Effect of hypoxia on prostacyclin-mediated inhibition of platelet function

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen (2025)
Journal Article
Leonard, S. V. L., Booth, Z., Naylor-Adamson, L., Bibby, L., Wraith, K. S., Pula, G., Arman, M., & Calaminus, S. D. J. (2025). Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen. Biomolecules, 15(4), Article 501. https://doi.org/10.3390/biom15040501

In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arteria... Read More about Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen.

PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation (2024)
Journal Article
Naylor-Adamson, L., Price, T. W., Booth, Z., Leonard, S. V. L., Gallo, J., Tung, L. D., Harvell-Smith, S., Thi Kim Thanh, N., Aslam, Z., Allsup, D., Hondow, N., Chamberlain, T., Schneider, J. E., Naseem, K., Bouillard, J. S. G., Stasiuk, G. J., & Calaminus, S. D. (in press). PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation. Journal of Materials Chemistry B, https://doi.org/10.1039/d4tb01334d

Quantum dots (QDs) are semiconducting inorganic nanocrystals, that have garnered interest in biological and medical spheres due, to their potential benefits in biomedical imaging and drug-delivery systems. Indium phosphide QDs shelled with zinc sulph... Read More about PEGylation of indium phosphide quantum dots prevents quantum dot mediated platelet activation.

Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR (2024)
Journal Article
Leonard, S. V. L., Liddle, C. R., Atherall, C. A., Chapman, E., Watkins, M., Calaminus, S. D. J., & Rotchell, J. M. (2024). Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR. Environment International, 188, Article 108751. https://doi.org/10.1016/j.envint.2024.108751

Microplastics (MPs) are an everyday part of life, and are now ubiquitous in the environment. Crucially, MPs have not just been found within the environment, but also within human bodies, including the blood. We aimed to provide novel information on t... Read More about Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR.