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Outputs (4141)

Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis (2024)
Journal Article
Naylor, M., Doherty, G., Draper, H., Fletcher, D. M., Rigby, A., Adedipe, T., & Guinn, B. A. (2024). Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 25(21), Article 11664. https://doi.org/10.3390/ijms252111664

Ovarian torsion (OT) is a rare gynaecological emergency that requires a prompt diagnosis for optimal patient management. To determine whether there were any biomarkers suitable for the non-invasive detection of OT, two independent reviewers performed... Read More about Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis.

Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review (2024)
Journal Article
Hermann, L., Arundel, C., Thomas, A., Twiddy, M., & Clark, L. (in press). Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review. Research Methods in Medicine & Health Sciences, https://doi.org/10.1177/26320843241289094

Abstract
Background
Difficulties recruiting to clinical trials are well-documented. Strategies to engage staff from the clinical site where recruitment takes place may be helpful in increasing recruitment rates.
Aim
To systematically review the l... Read More about Interventions to improve clinical trial recruitment with a focus on clinical staff from the recruiting site: a systematic review.

Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia (2024)
Journal Article
Greiner, J., Mohamed, E., Fletcher, D. M., Schuler, P. J., Schrezenmeier, H., Götz, M., & Guinn, B. A. (2024). Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia. Cancers, 16(20), Article 3443. https://doi.org/10.3390/cancers16203443

Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common genetic abnorm... Read More about Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia.

Disease progression in chronic heart failure is linear: Insights from multistate modelling (2024)
Journal Article
Kazmi, S., Kambhampati, C., Rigby, A. S., Cleland, J. G. F., Kazmi, K. S., Cuthbert, J., Pellicori, P., & Clark, A. L. (online). Disease progression in chronic heart failure is linear: Insights from multistate modelling. European journal of heart failure, https://doi.org/10.1002/ejhf.3400

Aims: Understanding the pattern of disease progression in chronic heart failure (HF) may inform patient care and healthcare system design. We used a four-state Markov model to describe the disease trajectory of patients with HF. Methods and results:... Read More about Disease progression in chronic heart failure is linear: Insights from multistate modelling.

Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis (2024)
Journal Article
Chan, A., Jamieson, C., Draper, H., O'Callaghan, S., & Guinn, B. A. (online). Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis. BMJ Evidence-Based Medicine, https://doi.org/10.1136/bmjebm-2023-112719

Objectives: To examine disparities in attendance rates at cancer screening services between transgender and gender-diverse (TGD) people in comparison with their cisgender (CG) counterparts, and to determine whether these differences were based on the... Read More about Cancer screening attendance rates in transgender and gender-diverse patients: a systematic review and meta-analysis.

Can a human right to good mental health be justified? (2024)
Journal Article
Bielby, P. (2024). Can a human right to good mental health be justified?. Bioethics, 38(8), 733-740. https://doi.org/10.1111/bioe.13329

Can a human right to good mental health be justified? This is an under-explored question: until recently, rights in relation to mental health have been framed and debated primarily in terms of their relevance to psychosocial disability and mental ill... Read More about Can a human right to good mental health be justified?.

Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer? (2024)
Journal Article
Mohamed, E., Fletcher, D., Hart, S., & Guinn, B.-A. (2024). Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?. Onco, 4(2), 87-100. https://doi.org/10.3390/onco4020008

Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors and their discovery rate has been increasing due to enhanced performance of chest CT scans but more than 90% are non-malignant causi... Read More about Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?.

ViPER - Introducing a service to deliver restorative supervision for nursing students, to improve retention and raise the quality of student experiences. (2024)
Presentation / Conference Contribution
Jennison, L., Walker, J., Credland, N., Dixon, P., & Dunn, R. (2024, April). ViPER - Introducing a service to deliver restorative supervision for nursing students, to improve retention and raise the quality of student experiences. Paper presented at RCN Education Forum National Conference and Exhibition 2024: Future Insights: Enabling professional practice in health and social care nursing education, York

Abstract ID 239:
Introduction:
Restorative Supervision (RS) is increasingly being delivered to post qualified healthcare staff, via the growth of the PNA role (NHS England,2023). The benefits of delivering this to pre-registration students in educa... Read More about ViPER - Introducing a service to deliver restorative supervision for nursing students, to improve retention and raise the quality of student experiences..

