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Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials (2010)
Journal Article
Shahin, Y., Mazari, F., & Chetter, I. (2011). Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials. International journal of surgery, 9(3), 209-213. https://doi.org/10.1016/j.ijsu.2010.12.006

Background Several studies have reported the clinical effects of long-term treatment with cardioprotective medications in patients with lower limb peripheral arterial disease (PAD) in terms of reducing cardiovascular morbidity and mortality. A numbe... Read More about Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials.

Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand? (2010)
Journal Article
Agarwal, V., Lind, M. J., & Cawkwell, L. (2011). Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?. Cancer Treatment Reviews, 37(7), 533-542. https://doi.org/10.1016/j.ctrv.2010.11.004

The median survival for patients with malignant pleural mesothelioma remains extremely poor and there is a need for the development of more effective treatment modalities. The epidermal growth factor receptor is frequently over-expressed in malignant... Read More about Targeted epidermal growth factor receptor therapy in malignant pleural mesothelioma: where do we stand?.

Cough hypersensitivity syndrome: A distinct clinical entity (2010)
Journal Article
Morice, A. H., Faruqi, S., Wright, C. E., Thompson, R., & Bland, J. M. (2011). Cough hypersensitivity syndrome: A distinct clinical entity. Lung, 189(1), 73-79. https://doi.org/10.1007/s00408-010-9272-1

We postulate that most patients with chronic cough have a single discrete clinical entity: Cough Hypersensitivity Syndrome. We constructed a questionnaire that elicits the major components of the syndrome. Here we describe the validation of this ques... Read More about Cough hypersensitivity syndrome: A distinct clinical entity.

Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance (2010)
Journal Article
Smith, G. E., Samuel, N., Wolstenholme, S., Akomolafe, A. B., & Chetter, I. C. (2010). Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance. Ultrasound, 18(4), 186-190. https://doi.org/10.1258/ult.2010.010035

Inflammatory abdominal aortic aneurysms (IAAAs) account for 3-10% of all abdominal aortic aneurysms and are characterized by a thickened aneurysmal wall, with extensive fibrosis and adhesions. Ultrasound remains the investigation of choice for diagno... Read More about Recognition of inflammatory aneurysms in abdominal aortic aneurysm screening and surveillance.

Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., …Hart, S. P. (2011). Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration, 81(2), 142-149. https://doi.org/10.1159/000321997

Background: Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by IgG complexes may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Objective... Read More about Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis.

TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids (2010)
Journal Article
Sadofsky, L. R., Boa, A. N., Maher, S. A., Birrell, M. A., Belvisi, M. G., & Morice, A. H. (2011). TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacological research : the official journal of the Italian Pharmacological Society, 63(1), 30-36. https://doi.org/10.1016/j.phrs.2010.11.004

The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise mechanism of covalent modification with unsaturated carbonyl-containing compounds is unclear, th... Read More about TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.

Statins and ischaemia reperfusion injury: a molecular biological review (2010)
Journal Article
N.A. Abdul Rahman, M., & C. Chetter, I. (2010). Statins and ischaemia reperfusion injury: a molecular biological review. Current Vascular Pharmacology, 8(6), 831-835. https://doi.org/10.2174/157016110793563780

The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are a class of drug used to lower low-density lipoprotein (LDL) levels. However, in recent years, statins have been shown to possess a pleiotropic effect beyond its choleste... Read More about Statins and ischaemia reperfusion injury: a molecular biological review.

Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome (2010)
Journal Article
Sathyapalan, T., Shepherd, J., Arnett, C., Coady, A., Kilpatrick, E. S., & Atkin, S. L. (2010). Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clinical Chemistry, 56(11), 1696-1700. https://doi.org/10.1373/clinchem.2010.144014

BACKGROUND: It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin re... Read More about Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome.