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Outputs (4156)

Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients (2022)
Journal Article
Ettelaie, C., Benelhaj, N., Featherby, S., Haque, F., Johnson, M., Cooke, J., & Maraveyas, A. (2022). Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients. Journal of Biotechnology and Biomedicine, 5(2), 78-93. https://doi.org/10.26502/jbb.2642-280050

Predicting which cancer patients are at risk of thrombosis remains a key challenge to effective thromboprophylaxis. This study was based on the hypothesis that the rapid release of TF-containing MV occurs in cancer cells that possess high levels of T... Read More about Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients.

microRNA expression in acute myeloid leukaemia: New targets for therapy? (2022)
Journal Article
Fletcher, D., Brown, E., Javadala, J., Uysal-Onganer, P., & Guinn, B. (2022). microRNA expression in acute myeloid leukaemia: New targets for therapy?. eJHaem, 3(3), 596-608. https://doi.org/10.1002/jha2.441

Recent studies have shown that short non-coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in a variety o... Read More about microRNA expression in acute myeloid leukaemia: New targets for therapy?.

Economic evaluation of CPD activities for healthcare professionals: A scoping review (2022)
Journal Article
Orlik, W., Aleo, G., Kearns, T., Briody, J., Wray, J., Mahon, P., Gazić, M., Radoš, N., García Vivar, C., Lillo Crespo, M., & Fitzgerald, C. (2022). Economic evaluation of CPD activities for healthcare professionals: A scoping review. Medical Education, https://doi.org/10.1111/medu.14813

Context: Continuing professional development (CPD) activities for healthcare professionals are central to the optimisation of patient safety and person-centred care. Although there is some evidence on the economics of healthcare professionals trainin... Read More about Economic evaluation of CPD activities for healthcare professionals: A scoping review.

Detection of microplastics in human lung tissue using μFTIR spectroscopy (2022)
Journal Article
Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. Science of the Total Environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MP... Read More about Detection of microplastics in human lung tissue using μFTIR spectroscopy.

Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage (2022)
Journal Article
Ochieng, B. M., Kaseje, M., Kaseje, D. C. O., Oria, K., & Magadi, M. (2022). Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage. BMC health services research, 22(1), Article 226. https://doi.org/10.1186/s12913-022-07632-z

Background: The strategic aim of universal health coverage (UHC) is to ensure that everyone can use health services they need without risk of financial hardship. Linda Mama (Taking care of the mother) initiative focuses on the most vulnerable women,... Read More about Perspectives of stakeholders of the free maternity services for mothers in western Kenya: lessons for universal health coverage.

Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease (2022)
Journal Article
Bolanle, I. O., & Palmer, T. M. (2022). Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease. Cells, 11(4), Article 705. https://doi.org/10.3390/cells11040705

Unresolved hyperglycaemia, a hallmark of type 2 diabetes mellitus (T2DM), is a well characterised manifestation of altered fuel homeostasis and our understanding of its role in the pathologic activation of the inflammatory system continues to grow. M... Read More about Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease.

Defining priorities in vascular access research (2022)
Journal Article
De Siqueira, J., Fielding, C., Pettigrew, G., Robson, M., Rogers, S., Steiner, K., Withers, W., Long, J., Gronlund, T., Chetter, I., & Smith, G. (2022). Defining priorities in vascular access research. Journal of Vascular Societies Great Britain and Ireland, 1(2), 30-33. https://doi.org/10.54522/jvsgbi.2022.013

Introduction: There is increasing need for renal replacement therapy associated with the aging population and dramatic increases in diabetes prevalence. Despite an increasing clinical vascular access workload, there are significant unanswered researc... Read More about Defining priorities in vascular access research.

Research priorities for aortic diseases: results of the James Lind Alliance/Vascular Society GBI priority setting exercise (2022)
Journal Article
Lawson, J., Bown, M., Bicknell, C., Long, J., & Gronlund, T. (2022). Research priorities for aortic diseases: results of the James Lind Alliance/Vascular Society GBI priority setting exercise. Journal of Vascular Societies Great Britain and Ireland, 1(2), 34-41. https://doi.org/10.54522/jvsgbi.2022.009

Background: In order to identify research priorities for aortic disease, a partnership between the Vascular Society of Great Britain and Ireland (VSGBI) and the James Lind Alliance (JLA) was established to capture the interests of a wide group of pat... Read More about Research priorities for aortic diseases: results of the James Lind Alliance/Vascular Society GBI priority setting exercise.

Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review (2022)
Journal Article
Butler, H., Saulat, O., & Guinn, B. A. (2022). Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review. Carcinogenesis, 43(3), 183-189. https://doi.org/10.1093/carcin/bgac012

Clear cell ovarian cancer (CCOC) is a rare type of epithelial cancer often resistant to platinum-based chemotherapy. Biomarkers for the diagnosis of CCOC, and targets for immunotherapy, both have the potential to improve outcomes for patients. Our re... Read More about Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review.

The interface between primary care and care homes: General Practitioner experiences of working in care homes for older people (2022)
Journal Article
White, C., & Alton, E. (in press). The interface between primary care and care homes: General Practitioner experiences of working in care homes for older people. Health and Social Care in the Community, https://doi.org/10.1111/hsc.13734

Supporting residents in care homes for older people is an important, though little studied, aspect of the General Practitioner (GP) role. This study explored GPs’ experiences of working to support older people living in care homes, and the challenges... Read More about The interface between primary care and care homes: General Practitioner experiences of working in care homes for older people.

High verbal working memory load impairs gesture-speech integration: Evidence from a dual task paradigm (2021)
Journal Article
Kandana-Arachchige, K. G., Holle, H., Rossignol, M., Loureiro, I. S., & Lefebvre, L. (2021). High verbal working memory load impairs gesture-speech integration: Evidence from a dual task paradigm. Gesture, 20(3), 354-375. https://doi.org/10.1075/gest.20028.kan

While previous studies have shown the importance of visuo-spatial working memory in the processing of co-speech iconic gestures, clear evidence for a potential involvement of the verbal working memory (vWM) is currently lacking. To address this issue... Read More about High verbal working memory load impairs gesture-speech integration: Evidence from a dual task paradigm.

Factors associated with the timing and number of antenatal care visits among unmarried compared to married youth in uganda between 2006 and 2016 (2021)
Journal Article
Agaba, P., Onukwugha, F., Magadi, M., & Misinde, C. (2021). Factors associated with the timing and number of antenatal care visits among unmarried compared to married youth in uganda between 2006 and 2016. Social Sciences, 10(12), Article 474. https://doi.org/10.3390/socsci10120474

Antenatal care is an important determinant of pregnancy and childbirth outcomes. Although the youth disproportionately experience adverse maternal complications and poor pregnancy outcomes, including maternal mortality, timely and frequent use of ant... Read More about Factors associated with the timing and number of antenatal care visits among unmarried compared to married youth in uganda between 2006 and 2016.

Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair (2021)
Journal Article
Wilkinson, H. N., Guinn, B. A., & Hardman, M. J. (2021). Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair. Frontiers in Cell and Developmental Biology, 9, Article 788596. https://doi.org/10.3389/fcell.2021.788596

Endogenous metals are required for all life, orchestrating the action of diverse cellular processes that are crucial for tissue function. The dynamic wound healing response is underpinned by a plethora of such cellular behaviours, occurring in a time... Read More about Combined Metallomics/Transcriptomics Profiling Reveals a Major Role for Metals in Wound Repair.

The effect of bio-banding on the anthropometric, physical fitness and functional movement characteristics of academy soccer players (2021)
Journal Article
MacMaster, C., Portas, M., Parkin, G., Cumming, S., Wilcox, C., & Towlson, C. (2021). The effect of bio-banding on the anthropometric, physical fitness and functional movement characteristics of academy soccer players. PLoS ONE, 16(11), Article e0260136. https://doi.org/10.1371/journal.pone.0260136

The study examined if maturity status bio-banding reduces within-group variance in anthropometric, physical fitness and functional movement characteristics of 319, under-14 and under-15 players from 19 UK professional soccer academies. Bio-banding re... Read More about The effect of bio-banding on the anthropometric, physical fitness and functional movement characteristics of academy soccer players.

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells (2021)
Journal Article
Adeniran, O. I., Mohammad, M. A., Featherby, S., Maraveyas, A., Boa, A. N., & Ettelaie, C. (2021). Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells. Frontiers in Bioscience-Landmark, 26(10), 752-764. https://doi.org/10.52586/4985

Introduction: The restriction of prolyl-protein cis/trans isomerase 1 (Pin1) activity has been shown to prevent the release of tissue factor (TF) leading to the accumulation of the latter protein within the cell. This study tested the ability of nove... Read More about Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells.