Ekaterina V. Svezhentseva
From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis
Svezhentseva, Ekaterina V.; Vorotnikov, Yuri A.; Solovieva, Anastasiya O.; Pozmogova, Tatiana N.; Eltsov, Ilia V.; Ivanov, Anton A.; Evtushok, Darya V.; Miroshnichenko, Svetlana M.; Yanshole, Vadim V.; Eling, Charlotte J.; Adawi, Ali M.; Bouillard, Jean Sebastien G.; Kuratieva, Natalia V.; Fufaeva, Maria S.; Shestopalova, Lidiya V.; Mironov, Yuri V.; Efremova, Olga A.; Shestopalov, Michael A.
Authors
Yuri A. Vorotnikov
Anastasiya O. Solovieva
Tatiana N. Pozmogova
Ilia V. Eltsov
Anton A. Ivanov
Darya V. Evtushok
Svetlana M. Miroshnichenko
Vadim V. Yanshole
Charlotte J. Eling
Dr Ali Adawi A.Adawi@hull.ac.uk
Reader in Physics
Dr Jean-Sebastien Bouillard J.Bouillard@hull.ac.uk
Senior Lecturer in Physics
Natalia V. Kuratieva
Maria S. Fufaeva
Lidiya V. Shestopalova
Yuri V. Mironov
Olga A. Efremova
Michael A. Shestopalov
Abstract
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.
Citation
Svezhentseva, E. V., Vorotnikov, Y. A., Solovieva, A. O., Pozmogova, T. N., Eltsov, I. V., Ivanov, A. A., …Shestopalov, M. A. (2018). From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis. Chemistry: a European journal, 24(68), 17915-17920. https://doi.org/10.1002/chem.201804663
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 17, 2018 |
Online Publication Date | Sep 17, 2018 |
Publication Date | Dec 5, 2018 |
Deposit Date | Sep 18, 2018 |
Publicly Available Date | Sep 18, 2019 |
Journal | Chemistry - A European Journal |
Print ISSN | 0947-6539 |
Electronic ISSN | 1521-3765 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 68 |
Pages | 17915-17920 |
DOI | https://doi.org/10.1002/chem.201804663 |
Keywords | General Chemistry; Cluster compounds; Molybdenum; Tungsten; Hydrolysis; Cytotoxicity |
Public URL | https://hull-repository.worktribe.com/output/1057044 |
Publisher URL | https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201804663 |
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©2018 The authors
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