Outputs (66)

Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene (2012)
Journal Article
Ruiz, P., Orbea, A., Rotchell, J. M., & Cajaraville, M. P. (2012). Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene. Ecotoxicology, 21(3), 820-831. https://doi.org/10.1007/s10646-011-0843-6

Recent spills in European waters have released polycyclic aromatic hydrocarbons, important components of heavy fuel oil, and the hydrocarbon styrene. Heavy fuel oil and styrene are classified as potentially genotoxic and carcinogenic. Here we investi... Read More about Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene.

Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure (2012)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Minier, C., & Rotchell, J. M. (2012). Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure. Environmental science and pollution research, 19(7), 2728-2733. https://doi.org/10.1007/s11356-012-0772-9

Purpose: The aim of this study is to develop a normalization method for real-time PCR data by analyzing the most stably expressed control genes in mussel (Mytilus edulis) reproductive tissue. Methods: To facilitate this, six candidate genes, includin... Read More about Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure.

Molecular toxicology of corals: A review (2011)
Journal Article
Rotchell, J. M., & Ostrander, G. K. (2011). Molecular toxicology of corals: A review. Journal of Toxicology and Environmental Health, Part B: Critical Reviews, 14(8), 571-592. https://doi.org/10.1080/10937404.2011.615112

Coral reefs worldwide have become increasingly affected by a phenomenon known as "coral bleaching," the loss of the symbiotic algae from the host corals. The underlying causes and mechanism(s) of coral bleaching are not well known, although several h... Read More about Molecular toxicology of corals: A review.

Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification (2011)
Journal Article
Hardege, J., Rotchell, J., Terschak, J., & Greenway, G. (2011). Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification. Trends in Analytical Chemistry, 30(8), 1320-1326. https://doi.org/10.1016/j.trac.2011.07.004

Changing ocean-carbonate chemistry caused by oceanic uptake of anthropogenic atmospheric carbon dioxide leads to the formation of carbonic acid, thus lowering the pH of the sea with predictions of a decrease from current levels at 8.15 to 7.82 by the... Read More about Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification.

Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis (2011)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Minier, C., & Rotchell, J. M. (2011). Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis. PLoS ONE, 6(7), e22326. https://doi.org/10.1371/journal.pone.0022326

Background: While it is established that vertebrate-like steroids, particularly estrogens (estradiol, estrone) and androgens (testosterone), are present in various tissues of molluscs, it is still unclear what role these play in reproductive endocrin... Read More about Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis.

A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture (2010)
Journal Article
Gerbron, M., Geraudie, P., Rotchell, J., & Minier, C. (2010). A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture. Environmental Toxicology, 25(5), 510-516. https://doi.org/10.1002/tox.20596

There is growing evidence that many chemicals released in the environment are able to disturb the normal endocrinology of organisms affecting the structure and function of their reproductive system. This has prompted the scientific community to devel... Read More about A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture.

Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis (2010)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Puinean, A. M., Hill, E. M., Minier, C., Osada, M., Fenlon, K., & Rotchell, J. M. (2010). Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis. Environmental pollution, 158(9), 2977-2984. https://doi.org/10.1016/j.envpol.2010.05.025

Mytilus edulis were exposed to 17β-estradiol (E2) and the synthetic estrogens ethinyl estradiol (EE2) and estradiol benzoate (EB) for 10 days. Two exposures were performed to determine their effect on vitellogenin (VTG) and estrogen receptor 2 (ER2)... Read More about Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis.

Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis) (2010)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Hill, E. M., Osada, M., Kishida, M., Itoh, N., Kondo, R., Minier, C., & Rotchell, J. M. (2010). Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis). Aquatic Toxicology, 98(2), 178-187. https://doi.org/10.1016/j.aquatox.2010.02.007

Estrogenic contaminants in the aquatic environment are associated with feminisation of male fish, however their effects on some invertebrate species, such as bivalve molluscs, have yet to be characterised. Gametogenesis represents a critical step in... Read More about Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis).

Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination (2009)
Journal Article
Nogueira, P., Pacheco, M., Lourdes Pereira, M., Mendo, S., & Rotchell, J. M. (2010). Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environmental pollution, 158(5), 1783-1790. https://doi.org/10.1016/j.envpol.2009.11.007

The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from... Read More about Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination.

Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene (2009)
Journal Article
Nogueira, P., Lourenço, J., Rodriguez, E., Pacheco, M., Santos, C., Rotchell, J. M., & Mendo, S. (2009). Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene. Aquatic Toxicology, 94(2), 123-130. https://doi.org/10.1016/j.aquatox.2009.06.007

The molecular responses induced during and after an acute exposure to 7,12-dimethylbenz[a]anthracene (DMBA) were analysed in liver, gill and blood cells of juvenile Anguilla anguilla with the aim of developing molecular biomarkers of environmental PA... Read More about Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene.