Outputs (2)

cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738

Essentials
Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction.
We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change.
NO inhibits shape change, RhoA/ROCK signalling a... Read More about cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.