Association between platelet distribution width and serum uric acid in Chinese population

Liu, Xiaoxia; Wang, Huiying; Huang, Chao; Meng, Zhaowei; Zhang, Wenjuan; Li, Yongle; Yu, Xuefang; Du, Xin; Liu, Ming; Sun, Jinhong; Zhang, Qing; Gao, Ying; Song, Kun; Wang, Xing; Zhao, Li; Fan, Yaguang

Abstract

© 2019 International Union of Biochemistry and Molecular Biology Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This cross-sectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P < 0.05). This study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males. © 2019 BioFactors, 45(3):326–334, 2019.

Citation

Liu, X., Wang, H., Huang, C., Meng, Z., Zhang, W., Li, Y., Yu, X., Du, X., Liu, M., Sun, J., Zhang, Q., Gao, Y., Song, K., Wang, X., Zhao, L., & Fan, Y. (2019). Association between platelet distribution width and serum uric acid in Chinese population. BioFactors, 45(3), 326-334. https://doi.org/10.1002/biof.1491

• Journal Article Type: Article
• Acceptance Date: Dec 11, 2018
• Online Publication Date: Jan 30, 2019
• Publication Date: May 1, 2019
• Deposit Date: Jul 30, 2019
• Publicly Available Date: Jul 30, 2019
• Journal: BioFactors
• Print ISSN: 0951-6433
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 3
• Pages: 326-334
• DOI: https://doi.org/10.1002/biof.1491
• Keywords: Platelet distribution width (PDW); Hyperuricemia; Uric acid (UA); Platelets (PLT); Gender
• Public URL: https://hull-repository.worktribe.com/output/1207807
• Publisher URL: https://iubmb.onlinelibrary.wiley.com/journal/18728081
• Contract Date: Jul 30, 2019