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Outputs (459)

Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (2019). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 30(4), 530-534. https://doi.org/10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More about Agreement between blood draw techniques for assessing platelet activation by flow cytometry.

Integration of oncology and palliative care: a Lancet Oncology Commission (2018)
Journal Article
Kaasa, S., Loge, J. H., Aapro, M., Albreht, T., Anderson, R., Bruera, E., Brunelli, C., Caraceni, A., Cervantes, A., Currow, D. C., Deliens, L., Fallon, M., Gómez-Batiste, X., Grotmol, K. S., Hannon, B., Haugen, D. F., Higginson, I. J., Hjermstad, M. J., Hui, D., Jordan, K., …Lundeby, T. (2018). Integration of oncology and palliative care: a Lancet Oncology Commission. The lancet oncology, 19(11), e588-e653. https://doi.org/10.1016/S1470-2045%2818%2930415-7

Full integration of oncology and palliative care relies on the specific knowledge and skills of two modes of care: the tumour-directed approach, the main focus of which is on treating the disease; and the host-directed approach, which focuses on the... Read More about Integration of oncology and palliative care: a Lancet Oncology Commission.

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., Morice, A. H., Hart, S. P., & Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More about Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis.

Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care (2018)
Journal Article
Allgar, V. L., Chen, H., Richfield, E., Currow, D., Macleod, U., & Johnson, M. J. (2018). Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care. Journal of pain and symptom management, 56(4), 602-612. https://doi.org/10.1016/j.jpainsymman.2018.07.002

Background. The assessment of patients' needs for care is a critical step in achieving patient-centered cancer care. Tools can be used to assess needs and inform care planning. The Needs Assessment Tool:Progressive DiseaseeCancer (NAT:PD-C) is an Aus... Read More about Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care.

Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study (2018)
Journal Article
Currow, D. C., Smith, J. M., Chansriwong, P., Noble, S. I., Nikolaidou, T., Ferreira, D., Johnson, M. J., & Ekström, M. (2018). Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study. European respiratory journal, 52(3), Article 1800684. https://doi.org/10.1183/13993003.00684-2018

Introduction: To explore trajectories of breathlessness intensity by function and life-limiting illness diagnosis in the last 3 weeks of life in palliative care patients.

Methods: Prospective, consecutive cohort with point-of-care data of patients o... Read More about Missed opportunity? Worsening breathlessness as a harbinger of death: a cohort study.

A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol (2018)
Journal Article
Thomas-Jones, E., Lloyd, A., Roland, D., Sefton, G., Tume, L., Hood, K., Huang, C., Edwards, D., Oliver, A., Skone, R., Lacy, D., Sinha, I., Preston, J., Mason, B., Jacob, N., Trubey, R., Strange, H., Moriarty, Y., Grant, A., Allen, D., & Powell, C. (2018). A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol. BMC Pediatrics, 18(1), Article 244. https://doi.org/10.1186/s12887-018-1210-z

© 2018 The Author(s). Background: In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-faceted so... Read More about A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol.

High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets (2018)
Journal Article
Mukherjee, M., Nwaru, B. I., Soyiri, I., Grant, I., & Sheikh, A. (2018). High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets. NPJ Primary Care Respiratory Medicine, 28, Article 27. https://doi.org/10.1038/s41533-018-0094-6

Studies have shown that a small proportion of patients have particularly high needs and are responsible for disproportionally high disease burden. Estimates suggest that 2–5% of patients are high users of healthcare for their health gain. Such patien... Read More about High health gain patients with asthma: a cross-sectional study analysing national Scottish data sets.

Macrolides, reflux and respiratory disease (2018)
Book Chapter
Crooks, M. G., & Nash, T. (2018). Macrolides, reflux and respiratory disease. In A. H. Morice, & P. W. Dettmar (Eds.), Reflux Aspiration and Lung Disease (303-331). Springer. https://doi.org/10.1007/978-3-319-90525-9_25

Macrolides are a family of compounds that belong to the polyketides class. They are characterised by a large macrocyclic lactone ring that is produced by chain extension of propionates to which one or more sugars (usually cladinose and desosamine) at... Read More about Macrolides, reflux and respiratory disease.

Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils (2018)
Journal Article
Birkin, E., Moore, K. S., Huang, C., Christopher, M., Rees, J. I., Jayaprakasam, V., & Fielding, P. A. (2018). Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils. Medicine, 97(24), Article e11040. https://doi.org/10.1097/md.0000000000011040

To determine the extent of physiological variation of uptake of 18F-flurodeoxyglucose (FDG) within palatine tonsils. To define normal limits for side-to-side variation and characterize factors affecting tonsillar uptake of FDG.

Over a period of 16... Read More about Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils.