Outputs (76)

Influence of case definition on incidence and outcome of acute coronary syndromes (2016)
Journal Article
Torabi, A., Cleland, J. G. F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., …Rigby, A. (2016). Influence of case definition on incidence and outcome of acute coronary syndromes. Open heart, 3(2), e000487. https://doi.org/10.1136/openhrt-2016-000487

© 2016, BMJ Publishing Group. All rights reserved. Objective: Acute coronary syndromes (ACS) are common, but their incidence and outcome might depend greatly on how data are collected. We compared case ascertainment rates for ACS and myocardial infar... Read More about Influence of case definition on incidence and outcome of acute coronary syndromes.

Ethical decision-making regarding infant viability: A discussion (2016)
Journal Article
Kelly, J., & Welch, E. (2018). Ethical decision-making regarding infant viability: A discussion. Nursing Ethics, 25(7), 897-905. https://doi.org/10.1177/0969733016677869

© The Author(s) 2016. Background: There are no universally agreed rules of healthcare ethics. Ethical decisions and standards tend to be linked to professional codes of practice when dealing with complex issues. Objectives: This paper aims to explore... Read More about Ethical decision-making regarding infant viability: A discussion.

Protein kinase C phosphorylates AMP-Activated protein kinase α1 Ser487 (2016)
Journal Article
Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., …Salt, I. P. (2016). Protein kinase C phosphorylates AMP-Activated protein kinase α1 Ser487. Biochemical Journal, 473(24), 4681-4697. https://doi.org/10.1042/BCJ20160211

The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly characterised. Recent studies have identified phosphorylation of the AMPKα1/α2 catalytic subunit... Read More about Protein kinase C phosphorylates AMP-Activated protein kinase α1 Ser487.

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis (2016)
Journal Article
Fraser, S. D., Sadofsky, L. R., Kaye, P. M., & Hart, S. P. (2016). Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. Scientific reports, 6(1), Article ARTN 38689. https://doi.org/10.1038/srep38689

In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes... Read More about Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis.

Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart (2016)
Journal Article
Tarradas, A., Pinsach-Abuin, M., Mackintosh, C., Llorà-Batlle, O., Pérez-Serra, A., Batlle, M., …Pagans, S. (2017). Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart. Journal of Molecular and Cellular Cardiology, 102, 74-82. https://doi.org/10.1016/j.yjmcc.2016.10.013

Aberrant expression of the sodium channel gene (SCN5A) has been proposed to disrupt cardiac action potential and cause human cardiac arrhythmias, but the mechanisms of SCN5A gene regulation and dysregulation still remain largely unexplored. To gain i... Read More about Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart.

Mapping arginine methylation in the human body and cardiac disease (2016)
Journal Article
Onwuli, D. O., Rigau-Roca, L., Cawthorne, C., & Beltran-Alvarez, P. (2017). Mapping arginine methylation in the human body and cardiac disease. Proteomics. Clinical applications, 11(1-2), Article ARTN 1600106. https://doi.org/10.1002/prca.201600106

Purpose Arginine methylation (ArgMe) is one of the most ubiquitous post-translational modifications, and hundreds of proteins undergo ArgMe in e.g. brain. However, the scope of ArgMe in many tissues, including the heart, is currently under explored.... Read More about Mapping arginine methylation in the human body and cardiac disease.

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation (2016)
Journal Article
Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., …Salt, I. P. (2017). Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, 44-56. https://doi.org/10.1016/j.mce.2016.11.010

Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-in... Read More about Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling (2016)
Journal Article
Rutherford, C., Speirs, C., Williams, J. J., Ewart, M. A., Mancini, S. J., Hawley, S. A., …Palmer, T. M. (2016). Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. https://doi.org/10.1126/scisignal.aaf8566

Adenosine 5′-monophosphate–activated protein kinase (AMPK) is a pivotal regulator of metabolism at cellular and organismal levels. AMPK also suppresses inflammation. We found that pharmacological activation of AMPK rapidly inhibited the Janus kinase... Read More about Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid (2016)
Journal Article
Krey, J. F., Krystofiak, E. S., Dumont, R. A., Vijayakumar, S., Choi, D., Rivero, F., …Barr-Gillespie, P. G. (2016). Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. Journal of Cell Biology, 215(4), 467-482. https://doi.org/10.1083/jcb.201606036

With their essential role in inner-ear function, stereocilia of sensory hair cells demonstrate the importance of cellular actin protrusions. Actin packing in stereocilia is mediated by crosslinkers of the plastin, fascin, and espin families. While mi... Read More about Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow (2016)
Journal Article
Dawson, A., Dyer, C., Macfie, J., Davies, J., Karsai, L., Greenman, J., & Jacobsen, M. (2016). A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow. Biomicrofluidics, 10(6), 064101. https://doi.org/10.1063/1.4964813

© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology. Pr... Read More about A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow.