Outputs (1122)

Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen (2025)
Journal Article
Leonard, S. V., Booth, Z., Naylor-Adamson, L., Bibby, L., Wraith, K. S., Pula, G., Arman, M., & Calaminus, S. D. (2025). Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen. Biomolecules, 15(4), Article 501. https://doi.org/10.3390/biom15040501

In the vascular system, pathological conditions that cause hypoxia are associated with increased platelet activity and thrombosis. Using a platelet spreading assay, we show that severe hypoxia (i.e., 1%), venous (i.e., 5%), and, surprisingly, arteria... Read More about Oxygen Concentration Plays a Critical Role in Fibrinogen-Mediated Platelet Activation via Inactivation of αIIbβ3 and Modulation of Fibrinogen.

Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia (2025)
Journal Article
Tantoush, F., Allsup, D., Naylor-Adamson, L., Voncken, F., & Caserta, S. (2025). Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia. Frontiers in immunology, 16, Article 1531059. https://doi.org/10.3389/fimmu.2025.1531059

Chronic lymphocytic leukaemia (CLL) is an uncurable haematological malignancy and is associated with significant infection morbidity. Bruton’s tyrosine-kinase inhibitors (e.g., ibrutinib) have improved disease outcomes, but severe infections and poor... Read More about Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia.

Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage (2025)
Journal Article
Smallwood, M. J., Alghayth, M. A., Knight, A. R., Tveen-Jensen, K., Pitt, A. R., Spickett, C. M., Llewellyn, D., Pula, G., Wearn, A., Vanhatalo, A., Jones, A. M., Francis, P., Coulthard, E., Kehoe, P. G., & Winyard, P. G. (2025). Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage. Redox Biology, 82, Article 103612. https://doi.org/10.1016/j.redox.2025.103612

Brain inflammation in Alzheimer's disease (AD) involves reactive nitrogen species (RNS) generation. Protein contents of 3-nitrotyrosine, a product of RNS generation, were assessed in frontal lobe brain homogenates from patients with AD, patients with... Read More about Hemoglobin in the brain frontal lobe tissue of patients with Alzheimer's disease is susceptible to reactive nitrogen species-mediated oxidative damage.

Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids (2025)
Journal Article
Rondon, A. M., Featherby, S., Gomes, T., Laghmani, E. H., Ettelaie, C., & Versteeg, H. H. (in press). Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids. Journal of Thrombosis and Thrombolysis, https://doi.org/10.1007/s11239-025-03076-4

Tissue factor (TF) is the main activator of blood coagulation and is associated with thrombosis and tumor progression. It can be released into the blood circulation incorporated within cancer cell-derived extracellular vesicles (EVs). In this study,... Read More about Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids.

Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events (2025)
Thesis
Papachristofi, V. (2025). Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5038856

The modern environment in which we live is replete with chemicals that have accumulated to levels that have been proposed to impact various aspects of physiology. The impact of a selection of these environmental contaminants on the physiology of earl... Read More about Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events.

The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue (2025)
Thesis
Golebiewski, P. (2025). The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5087881

Thyroid cancer (TC) is the most common endocrine malignancy globally. While surgery and radioactive iodine (RAI) therapy generally yield favourable outcomes, prognosis worsens in RAI-refractory or resistant cases, highlighting the need for alternativ... Read More about The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue.

Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor (2025)
Journal Article
Featherby, S. J., Faulkner, E. C., Maraveyas, A., & Ettelaie, C. (2025). Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor. Cancers, 17(4), Article 644. https://doi.org/10.3390/cancers17040644

Background: Interactions between tissue factor (TF) and β1-integrin induce cell signals, but the molecular mechanisms are not completely understood. The extracellular domain of TF and EGF4-βTD domains of β1-integrin were hypothesised to be the most l... Read More about Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor.

The impact of impact: an invitation to philosophise (2025)
Journal Article
Brauer, R., Björn, I., Burgess, G., Dymitrow, M., Greenman, J., Grzelak-Kostulska, E., Pöllänen, P., & Williams, T. (in press). The impact of impact: an invitation to philosophise. Minerva, https://doi.org/10.1007/s11024-024-09558-8

This position paper argues for the introduction of a philosophy of research impact, as an invitation to think deeply about the implications of the impact agenda. It delves into the transformative influence of prioritising the end-product of the resea... Read More about The impact of impact: an invitation to philosophise.

Development of Multimodal Imaging Agents for Thrombosis (2025)
Thesis
Gil, H. (2025). Development of Multimodal Imaging Agents for Thrombosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5088352

Quantum dots (QDs) are colloidal nanoparticles with unique optical and electronic characteristics attributed to quantum confinement effects, making them ideal for fluorescence imaging of biological systems. This thesis investigates the synthesis and... Read More about Development of Multimodal Imaging Agents for Thrombosis.

Novel urinary biomarkers for the non-invasive detection of endometriosis. (2025)
Thesis
Draper, H. (2025). Novel urinary biomarkers for the non-invasive detection of endometriosis. (Thesis). Hull York Medical School, University of Hull and University of York. https://hull-repository.worktribe.com/output/5178894

Introduction: Endometriosis affects 190 million women worldwide, yet there are no accurate non-invasive diagnostic tests that have been shown able to alleviate the average 8-year diagnostic delay. Phosphoglycerate mutase 1 (PGAM1) has been identified... Read More about Novel urinary biomarkers for the non-invasive detection of endometriosis..