Fully humanized model to study the role of endothelial cells in ageing human lung

Dr Leonid Nikitenko L.Nikitenko@hull.ac.uk
Lecturer in Biomedical Sciences

Differentiating the malignant potential of pancreatic cysts Oct 1, 2017 - Dec 31, 2022
The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis. Earlier detection of pan... Read More about Differentiating the malignant potential of pancreatic cysts.

Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases. Jul 2, 2018 - Aug 28, 2018
Endothelial cells play important roles within the human body. They line blood and lymphatic vessels and regulate the work of cardiovascular and lymphatic systems. The faulty function of endothelial cells often contributes to the development of life-t... Read More about Development of fully humanised animal free models to study the role of endothelial cells in chronic diseases..

Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) that mediates the signalling of three peptides - adrenomedullin (AM), calcitonin gene-related peptide (CGRP; neuropeptide) and intermedin (IMD/AM-2). Animal models rev... Read More about Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells.

The characterisation of G-protein coupled receptor CLR in human endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) mediating the effects of three peptide agonists - adrenomedullin (AM), calcitonin gene-related peptide (CGRP) and intermedin (IMD/AM-2) in ectopic expression studies.... Read More about The characterisation of G-protein coupled receptor CLR in human endothelial cells.

Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease). Nov 1, 2020 - Oct 31, 2021
Chronic diseases associated with fibrosis present a challenge for healthcare; two of them are idiopathic pulmonary fibrosis (IPF) and lymphoedema. IPF is a form of lung disease in which scarring occurs (with no known cause) leading to increased breat... Read More about Development and publication of the booklet for the pulmonary fibrosis (disease with a degree of similarity to coronavirus disease)..