmaceuticals are produced on demand, the same day as the patients scan.

Status Project Complete
Value £50,000.00
Project Dates Mar 1, 2022 - Feb 28, 2023


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