Help-seeking as relationship-saving: opposing perspectives within the intimate relationship when fathers suffer from postnatal depression (2024)
Presentation / Conference Contribution
Davenport, C. (2024, March). Help-seeking as relationship-saving: opposing perspectives within the intimate relationship when fathers suffer from postnatal depression. Paper presented at Journeys of Masculinity: Bodies, Identities, Wellbeing and the Life Course, University of Surrey [online]

Opening slide:
Current guidance recommends that professionals screen and support mothers during the antenatal and postnatal periods for their mental health.
Despite recommendations that father mental health is assessed, this is not currently routin... Read More about Help-seeking as relationship-saving: opposing perspectives within the intimate relationship when fathers suffer from postnatal depression.

Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants (2024)
Journal Article
Rotchell, J. M., Austin, C., Chapman, E., Atherall, C. A., Liddle, C. R., Dunstan, T. S., Blackburn, B., Mead, A., Filart, K., Beeby, E., Cunningham, K., Allen, J., Draper, H., & Guinn, B.-A. (2024). Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants. Ecotoxicology and environmental safety, 274, Article 116208. https://doi.org/10.1016/j.ecoenv.2024.116208

Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv... Read More about Microplastics in human urine: Characterisation using μFTIR and sampling challenges using healthy donors and endometriosis participants.

Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

Attentional bias in psoriasis: The role of processing time and emotional valence (2023)
Journal Article
Etty, S., George, D. N., van Laarhoven, A., Kleyn, C. E., Walton, S., & Holle, H. (online). Attentional bias in psoriasis: The role of processing time and emotional valence. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12712

Purpose: The present study explored whether people with psoriasis display an attentional bias towards disease-related threat words and whether this bias occurs relatively early during the phase of stimulus disengagement, or during a later maintained... Read More about Attentional bias in psoriasis: The role of processing time and emotional valence.

A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis (2023)
Journal Article
Morris, V., Ghazi, H., Fletcher, D., & Guinn, B. A. (2023). A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 24(11), Article 9667. https://doi.org/10.3390/ijms24119667

Acute myeloid leukaemia (AML) is characterized by impaired myeloid differentiation resulting in an accumulation of immature blasts in the bone marrow and peripheral blood. Although AML can occur at any age, the incidence peaks at age 65. The pathobio... Read More about A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis.

A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells (2023)
Journal Article
Guinn, B. A., Schuler, P. J., Schrezenmeier, H., Hofmann, S., Weiss, J., Bulach, C., Götz, M., & Greiner, J. (2023). A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences, 24(11), Article 9285. https://doi.org/10.3390/ijms24119285

Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp... Read More about A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells.

#118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education (2023)
Presentation / Conference Contribution
Jennison, L., Combe, K., Jennison, L., Pattrick, K., Holden, G., Maile, C., & Morris, T. (2023, April). #118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education. Paper presented at RCN Education Forum National Conference & Exhibition 2023. Ambitions for change: Investing in the health and social care workforce for the future, Birmingham

The NMC Code and educational guidelines recommend nursing students work co-operatively and maintain communication with all fields of practice. Education programs should be designed to deliver
learning that supports students and provides exposure ac... Read More about #118. Co-creation of an educational event to support an integrated field approach, student collaboration and ongoing student growth within health care education.

The Many Challenges of Human Experimental Itch Research (2023)
Book Chapter
Holle, H., & Lloyd, D. M. (2023). The Many Challenges of Human Experimental Itch Research. In N. P. Holmes (Ed.), Somatosensory Research Methods (161-180). Humana Press. https://doi.org/10.1007/978-1-0716-3068-6_8

Itch has long been a neglected sense within somatosensory research, and with good reason: acute itch, although relatively easy to trigger, is notoriously difficult to control experimentally. Its time course and behavior cannot easily be predicted and... Read More about The Many Challenges of Human Experimental Itch Research.

Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women (2023)
Journal Article
Dostan, A., Dobson, C. A., & Vanicek, N. (2023). Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women. PLoS ONE, 18(3), Article e0283333. https://doi.org/10.1371/journal.pone.0283333

Stair ascent is a biomechanically challenging task for older women. Bone health may affect gait stability during stair walking. This study investigated the gait biomechanics associated with stair ascent in a group of postmenopausal women in relation... Read More about Relationship between stair ascent gait speed, bone density and gait characteristics of postmenopausal women.

The effect of survival processing on memory for pictures depends on how memory is tested (2023)
Journal Article
Dewhurst, S. A., Anderson, R. J., O’Connor, R. J., & Dean, G. (in press). The effect of survival processing on memory for pictures depends on how memory is tested. Memory, https://doi.org/10.1080/09658211.2023.2171436

Two experiments investigated the effects of survival processing on memory for pictures of objects. In experiment 1, participants were presented with 32 pictures of common objects and rated them for their relevance to a survival scenario, a moving hom... Read More about The effect of survival processing on memory for pictures depends on how memory is tested.