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Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

Speirs, Claire; Williams, Jamie J. L.; Riches, Kirsten; Salt, Ian P.; Palmer, Timothy M.

Authors

Claire Speirs

Jamie J. L. Williams

Kirsten Riches

Ian P. Salt

Timothy M. Palmer



Contributors

Tim Palmer
Researcher

Abstract

Exaggerated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid arthritis and cardiovascular diseases. Mutational activation of JAKs is also responsible for several haematological malignancies, including myeloproliferative neoplasms and acute lymphoblastic leukaemia. Accumulating evidence links adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), an energy sensor and regulator of organismal and cellular metabolism, with the suppression of immune and inflammatory processes. Recent studies have shown that activation of AMPK can limit JAK-STAT-dependent signalling pathways via several mechanisms. These novel findings support AMPK activation as a strategy for management of an array of disorders characterised by hyper-activation of the JAK-STAT pathway. This review discusses the pivotal role of JAK-STAT signalling in a range of disorders and how both established clinically used and novel AMPK activators might be used to treat these conditions.

Journal Article Type Review
Publication Date Feb 1, 2018
Journal Pharmacological Research
Print ISSN 1043-6618
Electronic ISSN 1096-1186
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 128
Pages 88-100
APA6 Citation Speirs, C., Williams, J. J. L., Riches, K., Salt, I. P., & Palmer, T. M. (2018). Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?. Pharmacological research : the official journal of the Italian Pharmacological Society, 128, 88-100. doi:10.1016/j.phrs.2017.10.001
DOI https://doi.org/10.1016/j.phrs.2017.10.001
Keywords Pharmacology
Related Public URLs http://eprints.gla.ac.uk/149822/
Additional Information This article is maintained by: Elsevier; Article Title: Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?; Journal Title: Pharmacological Research; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.phrs.2017.10.001; Content Type: article; Copyright: © 2018 Elsevier Ltd. All rights reserved.

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Copyright Statement
© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/



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