Outputs (45)

Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy (2011)
Journal Article
Vince, R. V., Madden, L. A., Alonso, C. M., Savoie, H., Boyle, R. W., Todman, M., Paget, T., & Greenman, J. (2011). Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy. Photochemical & photobiological sciences : an international journal, 10(4), 515-522. https://doi.org/10.1039/c0pp00267d

The increasing prevalence of multi-drug resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), necessitates development of alternative modes of bacterial targeting which are not hindered by antibiotic resistance and minimise... Read More about Identification of methicillin-resistant Staphylococcus aureus-specific peptides for targeted photoantimicrobial chemotherapy.

4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) as components of novel light active materials (2011)
Journal Article
Benstead, M., Mehl, G. H., & Boyle, R. W. (2011). 4,4′-Difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) as components of novel light active materials. Tetrahedron, 67(20), 3573-3601. https://doi.org/10.1016/j.tet.2011.03.028

Applications of BODIPY fluorophores as components of light active materials are reviewed.

Polyacrylamide nanoparticles as a delivery system in photodynamic therapy (2011)
Journal Article
Kuruppuarachchi, M., Lowry, A., Savoie, H., Alonso, C., & Boyle, R. W. (2011). Polyacrylamide nanoparticles as a delivery system in photodynamic therapy. Molecular pharmaceutics, 8(3), 920-931. https://doi.org/10.1021/mp200023y

Nanoparticles can be targeted towards, and accumulate in, tumor tissue by the enhanced permeability and retention effect, if sequestration by the reticuloendothelial system (RES) is avoided. The application of nanoparticles in the field of drug deliv... Read More about Polyacrylamide nanoparticles as a delivery system in photodynamic therapy.

A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels (2011)
Journal Article
Palumbo, A., Hauler, F., Dziunycz, P., Schwager, K., Soltermann, A., Pretto, F., Alonso, C., Hofbauer, G. F., Boyle, R. W., & Neri, D. (2011). A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels. The British Journal of Cancer, 104(7), 1106-1115. https://doi.org/10.1038/bjc.2011.78

Background:The possibility of eradicating cancer by selective destruction of tumour blood vessels may represent an attractive therapeutic avenue, but most pharmaceutical agents investigated so far did not achieve complete cures and are not completely... Read More about A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels.

Mesogenic BODIPYs: An investigation of the correlation between liquid crystalline behaviour and fluorescence intensity (2011)
Journal Article
Benstead, M., Beeby, A., Rosser, G. A., Mehl, G. H., & Boyle, R. W. (2011). Mesogenic BODIPYs: An investigation of the correlation between liquid crystalline behaviour and fluorescence intensity. Photochemical & photobiological sciences : an international journal, 10(6), 992-999. https://doi.org/10.1039/c0pp00388c

A series of mesogenic molecules based on the 4,4¢-di?uoro-3a,4a-diaza-s-indacene (BODIPY) ?uorophore have been synthesised and characterised. Each compound consists of one mesogenic unit, based on a cyanobiphenyl core, and one ?uorophore, of varying... Read More about Mesogenic BODIPYs: An investigation of the correlation between liquid crystalline behaviour and fluorescence intensity.

A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity (2010)
Journal Article
Tuncel, S., Dumoulin, F., Gailer, J., Sooriyaarachchi, M., Atilla, D., Durmuş, M., Bouchu, D., Savoie, H., Boyle, R. W., & Ahsen, V. (2011). A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity. Dalton Transactions : an international journal of inorganic chemistry, 40(16), 4067-4079. https://doi.org/10.1039/c0dt01260b

Three Zn(II) phthalocyanines substituted by hydroxyl-terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water-soluble phthalocyanines as type II-photosensitisers for photodynamic therapy,... Read More about A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity.

Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action (2010)
Journal Article
Smith, K., Malatesti, N., Cauchon, N., Hunting, D., Lecomte, R., van Lier, J. E., Greenman, J., & Boyle, R. W. (2011). Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action. Immunology, 132(2), 256-265. https://doi.org/10.1111/j.1365-2567.2010.03359.x

Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize... Read More about Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action.

Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species (2010)
Journal Article
Josefsen, L. B., Aylott, J. W., Beeby, A., Warburton, P., Boyle, J. P., Peers, C., & Boyle, R. W. (2010). Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species. Photochemical & photobiological sciences : an international journal, 9(6), 801-811. https://doi.org/10.1039/c0pp00004c

Reactive oxygen species (ROS) have for some time been implicated in the onset and progression of medical conditions including cancer, ageing, heart disease and Alzheimer's disease. Recently, it has been postulated that ROS play a much more subtle rol... Read More about Porphyrin-nanosensor conjugates. New tools for the measurement of intracellular response to reactive oxygen species.

Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives (2010)
Journal Article
Jha, S., Silversides, J. D., Boyle, R. W., & Archibald, S. J. (2010). Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives. CrystEngComm RSC, 12(6), 1730-1739. https://doi.org/10.1039/b924683e

Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation... Read More about Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives.

Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies (2010)
Journal Article
Alonso, C. M. A., Palumbo, A., Bullous, A. J., Pretto, F., Neri, D., & Boyle, R. W. (2010). Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies. Bioconjugate chemistry, 21(2), 302-313. https://doi.org/10.1021/bc9003537

Synthesis of three new cationic thiol-reactive maleimide-porphyrin derivatives and their use in site-specific conjugation to monoclonal antibodies is reported. The selective reactivity toward thiols is demonstrated using competition experiments, wher... Read More about Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies.