Z Lewis
Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch
Lewis, Z; George, David N; Cowdell, Fiona; Holle, Henning
Authors
Dr David George D.George@hull.ac.uk
Senior Lecturer and Head of Psychology
Fiona Cowdell
Dr Henning Holle H.Holle@hull.ac.uk
Reader in Psychology / Director of Research School of Psychology and Social Work
Abstract
While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-Fibres conveying histaminergic itch.
Citation
Lewis, Z., George, D. N., Cowdell, F., & Holle, H. (2019). Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch. Acta Dermato-Venereologica, 99(2), 188-195. https://doi.org/10.2340/00015555-3077
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 25, 2018 |
Online Publication Date | Oct 25, 2018 |
Publication Date | Feb 1, 2019 |
Deposit Date | Oct 26, 2018 |
Publicly Available Date | Nov 27, 2018 |
Print ISSN | 0001-5555 |
Publisher | Society for Publication of Acta Dermato-Venereologica |
Peer Reviewed | Peer Reviewed |
Volume | 99 |
Issue | 2 |
Pages | 188-195 |
DOI | https://doi.org/10.2340/00015555-3077 |
Keywords | Skin temperature; Histamine; Sensory thresholds; Pruritus |
Public URL | https://hull-repository.worktribe.com/output/1134009 |
Publisher URL | http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3077 |
Contract Date | Oct 26, 2018 |
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc/4.0
Copyright Statement
This is an open access article under the CC BY-NC license
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