Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?
Speirs, Claire; Williams, Jamie J. L.; Riches, Kirsten; Salt, Ian P.; Palmer, Timothy M.
Jamie J. L. Williams
Ian P. Salt
Timothy M. Palmer
Exaggerated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid arthritis and cardiovascular diseases. Mutational activation of JAKs is also responsible for several haematological malignancies, including myeloproliferative neoplasms and acute lymphoblastic leukaemia. Accumulating evidence links adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), an energy sensor and regulator of organismal and cellular metabolism, with the suppression of immune and inflammatory processes. Recent studies have shown that activation of AMPK can limit JAK-STAT-dependent signalling pathways via several mechanisms. These novel findings support AMPK activation as a strategy for management of an array of disorders characterised by hyper-activation of the JAK-STAT pathway. This review discusses the pivotal role of JAK-STAT signalling in a range of disorders and how both established clinically used and novel AMPK activators might be used to treat these conditions.
|Journal Article Type||Review|
|Publication Date||Feb 1, 2018|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Speirs, C., Williams, J. J. L., Riches, K., Salt, I. P., & Palmer, T. M. (2018). Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?. Pharmacological research : the official journal of the Italian Pharmacological Society, 128, 88-100. doi:10.1016/j.phrs.2017.10.001|
|Related Public URLs||http://eprints.gla.ac.uk/149822/|
|Additional Information||This article is maintained by: Elsevier; Article Title: Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?; Journal Title: Pharmacological Research; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.phrs.2017.10.001; Content Type: article; Copyright: © 2018 Elsevier Ltd. All rights reserved.|
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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