α-synuclein is a key novel regulator of platelet function.

α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly (2024)
Journal Article
Sennett, C., Jia, W., Khalil, J. S., Hindle, M. S., Coupland, C., Calaminus, S. D., Langer, J. D., Frost, S., Naseem, K. M., Rivero, F., Ninkina, N., Buchman, V., & Aburima, A. (2024). α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly. Cells, 13(24), Article 2089. https://doi.org/10.3390/cells13242089

Granule secretion is an essential platelet function that contributes not only to haemostasis but also to wound healing, inflammation, and atherosclerosis. Granule secretion from platelets is facilitated, at least in part, by Soluble N-ethylmaleimide-... Read More about α-Synuclein Deletion Impairs Platelet Function: A Role for SNARE Complex Assembly.

Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets (2020)
Journal Article
Aburima, A., Berger, M., Spurgeon, B. E., Webb, B. A., Wraith, K. S., Febbraio, M., Poole, A. W., & Naseem, K. M. (2021). Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets. Blood, 137(5), 678-689. https://doi.org/10.1182/blood.2020005382

Thrombospondin-1 (TSP-1) is released by platelets upon activation and can increase platelet activation, but its role in hemostasis in vivo is unclear. We show that TSP-1 is a critical mediator of hemostasis that promotes platelet activation by modula... Read More about Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.