From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis

Svezhentseva, Ekaterina V.; Vorotnikov, Yuri A.; Solovieva, Anastasiya O.; Pozmogova, Tatiana N.; Eltsov, Ilia V.; Ivanov, Anton A.; Evtushok, Darya V.; Miroshnichenko, Svetlana M.; Yanshole, Vadim V.; Eling, Charlotte J.; Adawi, Ali M.; Bouillard, Jean Sebastien G.; Kuratieva, Natalia V.; Fufaeva, Maria S.; Shestopalova, Lidiya V.; Mironov, Yuri V.; Efremova, Olga A.; Shestopalov, Michael A.

Abstract

Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.

Citation

Svezhentseva, E. V., Vorotnikov, Y. A., Solovieva, A. O., Pozmogova, T. N., Eltsov, I. V., Ivanov, A. A., Evtushok, D. V., Miroshnichenko, S. M., Yanshole, V. V., Eling, C. J., Adawi, A. M., Bouillard, J. S. G., Kuratieva, N. V., Fufaeva, M. S., Shestopalova, L. V., Mironov, Y. V., Efremova, O. A., & Shestopalov, M. A. (2018). From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis. Chemistry: a European journal, 24(68), 17915-17920. https://doi.org/10.1002/chem.201804663

• Journal Article Type: Article
• Acceptance Date: Sep 17, 2018
• Online Publication Date: Sep 17, 2018
• Publication Date: Dec 5, 2018
• Deposit Date: Sep 18, 2018
• Publicly Available Date: Sep 18, 2019
• Journal: Chemistry - A European Journal
• Print ISSN: 0947-6539
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 68
• Pages: 17915-17920
• DOI: https://doi.org/10.1002/chem.201804663
• Keywords: General Chemistry; Cluster compounds; Molybdenum; Tungsten; Hydrolysis; Cytotoxicity
• Public URL: https://hull-repository.worktribe.com/output/1057044
• Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201804663
• Contract Date: Sep 19, 2018