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Outputs (1035)

Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids (2025)
Journal Article
Rondon, A. M., Featherby, S., Gomes, T., Laghmani, E. H., Ettelaie, C., & Versteeg, H. H. (in press). Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids. Journal of Thrombosis and Thrombolysis, https://doi.org/10.1007/s11239-025-03076-4

Tissue factor (TF) is the main activator of blood coagulation and is associated with thrombosis and tumor progression. It can be released into the blood circulation incorporated within cancer cell-derived extracellular vesicles (EVs). In this study,... Read More about Comparison of the procoagulant activity between extracellular vesicles obtained from cellular monolayers and spheroids.

Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events (2025)
Thesis
Papachristofi, V. (2025). Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5038856

The modern environment in which we live is replete with chemicals that have accumulated to levels that have been proposed to impact various aspects of physiology. The impact of a selection of these environmental contaminants on the physiology of earl... Read More about Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events.

The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue (2025)
Thesis
Golebiewski, P. (2025). The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5087881

Thyroid cancer (TC) is the most common endocrine malignancy globally. While surgery and radioactive iodine (RAI) therapy generally yield favourable outcomes, prognosis worsens in RAI-refractory or resistant cases, highlighting the need for alternativ... Read More about The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue.

Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor (2025)
Journal Article
Featherby, S. J., Faulkner, E. C., Maraveyas, A., & Ettelaie, C. (2025). Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor. Cancers, 17(4), Article 644. https://doi.org/10.3390/cancers17040644

Background: Interactions between tissue factor (TF) and β1-integrin induce cell signals, but the molecular mechanisms are not completely understood. The extracellular domain of TF and EGF4-βTD domains of β1-integrin were hypothesised to be the most l... Read More about Identification of the Interacting Domains Between Tissue Factor and β1-Integrin and the Signalling Properties of the Two Fibronectin-like Domains of Tissue Factor.

The impact of impact: an invitation to philosophise (2025)
Journal Article
Brauer, R., Björn, I., Burgess, G., Dymitrow, M., Greenman, J., Grzelak-Kostulska, E., Pöllänen, P., & Williams, T. (in press). The impact of impact: an invitation to philosophise. Minerva, https://doi.org/10.1007/s11024-024-09558-8

This position paper argues for the introduction of a philosophy of research impact, as an invitation to think deeply about the implications of the impact agenda. It delves into the transformative influence of prioritising the end-product of the resea... Read More about The impact of impact: an invitation to philosophise.

Development of Multimodal Imaging Agents for Thrombosis (2025)
Thesis
Gil, H. (2025). Development of Multimodal Imaging Agents for Thrombosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5088352

Quantum dots (QDs) are colloidal nanoparticles with unique optical and electronic characteristics attributed to quantum confinement effects, making them ideal for fluorescence imaging of biological systems. This thesis investigates the synthesis and... Read More about Development of Multimodal Imaging Agents for Thrombosis.

Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors. Cancers, 17(1), Article 119. https://doi.org/10.3390/cancers17010119

Chronic lymphocytic leukemia (CLL) treatment has evolved from traditional chemotherapy to targeted therapies, such as Bruton tyrosine kinase (BTK) and BCL-2 inhibitors with significant improvements in survival rates and a transformation of CLL into a... Read More about Chronic Lymphocytic Leukemia Care and Beyond: Navigating the Needs of Long-Term Survivors.

Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes (2025)
Journal Article
Pula, G., & Greaves, J. (2025). Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes. Frontiers in Bioscience-Landmark, 30(1), Article 26190. https://doi.org/10.31083/FBL26190

Cardiovascular complications claim the lives of up to 70% of patients with diabetes mellitus (DM). The mechanisms increasing cardiovascular risk in DM remain to be fully understood and successfully addressed. Nonetheless, there is increasing evidence... Read More about Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes.

Disposable and sensitive electrochemical magneto-immunosensor for point-of-care HCV diagnostics: Targeting HCVcAg, the active viremia biomarker, in patient samples (2024)
Journal Article
Abo-Zeid, M. N., Walter, C., Kitchman, K., Eastick, K., Corless, L., & Greenman, J. (2025). Disposable and sensitive electrochemical magneto-immunosensor for point-of-care HCV diagnostics: Targeting HCVcAg, the active viremia biomarker, in patient samples. Biosensors & bioelectronics, 272, Article 117104. https://doi.org/10.1016/j.bios.2024.117104

Early detection of hepatitis C virus (HCV) infection is crucial for eliminating this silent killer, especially in resource-limited settings. HCV core antigen (HCVcAg) represents a promising alternative to the current “gold standard” HCV RNA assays as... Read More about Disposable and sensitive electrochemical magneto-immunosensor for point-of-care HCV diagnostics: Targeting HCVcAg, the active viremia biomarker, in patient samples.