Outputs (821)

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., Holmes, E., Le Roux, C. W., Atkin, S. L., & Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

What stops students working well in clinical environments? (2015)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2015, March). What stops students working well in clinical environments?. Paper presented at UK Council for Clinical Communication National Conference, Manchester

Aims
* To discuss the challenges for Undergraduate Medical Students when moving from University Based to Full time clinical placements
* Discuss HYMS’ Year Three Induction Block
* To share ideas regarding how to address these challenges

Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors (2015)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2015). Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors. Oncology Nursing Forum, 42(2), 118-127. https://doi.org/10.1188/15.ONF.42-02AP

Purpose/Objectives: To identify and compare the prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors.

Design: Cross-sectional, descriptive survey.

Setting: Nova Scotia, Canada.

Sample: 741 breast,... Read More about Prevalence and correlates of strength exercise among breast, prostate, and colorectal cancer survivors.

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade (2015)
Journal Article
Magwenzi, S., Woodward, C., Wraith, K. S., Aburima, A., Raslan, Z., Jones, H., McNeil, C., Wheatcroft, S., Yuldasheva, N., Febbriao, M., Kearney, M., & Naseem, K. M. (2015). Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood, 125(17), 2693-2703. https://doi.org/10.1182/blood-2014-05-574491

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis. Here, we describe a mechanism fo... Read More about Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade.

QT peak prolongation predicts cardiac death following stroke (2015)
Journal Article
Wong, K. Y. K., MacWalter, R. S., Wong, S. Y. S., Suich, J., Douglas, D., Fraser, H. W., Ogston, S. A., & Struthers, A. D. (2015). QT peak prolongation predicts cardiac death following stroke. Journal of cardiology and current research, 2(1), Article 00050. https://doi.org/10.15406/jccr.2015.02.00050

Cardiac death has been linked in many populations to prolongation of the QT interval (QTe). However, basic science research suggested that the best estimate of the time point when repolarisation begins is near the T-wave peak. We found QT peak (QTp)... Read More about QT peak prolongation predicts cardiac death following stroke.

Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. (2015)
Journal Article
Dierckx, R., Cleland, J. G., Parsons, S., Putzu, P., Pellicori, P., Dicken, B., Boyalla, V., & Clark, A. L. (2015). Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period. JACC: Heart Failure, 3(3), 224-230. https://doi.org/10.1016/j.jchf.2014.11.003

Objectives: This study sought to characterize patients attending a community heart failure (HF) clinic and identified those who were eligible for optimization of beta-blockers (BB) or ivabradine. Background: Among patients with HF due to left ventric... Read More about Prescribing patterns to optimize heart rate. Analysis of 1,000 consecutive outpatient appointments toasingle heart failure clinic over a 6-month period..

Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence (2015)
Journal Article
Lucock, M., Yates, Z., Martin, C., Choi, J.-H., Beckett, E., Boyd, L., LeGras, K., Ng, X., Skinner, V., Wai, R., Kho, J., Roach, P., & Veysey, M. (2015). Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. Bba Clinical, 3, 107-112. https://doi.org/10.1016/j.bbacli.2014.11.005

Purpose
The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homoc... Read More about Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence.

Metabolic regulation during early embryo development (2015)
Thesis
McKeegan, P. Metabolic regulation during early embryo development. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4216544

The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consu... Read More about Metabolic regulation during early embryo development.

Meridians Under the Skin (2014)
Journal Article
Shaw, V., & Aland, R. C. (2014). Meridians Under the Skin. European Journal of Oriental Medicine, 7(6),

The physical nature of the acupuncture meridian system is currently the subject of enquiry. The original structural descriptions for the meridian system contained in the Huang Di Nei Jing, The Yellow Emperor's Canon of Internal Medicine, are detailed... Read More about Meridians Under the Skin.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., Harrison, C. J., Rand, V., Elstob, C., Bown, N., Rowe, D., Lowe, C., Cuthbert, G., Bennett, S., Crosier, S., Bacon, C. M., Onel, K., Scott, K., Scott, D., Travis, L. B., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.