Outputs (62)

Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression (2024)
Journal Article
Connolly, D., Madden, L. A., Edwards, V., & Lee, V. (2024). Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression. Aerospace Medicine and Human Performance, 95(9), 667-674. https://doi.org/10.3357/AMHP.6391.2024

INTRODUCTION: Biomarker responses to intensive decompression indicate systemic proinflammatory responses and possible neurological stress. To further investigate responses, 12 additional brain and lung biomarkers were assayed. METHODS: A total of 15... Read More about Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression.

Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis (2024)
Journal Article
Metcalfe, J., Orange, S., Madden, L. A., Marshall, P., & Vince, R. V. (2024). Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 32(9), Article 593. https://doi.org/10.1007/s00520-024-08766-y

Purpose: To systematically review and meta-analyse the efficacy of resistance training on quality of life (QOL), fatigue, physical function, and muscular strength in people diagnosed with cancer undergoing chemotherapy. Methods: Electronic databases... Read More about Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.

Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations (2024)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (online). Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations. Biomaterials science / Royal Society of Chemistry, https://doi.org/10.1039/d4bm00692e

Here we used a 3D human hepatic tumour cell culture model to assess the in vitro efficacy of “active” metformin-loaded nanoparticles (NPs) as anticancer therapeutics. The metformin nanocarrier design was repurposed from previous studies targeting bac... Read More about Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations.

‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity (2024)
Journal Article
Orange, S., Roebuck, J., Marshall, P., Madden, L. A., Vince, R. V., & Bell, B. (online). ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12739

Objectives: Living within a larger body brings unique challenges to exercise participation, which are poorly understood. This qualitative study explored the attitudes towards, and experiences of, exercise participation in adults with class III obesit... Read More about ‘I'm a failure again, I can't do it’: Attitudes towards, and experiences of, exercise participation in adults with class III obesity.

Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products (2024)
Thesis
Doyle, B. Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4587910

Upon entering the body, any given xenobiotic can undergo metabolism which facilitates its excretion from the body. When metabolised, a compound typically has the same effects of the initial drug/nutraceutical, however this is not always the case and... Read More about Novel Synthesis Methods For the Production of Human Circulating Metabolites of Natural Products.

Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress (2023)
Journal Article
Connolly, D., Madden, L. A., Edwards, V., D'Oyly, T., Harridge, S., Smith, T., & Lee, V. (2023). Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress. Aerospace Medicine and Human Performance, 94(10), 738-749. https://doi.org/10.3357/AMHP.6247.2023

INTRODUCTION: Consistent blood biomarkers of hypobaric (altitude) decompression stress remain elusive. Recent laboratory investigation of decompression sickness risk at 25,000 ft (7620 m) enabled evaluation of early pathophysiological responses to ex... Read More about Early Human Pathophysiological Responses to Exertional Hypobaric Decompression Stress.

Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram (2023)
Journal Article
Madden, L. A., Vince, R. V., Edwards, V. C., Lee, V. M., & Connolly, D. M. (2023). Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram. Hemato, 4(4), 301-310. https://doi.org/10.3390/hemato4040024

The blood coagulation response to decompression stress in humans has yet to be fully investigated. Here we utilised calibrated automated thrombogram (CAT) on samples from healthy volunteers exposed to decompression stress to investigate real-time thr... Read More about Coagulation Profiles in Humans Exposed to Exertional Hypobaric Decompression Stress Determined by Calibrated Automated Thrombogram.

Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites (2023)
Journal Article
Doyle, B., Madden, L. A., Pamme, N., & Jones, H. (2023). Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites. RSC advances, 13(40), 27696-27704. https://doi.org/10.1039/d3ra03742h

The study of naturally circulating drug metabolites has been a focus of interest, since these metabolites may have different therapeutic and toxicological effects compared to the parent drug. The synthesis of metabolites outside of the human body is... Read More about Immobilised-enzyme microreactors for the identification and synthesis of conjugated drug metabolites.

Digital Health Solutions for Weight Loss and Obesity: A Narrative Review (2023)
Journal Article
Irvin, L., Madden, L. A., Marshall, P., & Vince, R. V. (2023). Digital Health Solutions for Weight Loss and Obesity: A Narrative Review. Nutrients, 15(8), Article 1858. https://doi.org/10.3390/nu15081858

Personal exercise programmes have long been used and prescribed for weight loss and the improvement of quality of life in obese patients. While individualised programmes are usually the preferred option, they can be more costly and challenging to del... Read More about Digital Health Solutions for Weight Loss and Obesity: A Narrative Review.

Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems (2022)
Thesis
Wang, A. Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4249064

The development of in vitro models for advancing the research of cell biology and cell physiology is of great importance to the fields of biotechnology, cancer study, drug testing, toxicity study. The emerging field includes tissue engineering and re... Read More about Advanced biomedical applications of cell clusteroids based on aqueous twophase Pickering emulsion systems.