Dr Barbara Guinn B.Guinn@hull.ac.uk
Reader in Biomedical Sciences
Dr Barbara Guinn B.Guinn@hull.ac.uk
Reader in Biomedical Sciences
Dr Chao Huang C.Huang@hull.ac.uk
Reader in Statistics
Endometriosis is a chronic incurable condition that is associated with debilitating pain and subfertility. It affects 190 million women worldwide, takes 8 years to diagnose and costs the UK economy £8.2 billion each year in loss of work (predominantly) and healthcare costs.
There is currently no way of diagnosing endometriosis except through invasive laparoscopy procedures which offer little benefit to patients with stage I/II superficial endometriosis. For patients with stage III/IV deep endometriosis, laparoscopy performed by skilled specialist surgeons can provide an opportunity to remove some lesions but this treatment is associated with significant rates of recurrence (approx 40%) while hormonal treatments are incompatable with fertility and have a side-effect profile that is intolerable to many. This points to the urgent need to rapid, robust and, ideally, non-invasive tests to identify endometriosis early and direct patients to the most appropriate clinical care. Although there is no cure for endometriosis, best practise and timely treatment(s) can reduce the severity of symptoms and significantly improve the quality of life for women living with the condition. We have developed a urine test for endometriosis, EndUriT, that offers an opportunity to prioritise patients onto the correct tertiary care pathway, saving patients and the NHS, time and money.
EndUriT can differentiate women with deep from those with superficial endometriosis or pelvic pain (no endometriosis). We now want to refine the test and determine its absolute sensitivity and specificity. We received an amended ethical approval to collect blood and urine samples from 500 healthy donors and patients and now want to assess (1) fresh versus frozen samples (2) samples stored in preservative (3) impact of phase in the menstrual cycle (4) time of day of urine collection (5) first void versus mid-stream urine in anticipation of commercialising EndUriT with Preventx and using Novosanis's preservative.
EndUriT has the opportunity to address one of the most common illnesses in society today. At least as frequent as diabetes, endometriosis is a prime example of an unmet health need. Endometriosis patients suffer particularly from gender inequality, caused by chronic underfunding in women's health. We are seeking funding to address this.
Status | Project Live |
---|---|
Funder(s) | Medical Research Council |
Value | £54,915.00 |
Project Dates | Jul 1, 2023 - Mar 31, 2025 |
Partner Organisations | Novosanis Preventx Limited |
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Read More about PUMA: Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance. A prospective, mixed methods, before and after study identifying the evidence base for the core components of an effective PEWS and the development of an implementation package for implementation and use in the UK.
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Read More about Endoscopic vein harvesting - Research Support Funding.
Pre-Operative Oncotype DX testing: A decision impact study (PRE-DX study) Jul 1, 2022 - Dec 31, 2024
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Newcastle will be research governance sponsor
Industry funded, investigator led study - to be funded by Exact Sciences
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